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Penn State vs Ohio State Week 10 Betting Preview
The Penn State Nittany Lions head to Columbus to face the No. 1 Ohio State Buckeyes on Saturday, November 1 at 12:00 PM ET inside Ohio Stadium. The game airs on FOX and headlines Week 10 of the college football previews Interim coach Terry Smith leads a Penn State team that hasn’t beaten the Buckeyes since 2011. The Nittany Lions are trying to end an eight-game losing streak behind freshman QB Ethan Grunkemeyer, who steps in after Drew Allar’s season-ending injury.
Ohio State remains unbeaten at 7-0 (4-0 Big Ten), with QB Julian Sayin guiding the nation’s most efficient passing offense. He’s completing 80 percent of his throws and has elite targets in Jeremiah Smith and Carnell Tate. The Buckeyes own a 4-0 home record and the nation’s top scoring defense (5.9 PPG).
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Line Movement and Odds
Early action opened Ohio State at –21.0, now sitting –20.5 with steady Buckeye money. The total remains 43.5. The moneyline favors Ohio State (–1705) while Penn State sits +945.
Track real-time line moves and totals on the college football odds page
Matchup Breakdown
Penn State Outlook:
You’re facing the best team in the country, but Penn State’s defense has created pressure and turnovers — 14 sacks (17th nationally) and top-10 rankings in both forced fumbles and interceptions. Running back Kaytron Allen (612 yards, 9 TDs) must carry the offense while Grunkemeyer settles in.
Ohio State Outlook:
The Buckeyes’ passing game is explosive and efficient. Sayin has thrown for 1,958 yards and leads an attack that ranks Top 10 in scoring. On defense, the Buckeyes dominate up front and limit opponents to under 220 yards per game.
Expect trench play to decide momentum — Penn State’s defensive front versus Ohio State’s offensive line protection for Sayin.
Injuries and Conditions
Penn State Nittany Lions
- Drew Allar (QB) – Out
- Kaden Saunders (WR) – Questionable
- Kaleb Artis (DT) – Questionable
- Olaivavega Ioane (OL) – Questionable
- Lamont Payne Jr. (S) – Questionable
Ohio State Buckeyes
- Mason Maggs (QB) – Questionable
- Bryson Rodgers (WR) – Questionable
- Logan George (DL) – Questionable
- Maxence LeBlanc (TE) – Questionable
- Ahmed Tounkara (DL) – Questionable
Weather:
Mild, 58°F with light winds and no precipitation expected. Ideal conditions for a clean passing game.
Best Bets and Prediction
ATS Trends:
- Ohio State is 4-0 ATS in 2025.
- Penn State is 17-8 ATS in its last 25 road games.
Model projection: Ohio State 35, Penn State 10.
Best Bet: Ohio State –20.5 spread.
Secondary Lean: Over 43.5 points.
Review more expert analysis in the college football picks section and compare consensus opinions before locking in your ticket.
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Bet confidently, stay sharp, and enjoy the matchup.
