Stanford Cardinal vs Notre Dame Fighting Irish Picks and Predictions November 29th 2025

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Stanford Cardinal vs Notre Dame Fighting Irish Betting Preview

The Stanford Cardinal host the Notre Dame Fighting Irish at Stanford Stadium in Week 14 action. Notre Dame enters at 9-2 ranked No. 9 nationally, while Stanford sits at 4-7 but has won four of five at home. Bettors will weigh Notre Dame’s playoff push against Stanford’s spoiler hopes in this late-season matchup.

Line Movement and Odds

  • Notre Dame Spread: -32.5 (-110)
  • Stanford Spread: +32.5 (-110)
  • Notre Dame MoneyLine: -12250
  • Stanford MoneyLine: +2700
  • Total: 51.0 (Over -110, Under -110)

Notre Dame opened as massive favorites, reflecting their dominant win streak and Stanford’s inconsistency. See full NCAAF odds for market movement.

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Matchup Breakdown

Notre Dame Fighting Irish Outlook

Notre Dame crushed Syracuse 70-7 last week, their highest point total since 1932. QB CJ Carr has 2,536 passing yards and 22 touchdowns, while RB Jeremiyah Love leads with 1,306 rushing yards and 17 scores. RB Jadarian Price adds 659 rushing yards and 10 TDs. Defensively, the Irish rank sixth in sacks (33) and have 20 interceptions, with Leonard Moore and Tae Johnson each returning picks for touchdowns. Their balanced attack and aggressive defense make them a top-10 contender.

Stanford Cardinal Outlook

Stanford beat Cal 31-10 last week, led by QB Elijah Brown’s poise (625 passing yards, three TDs since becoming starter). RB Micah Ford has 643 rushing yards, while WR CJ Williams leads with 735 receiving yards and six scores. The Cardinal defense ranks fourth nationally in interceptions and fumbles recovered, with 23 sacks (16th nationally). Stanford is 4-1 at home, showing resilience despite being eliminated from bowl contention.

Key Matchup / Path to Victory

Notre Dame must continue their rushing dominance and defensive disruption to control the game. Stanford needs Brown and Williams to exploit Notre Dame’s secondary while forcing turnovers defensively. Ball control and red-zone execution will be decisive.

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Injuries / Availability

Notre Dame Questionables/Out: Noah Burnette (K, questionable), Gabriel Rubio (DL, out), Chance Tucker (CB, out), Billy Schrauth (OL, out), Ashton Craig (OL, out), Charles Jagusah (OL, out), Cooper Flanagan (TE, questionable), Dylan Devezin (RB, out), Kedren Young (RB, out), Kyngstonn Viliamu-Asa (LB, out), Tae Johnson (S, questionable), Peter Jones (OL, out).

Stanford Questionables/Out: Wilfredo Aybar (OLB, questionable), Jack Leyrer (OT, questionable), Tuna Altahir (RB, questionable), Nathan Mejia (OL, questionable), David Pantelis (WR, out), Jordan Onovughe (WR, questionable), Nick Fattig (OL, questionable), R.J. Gaskins (DL, questionable), Cam Richardson (CB, questionable), Javion Randall (CB, questionable), JonAnthony Hall (WR, questionable).

Environment

The game kicks at Stanford Stadium, where Stanford is 4-1 at home. Notre Dame is 3-1 on the road, looking to avoid a letdown after their historic win. Expect a charged atmosphere with Notre Dame chasing playoff positioning.

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Best Bets and Prediction

Projected Final Score: Notre Dame 56, Stanford 10

  • Best Bet: Notre Dame -32.5 (-110)
    Notre Dame’s dominance as a favorite and explosive offense suggest they can cover the large spread.
  • Total: Over 51.0 (-110)
    Our model projects 66 points, leaning over given Notre Dame’s scoring and Stanford’s defensive lapses.

Notre Dame’s rushing attack and defensive strength should secure the win, while Stanford’s home form helps them compete early. Expect a decisive Irish victory trending over the total.

Handicappers and Service Plays

Elevate your college football betting confidence by exploring expert breakdowns in our Best Handicappers, tracking late-season trends on the Leaderboard, and reviewing premium NCAAF picks in the Buy Picks section for sharper insights.

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