Lsu Tigers vs South Carolina Gamecocks Picks and Predictions October 11th 2025

LSU Tigers vs South Carolina Gamecocks October 11th 2025

The South Carolina Gamecocks will travel to Baton Rouge to take on the LSU Tigers in Week 7 of the 2025 college football season. This game will be held at Tiger Stadium on October 11, with a kickoff time of 7:45 PM ET. Fans can catch the action on SECN.

South Carolina enters the game with a 3-2 record, including 1-1 on the road. LSU stands at 4-1, with a perfect 3-0 at home. Both teams are part of the Southeastern Conference, adding extra intensity to this matchup.

South Carolina vs LSU CFB Key Information

• Sport: College Football
• Teams: South Carolina Gamecocks vs. LSU Tigers
• Venue: Tiger Stadium (LA), Baton Rouge, LA
• Date: Saturday, October 11, 2025
• Betting Odds: South Carolina Moneyline +272, LSU Moneyline -345, South Carolina Spread +8.5 (-108), LSU Spread -8.5 (-113), Total Over 43.5 (-112), Total Under 43.5 (-109)

South Carolina vs LSU – SEC Week 7 Betting Preview

The LSU Tigers and South Carolina Gamecocks square off in Baton Rouge as both programs return from a bye week. LSU looks to rebound from a road loss at Ole Miss, while South Carolina aims to build on its dominant win over Kentucky.

This matchup opens a critical stretch for both teams in the SEC, with LSU trying to stay in the College Football Playoff hunt and South Carolina searching for its first signature road win of the season.

South Carolina can win if

The defense continues forcing turnovers and setting up short fields. The Gamecocks’ 35-13 win over Kentucky showcased their defensive strength — forcing three fumbles and two interceptions. They rank ninth nationally in sacks with 15 and are top ten in total takeaways.

Quarterback LaNorris Sellers has provided steady leadership, throwing for 163 yards against Kentucky while the offense rushed for 178 yards. Key contributors like Rahsul Faison and Vandrevius Jacobs have given the offense balance, combining for over 480 total yards and five touchdowns this season.

If South Carolina can maintain ball control, pressure LSU’s quarterback, and capitalize on turnovers, they have a realistic chance to pull off the road upset in Death Valley.

LSU can win if

They execute a complete offensive game and avoid red-zone stalls. LSU’s 24-19 loss to Ole Miss exposed inconsistency in the passing attack and lack of rhythm in the run game. Quarterback Garrett Nussmeier has thrown for 197 yards or more in four of five games but needs improved efficiency downfield.

Running back Caden Durham, expected to return from an ankle injury, adds explosiveness to a ground game averaging just 104.8 yards per contest. The Tigers’ defense remains the backbone — ranked 27th in points allowed and eighth in interceptions with 11 total sacks.

At home, LSU has been dominant under Brian Kelly, scoring 56 points in their last home game and forcing multiple turnovers. If the Tigers balance their offensive tempo and use their defensive front to pressure Sellers, they should hold serve in Baton Rouge.

Line Movement and Odds

Opening: LSU -8.5 / South Carolina +8.5
Current: LSU -9.0 / South Carolina +9.0
Total: 43.5 points

Early line movement favors LSU after reports of improved injury status, but South Carolina’s strong ATS trends on the road — 8-0 in their last eight — have kept bettors intrigued.

For updated lines, totals, and betting percentages, visit the college football odds page. You can compare sportsbook reliability using the Sportsbook Reviews directory or browse operator breakdowns on the Pay Per Head Reviews page.

Matchup Breakdown

Both teams enter with similar statistical profiles. South Carolina averages 24.8 points per game while allowing 22.4, whereas LSU scores 27.0 and gives up 19.2. The difference lies in pace — South Carolina thrives on extended drives and physicality, while LSU relies on explosive plays and turnovers.

Defensively, LSU has the edge in depth, ranking higher in takeaways and defensive red-zone stops. However, South Carolina’s front seven has produced steady pressure and could disrupt LSU’s pocket rhythm.

Explore team trends and matchup efficiency data through the college football teams page and use the Expert Betting Guide for model-based spread analysis.

Injury Report

South Carolina Gamecocks

• RB Dakereon Joyner (shoulder) – questionable
• DB O’Donnell Fortune (ankle) – doubtful

LSU Tigers

• QB Garrett Nussmeier (torso) – probable
• RB Caden Durham (ankle) – expected to play

Weather in Baton Rouge will be humid and clear, with light wind and a kickoff temperature near 75°F.

Best Bets and Prediction

This game projects as a defensive battle early before LSU’s depth and home advantage tilt the outcome. South Carolina’s pass rush should keep things close, but LSU’s red-zone execution and returning playmakers make the difference.

Prediction: LSU 27, South Carolina 20
Best Bet: South Carolina +9 (-110)
Secondary Lean: Over 43.5 (-110)

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