South Carolina Gamecocks vs Vanderbilt Commodores Picks and Predictions September 13th 2025

Vanderbilt Looks to Prove Breakthrough is Real

Vanderbilt opened 2025 in impressive fashion, and now the Commodores aim to show their 2024 success was no fluke. Last week, Vanderbilt outscored Virginia Tech 34-0 in the second half to turn a 10-point deficit into a commanding 44-20 win on the road.

The Commodores are 2-0 for the fourth straight year and are chasing their first 3-0 start since 2017. With an SEC opener looming, Vanderbilt has a chance to make a major statement against South Carolina. Fans can track all college football teams here

South Carolina Searching for Offensive Rhythm

The Gamecocks enter ranked No. 11 with a 2-0 record, but their offense has yet to click. South Carolina has been outgained in both of its first two games and ranks 118th nationally in total offense. They are averaging just 290.5 yards per game, 3.34 yards per carry, and have only four offensive touchdowns this season.

Coach Shane Beamer pointed to inconsistency as the biggest issue, noting the run game has struggled to find its footing. Bettors can follow the latest college football odds and lines to see how South Carolina is valued in the market.

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Vanderbilt’s Defense Coming Together

The key for Vanderbilt may be its resurgent defense. Against Virginia Tech, the Commodores allowed 227 yards and 20 points in the first half but locked down after halftime, giving up only 21 yards the rest of the way. Linebacker Nick Rinaldi earned co-SEC Defensive Player of the Week honors after posting 2.5 tackles for loss, a sack, and a hurry.

Vanderbilt’s veteran quarterback Diego Pavia adds another layer of intrigue. With 463 rushing yards and six rushing touchdowns through two games, the Commodores’ offense is showing balance. Those evaluating Saturday’s matchup should explore the latest college football picks for expert predictions.

Gamecocks Lean on Defense and Special Teams

While the offense sputters, South Carolina’s defense and special teams have carried the load. Vicari Swain already has three punt-return touchdowns this season, tying the program’s single-season record, while Jaron Willis added a fumble-return score.

Defensively, the Gamecocks opened the year with seven straight quarters without allowing a touchdown. That type of dominance will be critical against Vanderbilt’s versatile attack. For more breakdowns like this, check out the full slate of college football previews

History and Stakes

South Carolina has dominated this series, going 30-4 all-time against Vanderbilt and winning 16 straight since 2008. The Commodores’ lone victory over a ranked team in their last 20 tries was last season’s upset over Alabama, a turning point that sparked their first bowl appearance since 2018.

For those looking to get involved in Saturday’s matchup, premium insights are available through expert betting services and fans can also track the performance of the top handicappers on the leaderboard