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Game Preview: San Francisco 49ers @ Cleveland Browns
The San Francisco 49ers travel to face the Cleveland Browns in a pivotal Week 13 showdown at Huntington Bank Field. Scheduled for Sunday, November 30, with kickoff at 1:00 PM ET on CBS, this game features two of the NFL’s most dangerous pass rushes facing off in snowy and breezy conditions.
Quarterbacks Brock Purdy and Shedeur Sanders bring drastically different levels of experience, but both are under pressure. San Francisco’s defense just held Carolina to nine points, while Cleveland rides a dominant showing over Las Vegas into this matchup.
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Odds and Key Information
| Category | Details |
|---|---|
| Matchup | San Francisco 49ers @ Cleveland Browns |
| Venue | Huntington Bank Field, Cleveland, OH |
| Date | Sunday, Nov. 30, 2025 |
| Time | 1:00 PM ET |
| Broadcast | CBS |
| 49ers ML | -239 |
| Browns ML | +197 |
| Spread | 49ers -5.0 |
| Total | 37.5 |
Be sure to reference our full NFL odds board before making your bets.
San Francisco 49ers Outlook
The 49ers (8-4) rebounded last week with a 20-9 win over Carolina. Christian McCaffrey produced 89 rushing yards and a touchdown, while Ji’Ayir Brown led a dominant defensive effort with two interceptions.
San Francisco ranks fourth in passing yards and top 10 in both first downs and third-down conversions. The defense is just as stout, led by a front line capable of pressuring any quarterback—vital in a snowy game.
Understanding how to bet on NFL games in cold-weather matchups is key. Expect a run-heavy script with a focus on ball control.
Cleveland Browns Outlook
The Browns (3-8) are coming off a 24-10 win over the Raiders, where Shedeur Sanders tossed for over 200 yards and one touchdown. Myles Garrett was dominant with three sacks and two forced fumbles, making him the defensive X-factor once again.
Cleveland’s defense is top-three in yards allowed and sacks. Offensively, they’ve struggled, but young talent like Judkins and tight end Harold Fannin Jr. are starting to show signs of growth.
For new bettors, this may be a good time to learn about prop bets on sack totals or fumbles.
Key Matchup
All eyes will be on the trenches. The 49ers offensive line must protect Brock Purdy from Garrett, who is chasing a historic third consecutive game with 3+ sacks.
For those analyzing alternate lines, understanding alternate total points is important in such volatile conditions.
Betting Trends
- 49ers are 5-0 SU and ATS after a loss this season
- Browns are 4-1 ATS at home in 2025
- Browns are 3-0 to the OVER at home
- 49ers are 5-2 ATS in road games
- Browns are 4-1 to the OVER in all 2025 games
Analyzing these alongside sports betting strategies can provide value in soft totals markets.
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Predictions
San Francisco has too much firepower and defensive structure to be upset here. The key is limiting mistakes against Garrett and forcing Sanders into third-and-longs.
Projected Score: 49ers 24, Browns 17
Spread Pick: 49ers -5.0
Total Lean: Over 37.5
Why You Need Expert Picks
This is the time of year when sharp bettors lean heavily on analytics and trusted handicappers. The Handicappers Leaderboard ranks the top NFL experts by ROI, record, and win streak.
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