Oregon Ducks vs Indiana Hoosiers Picks and Predictions October 11th 2025

Oregon Ducks vs Indiana Hoosiers October 11th 2025

In Week 7 of the 2025 college football season, the Indiana Hoosiers will visit the Oregon Ducks at Autzen Stadium in Eugene, Oregon. The game is set for Saturday, October 11, 2025, at 3:30 PM and will be broadcast on CBS. Both teams enter the game with perfect 5-0 records, making this an exciting matchup.

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The Hoosiers are ranked #7 in both the AP and Coaches Polls and have shown strong performance this season. They have a 1-0 record on the road. Meanwhile, the Ducks hold the #3 spot in the AP Poll and #2 in the Coaches Poll. They have a solid 3-0 record at home. Both teams are also undefeated in conference play, with 2-0 records. This game will be a key test for both teams as they aim to maintain their winning streaks.

Indiana vs Oregon CFB Key Information

• Sport: College Football
• Teams: Indiana Hoosiers vs. Oregon Ducks
• Venue: Autzen Stadium in Eugene, OR
• Date: Saturday, October 11, 2025
• Betting Odds: Indiana Moneyline +235, Oregon Moneyline -291, Indiana Spread +7.5 (-115), Oregon Spread -7.5 (-106), Total Over 55.5 (-107), Total Under 55.5 (-114)

Oregon vs Indiana – Big Ten Week 7 Betting Preview

Saturday, October 12 | Autzen Stadium, Eugene | ABC

The Oregon Ducks are riding the nation’s longest active regular-season winning streak as they welcome the Indiana Hoosiers for a top-10 Big Ten matchup at Autzen Stadium.

Oregon, ranked No. 3, is fresh off a double-overtime win at Penn State and enters the weekend rested after a bye. Indiana, meanwhile, sits at No. 7 after edging Iowa and continues its best start in school history at 5-0.

It’s a strength-on-strength showdown: Oregon’s top-ranked pass defense against Indiana’s balanced, explosive offense led by transfer quarterback Fernando Mendoza.

Indiana can win if

Quarterback Fernando Mendoza continues his efficient play and Indiana maintains offensive balance. Mendoza has thrown for 1,208 yards and 16 touchdowns with just one interception, while the running game has added 1,339 yards and 11 rushing scores by committee.

The Hoosiers rank sixth nationally in both points scored and rushing yards, and they’re capable of long, sustained drives. Wideout Omar Cooper Jr. (432 yards, six touchdowns) provides a consistent deep threat that stretches defenses.

Defensively, Indiana ranks eighth in sacks and third in points allowed per game (9.6). If their pass rush can disrupt Oregon’s rhythm early and limit Dante Moore’s time in the pocket, Indiana has the tools to pull off another top-10 upset on the road.

Oregon can win if

Quarterback Dante Moore remains poised and the Ducks’ defense continues its elite form. Oregon’s secondary has allowed only 123.4 passing yards per game — third-best in the nation — and has surrendered just two passing touchdowns all year.

On offense, Moore has thrown for 1,210 yards and 14 touchdowns, while running back Jordon Davison leads a ground attack that’s produced 1,201 rushing yards. The Ducks have scored on 100 percent of their red-zone trips this season (23-for-23), showing remarkable consistency in finishing drives.

If Moore protects the ball and Oregon’s front seven controls Indiana’s run game, the Ducks can extend their home winning streak to 19 games and stay perfect in Big Ten play.

Line Movement and Odds

Opening: Oregon -7 / Indiana +7
Current: Oregon -7.5 / Indiana +7.5
Total: 55.5 points

Oregon opened as a touchdown favorite and remains steady as money leans toward the home side. The Ducks have covered 13 of their last 15 games at Autzen Stadium, while Indiana has gone 7-2 ATS in its last nine games as an underdog.

For updated movement and totals, check the college football odds page. You can also compare sportsbook reliability and bonuses through Sportsbook Reviews and operator insights in Pay Per Head Reviews.

Matchup Breakdown

Oregon boasts one of the nation’s most efficient defenses, allowing just 9.8 points per game and thriving on takeaways. Their defensive backs have combined for eight interceptions and 18 pass breakups, while the front line averages nearly three sacks per contest.

Indiana counters with a high-powered offense that averages 38.4 points and 454 yards per game. The Hoosiers’ offensive line has been stout, allowing just four sacks all season — a key factor in keeping Mendoza upright against Oregon’s blitz-heavy scheme.

For deeper statistical breakdowns and betting analytics, explore the college football teams page and the Expert Betting Guide for advanced data trends.

Injury Report

Oregon Ducks

• WR Tez Johnson (hamstring) – questionable
• RB Noah Whittington (ankle) – out
• CB Khyree Jackson (foot) – probable

Indiana Hoosiers

• RB Trent Howland (ankle) – probable
• WR Donaven McCulley (knee) – questionable
• LB Aaron Casey (shoulder) – out

Weather in Eugene is expected to be cool and clear with temperatures in the mid-50s at kickoff.

Best Bets and Prediction

Oregon’s defense has been nearly impossible to throw against, and the Ducks’ red-zone perfection gives them a consistent scoring edge. Indiana’s offensive balance makes this a compelling matchup, but Oregon’s home-field advantage and extra week of rest should be decisive.

Prediction: Oregon 31, Indiana 20
Best Bet: Oregon -7.5 (-110)
Secondary Lean: Under 55.5 (-110)

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