Patriots vs Saints – NFL Week 6 Betting Preview & Predictions

New Orleans Saints vs New England Patriots October 12th 2025

The New England Patriots travel to face the New Orleans Saints in Week 6 of the 2025 NFL season. The game will take place at the Caesars Superdome in New Orleans on Sunday, October 12, at 1:00 PM. Fans can catch the action on CBS as the Patriots aim to maintain their perfect road record.

The Patriots, led by head coach Mike Vrabel, have a 3-2 record this season. They have been strong on the road, winning both away games. On the other side, the Saints, coached by Kellen Moore, hold a 1-4 record. They look to improve their performance at home, where they have won once in three attempts this season.

Patriots vs Saints Key Information

Sport: Football
Teams: New England Patriots vs. New Orleans Saints
Venue: Caesars Superdome in New Orleans, LA USA
Date: Sunday, October 12, 2025
Betting Odds: Patriots Moneyline -189, Saints Moneyline +158, Patriots Spread -3.5 (-107), Saints Spread +3.5 (-113), Total Over 46.0 (-109), Total Under 46.0 (-110)

Patriots vs Saints – NFL Week 6 Betting Preview

The New England Patriots look to keep climbing the AFC ladder as they visit the New Orleans Saints in a Week 6 matchup between two rebuilding programs trending upward.

Drake Maye has been sensational for New England, while the Saints are finding their rhythm under new head coach Kellen Moore. Both teams are looking to turn recent wins into sustained momentum heading into midseason.

The Patriots can win if

Drake Maye continues his efficient, fearless play. The rookie has thrown for 1,261 yards, leading the NFL, and has shown poise against aggressive defenses. His chemistry with Stefon Diggs (359 receiving yards) has elevated New England’s passing game into a legitimate strength.

The Patriots’ ground game remains inconsistent, but Rhamondre Stevenson’s two-touchdown effort last week against Buffalo hinted at renewed balance. With Antonio Gibson sidelined, Stevenson and TreVeyon Henderson will handle the workload against a Saints defense that ranks middle-of-the-pack in rushing yards allowed.

Defensively, New England thrives when it forces turnovers. Marcus Jones and Robert Spillane have been playmakers in key spots, and the Patriots are among the league leaders in defensive fumble recoveries. If they can generate short fields and protect Maye, the Patriots can secure another tight road win.

The Saints can win if

Their defense sets the tone early. The Saints forced five turnovers (two interceptions, three fumbles) in their 26-14 win over the Giants, a performance they’ll try to replicate at home.

Quarterback Spencer Rattler has been efficient, throwing just one interception in five games while averaging nearly seven yards per attempt. His connection with Rashid Shaheed (114 yards and a touchdown last week) gives New Orleans explosive play potential, particularly against a Patriots secondary that has been vulnerable to deep shots.

Still, New Orleans’ biggest issue remains the red zone — ranking 29th in touchdown percentage (41.2%). If Rattler and Kellen Moore’s offense can finish drives with touchdowns instead of field goals, the Saints can defend their home turf and notch their second win.

Line Movement and Odds

Opening: Patriots -2.5 / Saints +2.5
Current: Patriots -3.5 / Saints +3.5
Total: 46.0 points

New England’s strong win in Buffalo pushed early money their way. The Patriots are 3-0 ATS following a loss and 4-1 ATS in their last five as road favorites.

Stay on top of NFL line updates at the NFL odds and scores page, and find trusted sportsbooks in our Sportsbook Reviews section or Pay Per Head Reviews.

Matchup Breakdown

The Patriots’ offense ranks top 10 in passing yards, driven by Maye’s quick reads and Diggs’ veteran precision. However, the run game has lagged behind, ranking 27th in yards per game.

The Saints counter with one of the NFL’s most opportunistic defenses, ranking sixth in interceptions and top five in takeaways. They’ve allowed just 19.8 points per game despite offensive inconsistency.

Both teams enter with defensive coordinators who emphasize pressure — expect creative blitz packages and early tempo setting. For detailed team breakdowns, visit the NFL teams page or study the Expert Betting Guide for advanced analytics and betting angles.

Injury Report

New England Patriots

RB Antonio Gibson (foot) – out
S Jaylinn Hawkins (hamstring) – out
WR Tyquan Thornton (ankle) – questionable
CB Jonathan Jones (knee) – probable
OT Trent Brown (groin) – probable

New Orleans Saints

CB Isaac Yiadom (hamstring) – out
DE Chase Young (calf) – limited, questionable
WR A.T. Perry (shoulder) – probable
RB Kendre Miller (ankle) – questionable

Weather: Indoor stadium – no weather impact.

Prop Spotlight

Drake Maye Over 249.5 Passing Yards (-115)
Maye has eclipsed 260 yards in four of five starts and faces a defense ranked bottom-third in completion percentage allowed.

Rashid Shaheed Anytime Touchdown (+150)
Shaheed has developed into Rattler’s go-to deep threat, and his speed gives him an edge against New England’s secondary.

Best Bets and Prediction

Both teams are trending in the right direction, but New England’s offensive firepower and turnover creation give them the advantage. Expect a high-scoring, competitive game that comes down to the fourth quarter.

Prediction: Patriots 27, Saints 23
Best Bet: Patriots -3.5 (-110)
Secondary Lean: Over 46.0 (-110)

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New Orleans Saints vs New England Patriots Picks and Predictions October 12th 2025