New York Giants vs Los Angeles Chargers Picks and Predictions September 28th 2025

New York Giants vs Los Angeles Chargers September 28th 2025

The Los Angeles Chargers will visit the New York Giants in Week 4 of the 2025 NFL season. The game takes place at MetLife Stadium in East Rutherford, NJ, on Sunday, September 28, at 1:00 PM. Fans can catch the action on CBS, with the weather forecast predicting a mild day with overcast clouds and a light breeze.

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The Chargers, led by head coach Jim Harbaugh, are off to a strong start with a 3-0 record. Meanwhile, the Giants, coached by Brian Daboll, are looking to secure their first win of the season, currently holding a 0-3 record. The Chargers have a history of success against the Giants, winning their last four encounters, including a 27-22 victory at MetLife Stadium in 2017.

Chargers vs Giants Key Information

• Sport: Football
• Teams: Los Angeles Chargers vs. New York Giants
• Venue: MetLife Stadium in East Rutherford, NJ USA
• Date: Sunday, September 28, 2025
• Betting Odds: Chargers Moneyline -291, Giants Moneyline +237, Chargers Spread -6.5 (-108), Giants Spread +6.5 (-112), Total Over 44.0 (-110), Total Under 44.0 (-111)

The Chargers Can Win If…

The Los Angeles Chargers are coming off a 23-20 win against the Denver Broncos. Justin Herbert led the charge with 300 passing yards and a touchdown. Omarion Hampton added 70 rushing yards and a rushing touchdown, while Keenan Allen caught a touchdown pass.

The Chargers’ passing game is strong, ranking first in the league with 860 passing yards this season. Herbert has thrown six touchdowns and only one interception. Quentin Johnston and Keenan Allen provide reliable targets, each with three receiving touchdowns this season.

The Chargers’ defense has been solid, allowing only 301 opponent points last season, ranking them first. They also recorded 46 sacks and 15 interceptions. With players like Derwin James Jr. and Daiyan Henley leading the defense, the Chargers have a good chance to win this game.

The Giants Can Win If…

The New York Giants are looking to bounce back after their recent 22-9 loss to the Kansas City Chiefs. In that game, Cam Skattebo stood out with 60 rushing yards, a rushing touchdown, and six receptions. Despite the loss, the Giants’ defense forced two fumbles, showing their ability to create turnovers.

One reason the Giants can win is their strong rushing attack. They outgained the Chiefs on the ground with 130 rushing yards to the Chiefs’ 105. Cam Skattebo leads the team with 102 rushing yards this season, and his ability to find the end zone can be a game-changer.

The Giants also have a solid passing defense, ranked 14th in opponent passing interceptions last season. Players like Paulson Adebo and Tyler Nubin are key in the secondary. If they can disrupt the Chargers’ passing game, the Giants have a good chance to secure a win at home.

The Lean

The Los Angeles Chargers are favored by 6.5 points against the New York Giants. The Chargers have a strong ATS record, going 6-0 in their last six games. Given the Giants’ struggles, with a 2-3 ATS record in their last five games, the recommendation is to pick the Chargers to cover the spread. The projected score is Chargers 27, Giants 17.

The total for the game is set at 44.0. The Chargers have hit the over in 8 of their last 12 games. The Giants have a mixed record with the total, going 6-7 in their last 13 games. Considering the Chargers’ offensive strength and the Giants’ defensive issues, the recommendation is to take the over. The projected total is 44 points.

Chargers vs Giants Preview

The Los Angeles Chargers (3-0) visit the New York Giants (0-3) on Sunday in East Rutherford. Justin Herbert leads the league with 860 passing yards and engineered a comeback win over Denver last week. Rookie running back Omarion Hampton added 70 yards and a touchdown after Najee Harris was lost for the season with an Achilles injury.

New York turns to rookie Jaxson Dart after moving on from Russell Wilson. Dart has seen six snaps this season but has yet to attempt a pass. The Giants hope to rally behind fellow rookie Cam Skattebo, who led them in rushing and receiving against Kansas City.

Injury Report

Los Angeles will be without Harris, and also listed guard Mekhi Becton (concussion), center Bradley Bozeman (back), wideout Derius Davis (knee), and tight end Will Dissly (knee) on the injury report.

The Giants have kicker Graham Gano sidelined with a groin injury and brought in Younghoe Koo for competition. Malik Nabers (shoulder), Theo Johnson (toe), Rakeem Nunez-Roches (foot), and Tyrone Tracy Jr. (shoulder) all missed practice.

Betting Results and Trends

The Chargers opened as clear road favorites on the NFL odds page. They are 3-0 ATS, backed by a defense allowing just 16.7 points per game. The Giants are 0-3 ATS, ranked 31st in both yards and rushing yards allowed. Totals lean Under for Los Angeles thanks to defensive control, while New York’s offense remains inconsistent.

What It Means Moving Forward

Herbert has cemented his status as a franchise quarterback, but the Chargers must adapt quickly in the run game without Harris. A fourth straight win would keep them atop the AFC West. For the Giants, Dart’s debut represents more about development than results, but avoiding a fourth straight loss is critical to morale in the Daboll era.

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