Colts vs Rams NFL Week 4 Preview

Los Angeles Rams vs Indianapolis Colts September 28th 2025

The Indianapolis Colts will visit the Los Angeles Rams in Week 4 of the 2025 NFL season. The game is set for Sunday, September 28, at SoFi Stadium in Inglewood, California. Fans can catch the action on FOX at 4:05 PM.

The Colts come into this game with a perfect 3-0 record. Head Coach Shane Steichen leads the team, with Jim Bob Cooter and Lou Anarumo as coordinators. The Rams, led by Head Coach Sean McVay, hold a 2-1 record. Both teams aim to improve their standings early in the season.

Colts vs Rams Key Information

Sport: Football
Teams: Indianapolis Colts vs. Los Angeles Rams
Venue: SoFi Stadium in Inglewood, CA USA
Date: Sunday, September 28, 2025
Betting Odds: Colts Moneyline +155, Rams Moneyline -184, Colts Spread +3.5 (-113), Rams Spread -3.5 (-107), Total Over 49.5 (-110), Total Under 49.5 (-111)

The Colts Can Win If…

The Indianapolis Colts are coming off a strong 41-20 win against the Tennessee Titans. Jonathan Taylor was a standout with 102 rushing yards and three touchdowns. Daniel Jones added 228 passing yards and a touchdown, while Michael Pittman Jr. contributed with 73 receiving yards and a touchdown.

The Colts have a solid offense with strong rushing and passing capabilities. They rank first in rushing yards this season, thanks to Jonathan Taylor’s performance. Their passing game is also effective, with Daniel Jones ranking first in passing yards among QBs.

Defensively, the Colts have shown they can force turnovers, with a top-five rank in interceptions last season. Tyquan Lewis and Kenny Moore II are key players on this defense. With their balanced attack and solid defense, the Colts have the tools to win their next game.

The Rams Can Win If…

The Los Angeles Rams are coming off a close game against the Philadelphia Eagles, where they lost 33-26. Despite the loss, the Rams had more first downs than the Eagles, with 22 compared to 19. Running back Kyren Williams led the ground game with 94 rushing yards, while wide receiver Puka Nacua caught 11 passes for 112 yards.

The Rams’ offense has shown strong potential this season. They rank 10th in passing yards from the last season, which is a testament to their air attack. Quarterback Matthew Stafford has passed for 739 yards in three games, ranking 9th in the league, which could be a key factor in their favor.

On the defensive side, the Rams have been effective in forcing turnovers. Last season, they ranked 7th in opponent passing interceptions and 8th in fumbles recovered. With key players like Kam Curl and Poona Ford, the Rams’ defense could make a difference in their upcoming game.

The Lean

The Colts are 3.5-point underdogs against the Rams. The model projects a tight game with the Colts winning 27-24. Given the Colts’ recent success against the spread (4-0 in their last 4 games), taking the Colts +3.5 (-113) seems like a solid pick.

The total for the game is set at 49.5. The model projects a combined score of 51 points. The Colts have hit the over in their last 5 away games. Considering both teams’ offensive and defensive stats, betting on the over 49.5 (-110) is recommended.

Colts vs Rams Preview

The Indianapolis Colts (3-0) look to extend their unbeaten start when they visit the Los Angeles Rams (2-1) in Inglewood. Daniel Jones ranks third in the league with 816 passing yards and has yet to throw an interception, while Jonathan Taylor exploded for 102 yards and three touchdowns in last week’s 41-20 win over Tennessee. Indianapolis is tied for second in scoring at 34.3 points per game.

Los Angeles let a 12-point halftime lead slip away in a 33-26 loss to Philadelphia. Matthew Stafford had a season-low 196 passing yards, while Kyren Williams paced the run game with 94 yards. The Rams’ defense still ranks fifth in yards allowed, and their 12 sacks tie for the league lead.

Injury Report

The Colts listed Kenny Moore II (Achilles), Alec Pierce (concussion), Matt Goncalves (toe), and DeForest Buckner (back) as non-participants in practice. Corner Mike Hilton could debut after signing this week.

For the Rams, Davante Adams (hamstring) and Rob Havenstein (ankle) sat out, but both appear closer to veteran rest days. Steve Avila (ankle) was limited and remains questionable after missing two games.

Betting Results and Trends

Indianapolis opened as a small road favorite on the NFL odds page. The Colts are 3-0 ATS with two Overs, showing balance on both sides of the ball. The Rams are 2-1 ATS, and their games have leaned Over thanks to strong offense paired with late defensive lapses. Both defenses rank top seven in yards allowed, which could keep totals in check.

What It Means Moving Forward

A Colts win would mark their first 4-0 start since 2009 and further validate Jones as Steichen’s offensive centerpiece. The Rams need cleaner execution in late-game situations and more consistency from Stafford if they want to stay in NFC contention.

ScoresAndStats Handicappers and Picks

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Los Angeles Rams vs Indianapolis Colts Picks and Predictions September 28th 2025