The 2027 NCAA men’s South Regional is at the Frost Bank Center in San Antonio, with the Sweet 16 on Thursday, March 25 and the regional final on Saturday, March 27, 2027. No. 3 Illinois won the 2026 South, beating No. 9 Iowa 71-59 in the regional final in Houston, and no price on the 2027 region exists until the bracket is set on March 14.
The 2027 South Regional
- Venue: Frost Bank Center, San Antonio, Texas
- Sweet 16: Thursday, March 25, 2027
- Regional final: Saturday, March 27, 2027
- Final Four: April 3 and 5, Ford Field, Detroit
- Bracket: Selection Sunday, March 14; the 2027 tournament is the first with 76 teams
The four teams that reach San Antonio will come through First and Second Round sites the NCAA assigns on Selection Sunday. The regional pairs with the West, at Crypto.com Arena in Los Angeles on the same two days.
March Madness Starts Here
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How the 2026 South went
| Round | Result |
|---|---|
| Regional final, March 28 | No. 3 Illinois 71, No. 9 Iowa 59 |
| Sweet 16, March 26 | No. 3 Illinois 65, No. 2 Houston 55 |
| Sweet 16, March 26 | No. 9 Iowa 77, No. 4 Nebraska 71 |
| Second round | No. 9 Iowa 73, No. 1 Florida 72 |
| Second round | No. 3 Illinois 76, No. 11 VCU 55 |
| Second round | No. 2 Houston 88, No. 10 Texas A&M 57 |
| Second round | No. 4 Nebraska 74, No. 5 Vanderbilt 72 |
| First round | No. 11 VCU 82, No. 6 North Carolina 78 |
| First round | No. 10 Texas A&M 63, No. 7 Saint Mary’s 50 |
The Sweet 16 and regional final were at the Toyota Center in Houston, where No. 2 Houston lost to Illinois as a 2.5-point favorite. Illinois was favored by 6.5 over Iowa in the final and won by 12, on DraftKings’ closing lines as ESPN records them.
Florida, the No. 1 seed, went out in the second round, beaten 73-72 by Iowa in Tampa. Two double-digit seeds won first-round games, VCU and Texas A&M, and both lost in the second round by 21 or more.
Illinois won the South by an average of 19.5 points across four games: 105-70 over Pennsylvania, 76-55 over VCU, 65-55 over Houston and 71-59 over Iowa. It then lost 71-62 to UConn in the Final Four, and Michigan won the title.
Betting the South Regional
A regional winner price is posted once the bracket is out, on March 14, and it is a price on four straight wins. A team at +300 to win a region is priced at 25%, one at +1500 at 6.3%. A futures price is worth taking only when you rate the chance higher than the price does.
In 2026 the No. 1 seed in the South did not reach the Sweet 16, and the region was won by a No. 3. One region in one year proves nothing about the next, but it shows how much of a four-game path is left when the board first goes up.
The other regions have their own pages, the East, West and Midwest, and the Sweet 16 odds cover the whole round. The college basketball championship odds follow the 2027 title board, and our college basketball predictions start with the season. For paid picks, compare the best handicappers, and read our sportsbook reviews first.