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Tennessee Titans vs Indianapolis Colts
The Indianapolis Colts will host the Tennessee Titans in a Week 8 AFC South clash at Lucas Oil Stadium on Sunday, October 26, 2025 (4:25 PM ET).
The game airs on CBS, and while overcast skies are expected in Indianapolis, the roof will likely be closed for this divisional matchup.
Indianapolis enters at 6–1, the league’s biggest surprise so far, while the struggling 1–6 Titans are trying to find a spark under interim coach Mike McCoy. These teams already met earlier this season — a 41–20 Colts blowout in Nashville that set the tone for their respective trajectories.
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Line Movement and Odds
Oddsmakers aren’t giving Tennessee much of a chance here. Indianapolis opened as a double-digit favorite, and money continues to pile on the Colts given their dominant home form and Tennessee’s offensive anemia.
Current Odds:
- Titans Spread: +14.0 (-110)
- Colts Spread: -14.0 (-110)
- Titans MoneyLine: +748
- Colts MoneyLine: -1210
- Over/Under: 47.0
You can monitor live odds and line movement at the NFL scores and odds page.
The Titans Can Win If…
The Tennessee Titans must do something they’ve failed to do all season — score consistently.
Their offense ranks dead last in both points per game (13.7) and total yards (269.4), while converting a league-worst 28.3% on third down.
Still, there are glimmers of hope. Rookie quarterback Cameron Ward threw for 255 yards last week against New England, and receiver Chimere Dike showed flashes of explosiveness with 70 yards and a touchdown. Ward’s deep-ball accuracy gives Tennessee a puncher’s chance if protection holds up.
The Titans’ defense, however, is decimated. Jeffery Simmons (hamstring) and L’Jarius Sneed (quad) are both questionable, removing two of their few remaining playmakers. Without them, Tennessee’s ability to slow down Jonathan Taylor — the league’s leading rusher — is nearly nonexistent.
If Tennessee wants a miracle win, they’ll need multiple takeaways (they ranked 9th in interceptions last season) and must strike early through the air before Indy’s run game takes over. Realistically, the Titans are playing for respect — and development — not wins.
Titans Key Stats:
- 32nd in scoring (13.7 PPG)
- 32nd in total offense (269.4 YPG)
- 31st in red zone efficiency (28.6%)
- 29th in pass protection (23 sacks allowed)
For more in-depth defensive and offensive splits, visit the NFL expert betting guide.
The Colts Can Win If…
Simply put — the Colts need to keep being the Colts.
Running back Jonathan Taylor is having an MVP-caliber campaign, pacing the NFL with 697 rushing yards and 10 touchdowns. He shredded this same Titans defense earlier in the year for 102 yards and 3 scores, and there’s no reason to think that changes with Tennessee even more banged up.
Quarterback Daniel Jones is thriving under Shane Steichen’s system, completing 71% of his passes and owning a 110.3 passer rating under pressure (best in the league per PFF).
Protected by the league’s best offensive line — just 6 sacks allowed in 232 dropbacks — Jones has been efficient, calm, and opportunistic.
Defensively, DeForest Buckner anchors a group that ranks top-10 in run defense and total takeaways. If the Colts jump out early, their front seven will feast on a Titans offense that can’t pass protect.
Colts Key Stats:
- 1st in scoring (33.1 PPG)
- 1st in rushing touchdowns (16)
- 4th in total offense (408.5 YPG)
- 3rd in time of possession (33:47 per game)
If Indy stays balanced and focused, this should look a lot like their first meeting — one-sided and decisive.
Betting Trends
- Colts are 6-0 SU in their last six home games.
- Colts are 5-0 SU in their last five games as favorites.
- Titans are 5-0 to the Over in their last five road games.
- Colts are 5-1 ATS in their last six home games.
- Titans are 8-3 to the Over in their last 11 as underdogs.
- Colts have scored 30+ points in five of seven games this year.
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Prediction and Analysis
There’s no sugarcoating this matchup — it’s a massive talent gap.
The Colts’ offense is firing on all cylinders, while Tennessee’s offensive line and defensive front are shells of what they once were. Even if the Titans hang around early, Taylor and the Colts’ run game will wear them down late.
Expect another statement win from Indianapolis as their Cinderella season rolls on.
Projected Score: Colts 31, Titans 14
Best Bet: Colts -14.0 (-110)
Total Lean: Under 47.0 (-109)
To compare verified NFL experts, track ROI, and see top-performing handicappers week by week, visit the Handicapper Leaderboard — all picks are transparent and performance-verified.
