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Ole Miss vs South Carolina Week 10 Betting Preview
No. 7 Ole Miss returns home Saturday night looking to keep its College Football Playoff hopes alive against a desperate South Carolina Gamecocks squad. Kickoff from Vaught-Hemingway Stadium is set for 7:00 PM ET, airing on ESPN.
The Ole Miss Rebels are 7-1 overall and 4-1 in the SEC after a 34-26 win over Oklahoma. South Carolina sits at 3-5 (1-5 SEC) following a collapse against Alabama that extended its losing streak to three. Lane Kiffin called the matchup “dangerous,” and he’s right — the Gamecocks have been a tough out on the road despite their record.
You can track updated college football lines on the NCAA odds page before kickoff.
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Line Movement and Odds
Ole Miss opened as a 12.5-point favorite, and the number has held steady throughout the week. The total opened at 54.5 and moved slightly higher to 55 at most books. Moneyline prices list the Rebels around -500 and South Carolina +375.
Public betting is leaning toward Ole Miss after its win in Norman, while sharp action has shown early interest in the Gamecocks at double digits. Check the latest market updates on our college football previews section
Matchup Breakdown
Ole Miss outlook:
Quarterback Trinidad Chambliss continues to impress, throwing for 315 yards and a go-ahead TD at Oklahoma. He’s topped 250 yards in each of his first six starts with only one interception. The Rebels rank fifth nationally in passing offense and seventh in first-down rate, while Kewan Lacy’s 696 rushing yards and 12 TDs balance the attack.
South Carolina outlook:
The Gamecocks’ defense is the strength — top-15 nationally in sacks and takeaways — but the offense has struggled. LaNorris Sellers has thrown for 1,356 yards with 6 TDs, and no rusher has cracked 300 yards. To stay competitive, the Gamecocks must protect Sellers and generate turnovers to shorten the field.
Key stat: Ole Miss is 27-3 SU in its last 30 home games, while South Carolina is 8-1 ATS in its last 9 away games.
Injuries and Conditions
South Carolina
- OL Cason Henry — Questionable (undisclosed)
Ole Miss
- TE Dae’Quan Wright — Probable (undisclosed)
- WR Deuce Alexander — Probable (undisclosed)
- OL Terez Davis — Probable (undisclosed)
- S Ladarian Clardy — Probable (undisclosed)
Weather in Oxford is clear and mild, with no wind concerns — perfect football conditions.
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Best Bets and Prediction
Trends point to another cover for the Gamecocks. South Carolina is 6-1 ATS after a loss and 8-1 ATS in its last nine road games. Ole Miss, though dominant at home, could get caught in a slower pace matchup if turnovers don’t come early.
Projected Score: Ole Miss 31, South Carolina 24
Best Bet: South Carolina +12.5
Secondary Lean: Over 54.5
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For more value plays, head over to our Free NCAA Picks and study the Bettors Handbook before placing your next ticket.
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