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Colorado Buffaloes vs Iowa State Cyclones October 11th 2025
In Week 7 of the 2025 college football season, the Iowa State Cyclones will travel to Boulder to take on the Colorado Buffaloes. The game will be held at Folsom Field, an outdoor stadium, and is set to kick off at 3:30 PM on Saturday, October 11. Fans can catch the action on ESPN.
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The Cyclones are ranked #22 in the AP Poll and #21 in the Coaches Poll. They have a strong record of 5-1 this season, with a 1-1 record on the road. On the other side, the Buffaloes have struggled with a 2-4 record, including 0-3 in conference play. Colorado will be looking to improve their home record of 2-2 in this Big 12 matchup.
Iowa State vs Colorado CFB Key Information
- Sport: College Football
- Teams: Iowa State Cyclones vs. Colorado Buffaloes
- Venue: Folsom Field in Boulder, CO
- Date: Saturday, October 11, 2025
- Betting Odds: Iowa State Moneyline -160, Colorado Moneyline +135, Iowa State Spread -3.5 (-105), Colorado Spread +3.5 (-115), Total Over/Under 52.5 (-110)
Iowa State vs Colorado – Big 12 Week 7 Betting Preview
Saturday, October 12 | Folsom Field, Boulder | ESPN2
The Iowa State Cyclones hit the road after their first loss of the season, taking on the Colorado Buffaloes in a Big 12 matchup that pits two teams with very different recent trajectories.
Iowa State aims to regroup after falling 38-30 to Cincinnati, while Colorado looks to end a three-game conference skid and get back on track under coach Deion Sanders, who is expected to return to the sideline following a minor medical procedure.
Iowa State can win if
Quarterback Rocco Becht continues his efficient play and the defense forces turnovers. Becht threw for 314 yards and two touchdowns in the loss to Cincinnati, helping Iowa State move the chains 29 times — a sign that their offensive rhythm remains strong.
The Cyclones rank 14th nationally in first downs and 28th in passing yards, proof that their offense can sustain drives and control tempo. Defensively, they’ve forced six interceptions (7th nationally), led by standout defensive back Jeremiah Cooper.
Running backs Carson Hansen and Abu Sama III provide solid balance, combining for over 500 rushing yards, while kicker Kyle Konrardy has been automatic from range. If the Cyclones protect Becht and avoid slow starts, they have the tools to control possession and wear down the Buffaloes’ defense.
Colorado can win if
Quarterback Kaidon Salter limits mistakes and the Buffaloes maintain their ground attack. Despite last week’s 35-21 loss to TCU, Colorado’s offense showed life early, rushing for 126 yards and scoring twice in the first half.
Salter has thrown for 901 yards and seven touchdowns this season but must cut down on turnovers after three interceptions against the Horned Frogs. The Buffaloes’ offensive balance could give Iowa State problems, especially at altitude, where they’ve historically performed well.
Colorado ranks 28th nationally in first downs and 15th in sacks (9), a stat that could create havoc for Iowa State’s front line. Key playmakers like Omarion Miller and Micah Welch will be critical in exploiting defensive mismatches.
If the Buffaloes protect Salter and convert red-zone trips into touchdowns, they have a legitimate shot to pull off the upset at home.
Line Movement and Odds
Opening: Iowa State -3 / Colorado +3
Current: Iowa State -3.5 / Colorado +3.5
Total: 52.5 points
The Cyclones opened as slight road favorites and have held steady after early betting support. Iowa State has been reliable after losses, covering in six of its last seven bounce-back games, while Colorado has fared well at home against the spread.
Track live odds and totals on the college football odds page. For sportsbook comparisons, visit Sportsbook Reviews or operator insights via Pay Per Head Reviews.
Matchup Breakdown
Iowa State averages 410.5 yards per game and leads the Big 12 in third-down conversions. Colorado’s defense has shown progress but continues to struggle against the run, giving up over 175 rushing yards per game in conference play.
Turnovers will likely decide this matchup — the Cyclones are +6 in turnover margin, while the Buffaloes have given the ball away nine times in their last three games. Iowa State’s efficiency and discipline make them a tough team to beat when they win the turnover battle.
For statistical matchups, recent trends, and predictive analytics, review the college football teams page or read the Expert Betting Guide for deeper data models.
Injury Report
Iowa State Cyclones
- WR Jaylin Noel (ankle) – questionable
- LB Caleb Bacon (shoulder) – probable
Colorado Buffaloes
- QB Kaidon Salter (ankle) – probable
- WR Travis Hunter (illness) – questionable
- CB Cormani McClain (discipline) – out
Weather in Boulder should be ideal, with kickoff temperatures around 68°F and light winds.
Best Bets and Prediction
Both teams have firepower, but Iowa State’s consistency and turnover margin give them the advantage. Expect Becht to continue spreading the ball efficiently while the Cyclones’ defense forces one or two key takeaways.
Prediction: Iowa State 28, Colorado 24
Best Bet: Iowa State -3.5 (-110)
Secondary Lean: Under 52.5 (-110)
For verified expert selections, visit the Best Handicappers Leaderboard or compare capper performance through the Handicappers Sites Reviews.
ScoresAndStats Betting Resources
Sharpen your game-day strategy with SAS’s trusted tools:
- Best Handicappers for verified records and premium picks
- Sportsbook Reviews to find trusted betting sites
- Expert Betting Guide for spread and total trends
- Pay Per Head Reviews for operator management insights
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