Oregon vs Penn State Week 5 Odds, Picks & Preview

Penn State Nittany Lions vs Oregon Ducks September 27th 2025

In Week 5 of the 2025 college football season, the Oregon Ducks will travel to face the Penn State Nittany Lions. The game will take place at Beaver Stadium in University Park, PA. Kickoff is set for Saturday, September 27, 2025, at 7:30 PM and will be broadcast on NBC.

The Ducks come into this game with a 4-0 record, ranked #6 in the AP Poll and #5 in the Coaches Poll. Meanwhile, the Nittany Lions hold a 3-0 record, ranked #3 in the AP Poll and #2 in the Coaches Poll. Both teams are part of the Big Ten Conference, adding an extra layer of competition to this matchup.

Oregon vs Penn State CFB Key Information

Sport: College Football
Teams: Oregon Ducks vs. Penn State Nittany Lions
Venue: Beaver Stadium in University Park, PA
Date: Saturday, September 27, 2025
Betting Odds: Oregon Moneyline +138, Penn State Moneyline -164, Oregon Spread +3.5 (-115), Penn State Spread -3.5 (-105), Total Over 52.5 (-109), Total Under 52.5 (-111)

Oregon vs Penn State Week 5 Betting Preview

The Oregon Ducks will visit the Penn State Nittany Lions Saturday night in Beaver Stadium for the Big Ten’s marquee White Out game. Oregon enters 4–0 with dominant wins; Penn State (3–0) is looking for redemption after losing to Oregon in last year’s conference title game.

Oregon has outscored its first four opponents 203–37 and ranks among national leaders in scoring offense. Meanwhile, Penn State boasts one of the stingiest defenses in the country. (CBSSports live recap)

Line Movement and Odds

The line opened with Penn State –3.5, which remains stable. The total (O/U) is set at 52.5.
Public money leans Penn State; sharp bets have shown interest in the Ducks’ moneyline.
The spread and total can be monitored on our college football odds page.

Matchup Breakdown

Oregon Ducks

QB Dante Moore has been efficient through four games with 962 passing yards and 11 touchdowns.
The run game is strong, ranked among top 10 nationally in rushing yards.
Defense has allowed just 37 total points — solid in both rush and pass coverage.
Oregon holds opponents to ~94 passing yards per game. (

Penn State Nittany Lions

Penn State ranks third in scoring defense, allowing ~5.7 points per game.
QB Drew Allar leads a balanced offense with RBs Nicholas Singleton and Kaytron Allen.
Last year, Allar threw for 226 yards and 3 touchdowns against Oregon, and the Lions rushed for nearly 300 yards.

Key battle
Oregon’s ability to sustain drives against Penn State’s pressure. If Moore executes under duress and the Ducks mix run and pass effectively, they can keep this close. But if Penn State stalls drives and forces turnovers, they will control the tempo.

Injuries and Conditions

Oregon Ducks

RB Noah Whittington is expected back after missing recent games.

Penn State Nittany Lions

No major injury reports surfaced.

Game environment: Beaver Stadium’s White Out will be electric. No weather concerns expected.

Best Bets and Prediction

Projected score: Oregon 28, Penn State 24 (52 total)

Best bet: Oregon +3.5
Secondary lean: Over 52.5

The Ducks’ offensive explosiveness and efficiency give them value as underdogs. Expect a tight, high-intensity game.

Handicapping Angle

Check out top picks in our Service Plays and follow expert results on the Handicapper Leaderboard. Strategy and betting insights are in the Bettors Handbook.

Penn State Nittany Lions vs Oregon Ducks Picks and Predictions September 27th 2025