Washington Nationals vs Chicago White Sox Picks and Predictions September 28th 2025

Washington Nationals vs Chicago White Sox September 28th 2025

The Chicago White Sox will visit the Washington Nationals at Nationals Park on Sunday, September 28, 2025. The game is set to start at 3:05 PM and will be aired on MASN. The weather forecast predicts a warm day with calm winds and broken clouds.

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The White Sox, managed by Will Venable, hold a record of 59-102, placing them last in the AL Central. They have struggled recently, going 2-8 in their last 10 games. On the other side, the Nationals, led by interim manager Miguel Cairo, have a 66-95 record, also ranking last in their division. They have shown some improvement with a 4-6 record in their last 10 games. Starting pitchers for the game are Shane Smith for the White Sox and Brad Lord for the Nationals.

White Sox vs Nationals Key Information

• Sport: Baseball
• Teams: Chicago White Sox vs. Washington Nationals
• Venue: Nationals Park in Washington, DC
• Date: Sunday, September 28, 2025
• Betting Odds: White Sox Moneyline +101, Nationals Moneyline -121

Nationals vs White Sox MLB Betting Preview

The Washington Nationals (66-95) close their season at home Sunday against the Chicago White Sox (59-102). Both teams are out of contention, but rookies Colson Montgomery and Daylen Lile have kept late-season interest alive. For roster details, check the Washington Nationals team page.

Montgomery has homered in two straight and owns 21 in his first 70 career games, a shortstop rookie record. Lile has been even hotter, hitting .409 over his last 25 games and fueling Washington’s offense. For team breakdowns, see the Chicago White Sox team page.

The White Sox Can Win If…

Rookie Shane Smith (6-8, 3.98 ERA) can deliver five or more steady innings. He rebounded in his last outing vs the Yankees, holding them to one run in five frames. The White Sox lineup has been making loud contact, with 162 homers this season and Colson Montgomery’s bat anchoring the middle. If Lenyn Sosa or Montgomery provide power early, Chicago can ride its bullpen to a finale win.

The Nationals Can Win If…

Brad Lord (5-9, 4.12 ERA) keeps Chicago’s bats quiet for six innings. He’s posted a 3.13 ERA across September and has been Washington’s most reliable late-season arm. James Wood (31 HR) and Daylen Lile (.302 AVG) must stay hot to spark the offense. If Washington wins the longball battle — they’ve hit nine homers across the last two games — they have the edge.

Matchup Breakdown

White Sox: Smith has been up and down in September but showed bounce-back ability. Chicago ranks 20th in home runs but has multiple young power threats. Montgomery’s .371 average over his nine-game hitting streak is proof of his advanced bat.

Nationals: Lord has never faced the White Sox, but his recent command suggests another quality start. Washington owns a .243 team average (13th in MLB) and has shown late-season pop. James Wood and Jacob Young homered Saturday, fueling a comeback win.

See full side-by-side stats on the MLB teams page.

Injuries and Conditions

• White Sox: No new injuries, rookies Montgomery and Sosa continue to lead.
• Nationals: Healthy roster, Lile and Wood closing the year in form.

Weather: Clear fall afternoon in D.C., neutral hitting environment.

Best Bets and Prediction

Both rookies on the mound are evenly matched, so this game comes down to lineups. Washington’s power surge across the last two games tips the scales.

Projected score: Nationals 5, White Sox 4
Best Bet: Nationals moneyline -121
Lean: Over 8.5 runs (-119) — both teams’ young bats are finishing strong.

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