Arizona State Sun Devils vs Houston Cougars Picks and Predictions October 25th 2025

Houston Cougars vs Arizona State Sun Devils Game Preview

The Houston Cougars visit the Arizona State Sun Devils on Saturday, October 25, 2025, at Mountain America Stadium in Tempe, AZ. Kickoff is set for 8:00 PM ET on ESPN.

No. 24 Arizona State (5-2, 3-1 Big 12) enters the week riding high after knocking off then-No. 7 Texas Tech, while Houston (6-1, 3-1) continues to quietly stack wins under first-year coach Willie Fritz. Both teams sit one game back in the Big 12 standings, giving this matchup significant postseason implications.

Check real-time market movement and updated lines on the college football odds and scores page.

Line Movement and Betting Odds

Houston Moneyline: +249
Arizona State Moneyline: -314
Houston Spread: +7.5 (-110)
Arizona State Spread: -7.5 (-110)
Total Over/Under: 47.5 (-110)

Arizona State opened as a touchdown favorite at home, and early betting action has leaned toward the Sun Devils following their upset of Texas Tech. The total has settled under 50 points, suggesting oddsmakers expect a physical, defense-heavy game.

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Houston Cougars

Houston is coming off a 31-28 home victory over Arizona, capped by Ethan Sanchez’s 41-yard game-winning field goal. The Cougars’ offense exploded for 232 rushing yards and didn’t allow a single sack, earning Big 12 Offensive Line of the Week honors.

Quarterback Conner Weigman accounted for four total touchdowns (three passing, one rushing) and ran for a career-best 98 yards. His dual-threat ability adds balance to an attack averaging over 29 points per game.

Running back Dean Connors leads the Cougars with 538 rushing yards, while wideout Amare Thomas has added 510 receiving yards. Defensively, Houston ranks top 30 nationally in scoring defense (19.0 points allowed per game) and seventh in interceptions with six.

Injury Report

Stacy Sneed (RB) – Questionable (Undisclosed)
Jayden York (TE) – Questionable (Undisclosed)
David Ndukwe (OL) – Out (Leg)
Anthony Gangi Jr. (WR) – Questionable (Undisclosed)
Stephon Johnson (WR) – Out (Undisclosed)
Devan Williams (WR) – Questionable (Undisclosed)
Keany Parks (DB) – Questionable (Undisclosed)
Re’Shaun Sanford II (RB) – Out (Undisclosed)
Luke McGary (TE) – Questionable (Undisclosed)
Larry Crawford (OL) – Questionable (Undisclosed)
Darius Washington (DL) – Questionable (Undisclosed)
Brock Foster (TE) – Questionable (Undisclosed)

Full injury report for Houston Cougars

Arizona State Sun Devils

Arizona State earned national attention with its 26-22 upset win over No. 7 Texas Tech. Quarterback Sam Leavitt returned from injury to post a career-high 319 passing yards, completing 28 of 47 passes without an interception.

Wideout Jordyn Tyson caught 10 passes for 105 yards and a touchdown before leaving with a leg injury, and his status for Saturday remains uncertain. The Sun Devils’ defense has been the backbone of their success, ranking eighth in sacks (22) and sixth in interceptions (10).

Running back Raleek Brown adds balance to the offense, ranking 17th nationally in rushing yards and giving Arizona State the versatility needed to sustain drives. At home, the Sun Devils have been unbeatable, boasting an 11-0 record in their last 11 games in Tempe

Injury Report

Ben Coleman (OL) – Out (Arm)
Xavion Alford (DB) – Out (Undisclosed)
Prince Dorbah (DL) – Questionable (Undisclosed)
Ian Shewell (DL) – Questionable (Undisclosed)
Zyrus Fiaseu (LB) – Out (Undisclosed)
Zac Swanson (DL) – Questionable (Undisclosed)
Kyson Brown (RB) – Questionable (Undisclosed)
MyKeil Gardner (DL) – Out (Achilles)
Noble Johnson (WR) – Questionable (Undisclosed)
Plas Johnson (DB) – Questionable (Undisclosed)
Jayden Fortier (TE) – Questionable (Undisclosed)
Albert Smith III (DE) – Questionable (Undisclosed)

Full injury report for Arizona State Sun Devils

Key Storylines

• Arizona State upset No. 7 Texas Tech for its first top-10 win since 2019.
• Both teams are 3-1 in Big 12 play and trail conference leaders BYU and Cincinnati by one game.
• Houston QB Conner Weigman has 17 total touchdowns with zero turnovers in his last four games.
• Arizona State has won 11 straight home games.
• Both defenses rank top 10 nationally in interceptions.

Prediction

Houston’s physical run game and opportunistic defense give it a puncher’s chance, but Arizona State’s home-field dominance and elite pass rush tilt this matchup toward the Sun Devils. Expect a close first half before Arizona State pulls away behind Sam Leavitt’s precision passing.

Projected Score: Arizona State 27, Houston 24
Best Bet: Houston +7.5 (-110)
Secondary Lean: Over 47.5 (-110)

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