Oklahoma State Cowboys vs Iowa State Cyclones Picks and Predictions November 29th 2025

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Game Preview Iowa State @ Oklahoma State

The Iowa State Cyclones travel to Stillwater aiming to cap off their regular season with a third straight win when they face the Oklahoma State Cowboys on Saturday. Bowl positioning is on the line for Iowa State, while Oklahoma State is looking to snap a 10-game losing streak and end a difficult campaign on a high note.

Iowa State (7-4, 4-4 Big 12) enters with momentum after back-to-back wins over TCU and Kansas. The Cyclones have seen their offense come to life behind quarterback Rocco Becht and a potent ground game led by Carson Hansen and Abu Sama III.

Oklahoma State (1-10, 0-8 Big 12) has lost all of its conference games but has shown improved competitiveness over the past two weeks, dropping close contests to Kansas State (14-6) and UCF (17-14).

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Odds and Key Information

CategoryDetails
SpreadIowa State -11.5
MoneylineIowa State -420 / Oklahoma State +320
Total (O/U)43.0
LocationBoone Pickens Stadium, OK
Time & DateSaturday, Nov. 30, 3:30 PM ET
TV CoverageESPN2

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Iowa State Outlook

The Cyclones have turned a midseason slump into late-season success thanks to a revived offensive identity. Quarterback Rocco Becht has shown better command of the offense, throwing for three touchdowns last week, including two to Brett Eskildsen.

The running back duo of Carson Hansen (841 yards) and Abu Sama III (645 yards) continues to thrive behind a physical offensive line. Both backs are averaging over 5.0 yards per carry, giving Iowa State the ability to control the clock and wear down defenses.

Defensively, Iowa State is allowing just 21.1 points per game and has been strong on third downs, forcing punts on 42% of opponent possessions. That advantage should be crucial against a struggling Oklahoma State offense.

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Oklahoma State Outlook

It’s been a lost season for the Cowboys, who haven’t won a Big 12 game in 2025. However, they’ve been much more competitive lately. Close losses to Kansas State and UCF have shown flashes of a capable squad.

Zane Flores has taken over quarterback duties, passing and rushing for a touchdown last week. His development offers hope for the offense, but inconsistency in protection and a lack of big plays continue to hamper progress.

The defense, led by tackle Aden Kelley, has struggled to hold up against physical run teams—something Iowa State will test all day. Opponents are rushing for nearly 190 yards per game against the Cowboys.

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Key Matchup Table

MatchupEdge
Rushing OffenseIowa State
Passing AccuracyIowa State
Turnover MarginEven
Red Zone DefenseIowa State
Motivation FactorIowa State
Home Field AdvantageOklahoma State

Betting Trends

  • Iowa State is 5-2 ATS in its last 7 games.
  • Oklahoma State is 1-9 ATS in its last 10.
  • The total has gone under in 4 of Iowa State’s last 6 games.
  • Oklahoma State has scored fewer than 20 points in 7 of its last 9 games.
  • Iowa State has covered 3 straight road games.
  • The underdog is 4-1 ATS in the last 5 meetings.
  • Iowa State is 6-1 ATS as a favorite this season.
  • Oklahoma State is 0-6 ATS in home games this year.
  • Iowa State has outgained 4 of its last 5 opponents.

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Prediction

Iowa State has too much firepower and physicality in the trenches for Oklahoma State to handle. The Cowboys may keep it competitive early, but Iowa State’s balanced attack and superior defensive line should take over by the second half.

With Flores still gaining experience and the run defense underperforming, the Cyclones should control time of possession and pull away late.

Projected Score: Iowa State 30, Oklahoma State 13
Spread Pick: Iowa State -11.5
Total Lean: Under 43.0

Find more expert predictions in our NCAAF picks section.

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With one team surging and another limping to the finish line, Iowa State vs Oklahoma State may seem straightforward—but motivation, senior day emotions, and backup QBs can flip outcomes fast. Expert picks provide sharper edges when the intangibles matter most.

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