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Chicago White Sox vs San Diego Padres September 21st 2025
The San Diego Padres will take on the Chicago White Sox at Rate Field in Chicago. The Padres have a record of 84-71 and are ranked second in their division. They are coming off a win and have gone 5-5 in their last ten games. Michael King will start for the Padres, bringing an ERA of 3.84.
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The White Sox hold a 58-97 record and sit at the bottom of their division. They lost their last game and have a 3-7 record in their last ten games. Sean Burke will start on the mound for the White Sox with an ERA of 4.29. The weather forecast predicts a mild day with light rain and a light breeze. The game is set for Sunday, September 21, 2025, at 2:10 PM and will be broadcast on SDPA.
Padres vs White Sox Key Information
- Sport: Baseball
- Teams: San Diego Padres vs. Chicago White Sox
- Venue: Rate Field in Chicago, IL
- Date: Sunday, September 21, 2025
- Betting Odds:
- Padres Moneyline: -178
- White Sox Moneyline: +150
- Padres Runline: -1.5 (-105)
- White Sox Runline: +1.5 (-115)
- Total Over: 8.0 (-111)
- Total Under: 8.0 (-109)
The Padres Can Win If…
The San Diego Padres secured a 7-3 win over the Chicago White Sox in their last outing. Jackson Merrill delivered a big home run and scored three runs, while Ryan O’Hearn added three hits and three RBIs to fuel the offense.
San Diego holds a .252 team batting average, ranked 6th in the league, and they also rank 11th in doubles with 248. Their pitching has been elite, with a 3.70 ERA that places them 4th overall.
Michael King will start, bringing a 3.84 ERA and 1.17 WHIP. Supported by Manny Machado and Fernando Tatis Jr., the Padres have both the offense and pitching to clinch another win.
Starting Pitchers Comparison
| Pitcher | Team | Record | ERA | WHIP | Strikeouts |
|---|---|---|---|---|---|
| Michael King | Padres | 4-3 | 3.84 | 1.17 | 122 |
| Sean Burke | White Sox | 4-10 | 4.29 | 1.28 | 108 |
The White Sox Can Win If…
The Chicago White Sox are looking to rebound after their 7-3 loss to San Diego. Lenyn Sosa hit a home run, and Miguel Vargas contributed two hits, including a double, to highlight their offensive potential.
Chicago’s 156 home runs rank 18th in MLB, but their power remains a weapon. Sean Burke will take the mound with a 4.29 ERA, aiming to give the White Sox a chance to hang tough.
With Sosa’s 21 homers and Edgar Quero’s .275 batting average, the White Sox have some offensive spark. If their hitters deliver timely power, they can make this game competitive.
The Lean
The Padres enter as -178 favorites, while the White Sox sit at +150. San Diego has a significant pitching edge with a 3.70 ERA compared to Chicago’s 4.26. My model projects a 5-3 Padres win, making them the moneyline recommendation.
The total is set at 8.0 runs. The Padres’ staff holds hitters to a .225 average, suggesting a low-scoring game. My model projects 8 runs, aligning with the line, so the under 8.0 (-109) is the safer play.
Check today’s full MLB picks for more betting insights.
Recent Form and Motivation
The Padres (84-71) are close to clinching their second straight postseason berth, with a magic number of three. Winning here keeps their division and wild-card hopes alive.
Meanwhile, the White Sox (58-97) are looking to avoid their second straight 100-loss season. For players like Michael Tauchman and Lenyn Sosa, these games are about showcasing future value as the team rebuilds.
Key Matchups
- Gavin Sheets has been productive for San Diego with 19 homers and 69 RBIs since joining the team.
- Michael Tauchman made three highlight-reel catches in the last game, proving his defensive value.
- Michael King faces the White Sox for the first time as a starter after four relief appearances with the Yankees.
- Sean Burke struck out eight Padres in his only career start against them in 2024.
Explore every MLB team page to review full rosters and player stats.
Betting Trends
| Trend |
|---|
| Padres are 6-2 in their last 8 road games. |
| White Sox are 1-6 in their last 7 overall. |
| Under has hit in 5 of the Padres’ last 7 games. |
Stay updated with the latest MLB odds before locking in your bets.
Game Preview Recap
The Padres are surging toward the playoffs, while the White Sox are simply playing out their schedule. Michael King will aim to continue San Diego’s winning ways, while Sean Burke tries to spoil their push.
Chicago has struggled with consistency, but their young hitters have shown flashes. Meanwhile, San Diego’s lineup depth and pitching stability are clear advantages. Expect the Padres to control this game with both their bats and their arms.
Read the complete MLB expert betting guide for strategies on similar late-season matchups.
