Ohio State vs Washington Week 5 Odds, Picks & Preview

Washington Huskies vs Ohio State Buckeyes September 27th 2025

In Week 5 of the 2025 regular season, the Ohio State Buckeyes will travel to Seattle to take on the Washington Huskies. This game will be held at Husky Stadium, an outdoor field, on Saturday, September 27, 2025. The game is set to kick off at 3:30 PM and will be broadcast on CBS.

Both teams enter the game with a 3-0 record. Ohio State holds the top spot in both the AP and Coaches Poll rankings. Washington has been strong at home with a 2-0 record. This game marks Ohio State’s first road game of the season, while Washington looks to continue their winning streak at home.

Ohio State vs Washington CFB Key Information

Sport: College Football
Teams: Ohio State Buckeyes vs. Washington Huskies
Venue: Husky Stadium in Seattle, WA
Date: Saturday, September 27, 2025
Betting Odds: Ohio State Moneyline -327, Washington Moneyline +258, Ohio State Spread -8.5 (-111), Washington Spread +8.5 (-110), Total Over 51.5 (-112), Total Under 51.5 (-109)

Ohio State vs Washington Week 5 Betting Preview

The Ohio State Buckeyes travel west to face the Washington Huskies in Seattle. Both teams are 3–0, making this one of the top showdowns of the week.

Ohio State dominated Ohio 37–9 in its last outing, piling up 573 yards of offense while the defense stayed perfect against the run. Washington, fresh off a 59–24 Apple Cup rout of Washington State, rides a 22-game home win streak into its first Big Ten test.

Line Movement and Odds

Ohio State opened as an 8.5-point favorite with the total at 51.5. Current numbers at the college football odds board show the line holding steady, with slight lean toward the over. Sharps see Washington’s offense as a threat to Ohio State’s elite defense.

Matchup Breakdown

Ohio State Buckeyes

QB Julian Sayin has thrown for 779 yards and 8 touchdowns in three starts.
WR Jeremiah Smith and Carnell Tate form a dangerous duo with 534 combined yards and 6 TDs.
RB Bo Jackson brings power with 217 yards in two games.
Defense ranks first nationally in points allowed (5.3 per game) and hasn’t surrendered a rushing TD.

Washington Huskies

QB Demond Williams Jr. is a dual-threat, throwing for 298 yards and rushing for 88 vs Washington State.
RB Jonah Coleman leads the nation with 9 rushing TDs.
WR Denzel Boston adds 249 yards and 3 TDs as a reliable target.
Defense ranks top-10 in sacks and turnovers forced, giving their offense extra possessions.

Key battle
Washington’s explosive ground game vs an Ohio State front that hasn’t allowed a rushing score all year.

Injuries and Conditions

Ohio State Buckeyes

No major injuries entering Week 5.

Washington Huskies

LB Taariq Al-Uqdah out (knee).
CB Tacario Davis questionable (upper body).

Weather in Seattle: clear skies expected, crowd noise will be significant in Husky Stadium.

Best Bets and Prediction

Projected score: Ohio State 34, Washington 20

Best Bet: Ohio State –8.5
Secondary Lean: Over 51.5

Ohio State’s balance and defensive dominance tilt the matchup. Washington can score but will be tested against the most physical defense they’ve seen.

Handicapping Angle

Compare expert college football picks for this clash, and check top performers on the Handicapper Leaderboard. For more strategy, the Bettors Handbook offers insights that can help you find value plays.

Washington Huskies vs Ohio State Buckeyes Picks and Predictions September 27th 2025