St. Louis Cardinals vs New York Yankees Picks and Predictions August 16th 2025

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The New York Yankees are set to play against the St. Louis Cardinals at Busch Stadium. The Yankees hold a record of 65-57, ranking third in the AL East. They recently ended a losing streak with a win, and their last ten games show a balanced 5-5 record.

The Cardinals, with a 61-62 record, are fourth in the NL Central. They are currently on a three-game losing streak. Both teams have performed evenly in their last ten games, each with a 5-5 record. The game will be broadcast on FOX, with weather conditions expected to be very hot with broken clouds.

Yankees vs Cardinals Key Information

  • Sport: Baseball
  • Teams: New York Yankees vs. St. Louis Cardinals
  • Venue: Busch Stadium in St. Louis, MO
  • Date: Saturday, August 16, 2025
  • Betting Odds: Yankees Moneyline -147, Cardinals Moneyline +125, Yankees Runline -1.5 (+117), Cardinals Runline +1.5 (-140), Total Over 8.0 (-105), Total Under 8.0 (-115)

The Yankees Can Win If…

The New York Yankees are coming off a 4-3 win against the St. Louis Cardinals. Luis Gil pitched 5 1/3 innings, allowing just one run. Jazz Chisholm Jr. was a standout, hitting a home run and driving in two runs.

The Yankees have been strong at the plate this season. They lead the league in slugging percentage at .446 and home runs with 191. Their ability to hit for power makes them a threat in any game.

Max Fried will start for the Yankees, bringing a 2.94 ERA and 12-5 record. Fried’s consistency on the mound gives the Yankees a good chance to secure another win. With their strong lineup and pitching, the Yankees are well-positioned to win this game.

The Cardinals Can Win If…

The St. Louis Cardinals are set to play against the New York Yankees, hoping to turn things around after their recent 4-3 loss. In that game, the Cardinals had six hits and three extra-base hits but couldn’t secure the win. Key players like Lars Nootbaar and Masyn Winn contributed with doubles, showing their potential to impact the next game.

The Cardinals have a batting average of .249, ranking 9th in the league. Their ability to hit doubles is a strength, with 208 doubles placing them 5th. This shows they can create scoring opportunities and put pressure on opposing defenses.

Sonny Gray will start on the mound for the Cardinals, with an 11-5 record and a WHIP of 1.15. His experience and ability to control the game can be crucial. With the support of hitters like Willson Contreras and Brendan Donovan, the Cardinals have a strong chance to secure a victory.

The Lean

The Yankees are favored to win against the Cardinals with a moneyline of -147. The Yankees have a strong slugging percentage and lead in home runs, which gives them an edge. My model projects the Yankees to win with a score of 5-3, making them a solid pick to win straight up.

The current total for the game is set at 8.0 runs. Both teams have mid-range ERAs and the Yankees have a high slugging percentage. My model projects a total of 8 runs, aligning with the line. Given the pitching and hitting stats, the under 8.0 at -115 is the recommended pick.

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Yankees vs. Cardinals Preview: Fried’s Reset vs. Gray’s Groove

The Yankees continue a tightly packed American League wild-card chase and arrive in St. Louis looking for a statement from Max Fried after two rocky turns. The Cardinals counter with Sonny Gray, who has dialed in lately and embraces the spotlight. For more context on matchups across today’s slate, browse the full MLB previews.

Where Both Teams Stand

New York has won three of four to strengthen its hold on the third AL wild-card position. St. Louis, meanwhile, has dropped three straight and slipped 3 1/2 games back of the final National League wild-card berth. The intersection of urgency and national-stage visibility makes this a tone-setter for both clubs.

Projected Starters and Key Matchups

Max Fried (12-5, 2.94) opened the year with a 1.92 ERA over his first 17 starts but has battled command pockets across his past seven, allowing 29 runs (24 earned) in 36 innings. The stuff remains lively; the question is execution at the edges.

Sonny Gray (11-5, 4.06) has allowed three runs (two earned) over his last 14 innings, striking out 15 with only two walks in consecutive 3-2 wins. He thrives when the stage is big and the opponent is marquee, and this one checks both boxes. For deeper angles on how to handicap starting-pitcher form and pitch-mix shifts, see the MLB expert betting guide.

Yankees Outlook

Manager Aaron Boone points to command as the lever for Fried’s bounce-back. If the lefty lands his fastball and cutter early, his breaking repertoire can play off the zone and shorten the game for the bullpen. The lineup could also get a lift if Paul Goldschmidt—back at Busch—returns to the starting nine after appearing late on Friday. Before locking in any wagers tied to lineup news, check today’s actionable MLB picks.

Cardinals Outlook

St. Louis needs Gray to carry the tempo and push this into a bullpen game on script. Health remains a subplot, with Willson Contreras and Brendan Donovan questionable after sitting Friday. If the Cardinals’ depth pieces are limited, manufacturing runs against a high-quality lefty becomes even more reliant on situational execution. Track how those statuses evolve and compare market moves inside the day’s MLB previews hub.

X-Factors and What to Watch

• Fried’s first two innings: early strike percentage and glove-side fastball/cutter command will telegraph whether the reset is real.
• Gray vs. right-handed power: can he win at the top of the zone and steal strikes with the slider to keep the ball in the park?
• Run environment at Busch: a single crooked inning could decide it if both starters find their level.

If you prefer tailing or fading specific trends and capper profiles, compare perspectives on the Best Handicappers leaderboard before you commit.

Betting Notes

Lean under early if Fried’s command appears crisp; otherwise, the live market may swing quickly toward St. Louis when Gray gets a lead to protect. For curated selections and graded confidence levels across the board, tap into today’s MLB picks. If you want premium, risk-managed tickets from vetted pros, secure access on Buy Picks.

After the Final Out

Confirm how the pitching duel played out and measure your read against the box score with the latest MLB game results. Then circle back to the previews page to set up tomorrow’s card.

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