ES
NFL Predictions 
MLB Predictions 
NBA Predictions 
NHL Predictions 
Soccer Predictions 
Jacksonville leads the AFC South at 1-1 after two weeks of the 2026 season, and it is the favorite to win the division at +125. Houston, Indianapolis and Tennessee are all 0-2.
Three of the four teams have not won a game yet. Two of them meet on Sunday, when Houston plays at Indianapolis in the first AFC South game of the season.
Smash Your NFL Bets
With The Industry’s Best
Handicapping Membership!
AFC South standings after Week 2
| Team | W-L | Points for | Points against | Home | Road | Streak |
|---|---|---|---|---|---|---|
| Jacksonville Jaguars | 1-1 | 47 | 30 | 1-0 | 0-1 | L1 |
| Houston Texans | 0-2 | 37 | 56 | 0-2 | 0-0 | L2 |
| Indianapolis Colts | 0-2 | 53 | 74 | 0-1 | 0-1 | L2 |
| Tennessee Titans | 0-2 | 30 | 47 | 0-2 | 0-0 | L2 |
Jacksonville is the only team in the division with more points scored than allowed, 47 to 30. Indianapolis has scored the most, 53, and allowed 74.
How each team got here
The Jaguars beat Cleveland 34-10 at EverBank Stadium in Week 1, then lost 20-13 at Denver. Houston lost twice at home: 36-31 to Buffalo and 20-6 to Cincinnati.
Indianapolis lost 41-23 at home to Baltimore. A week later the Colts lost 33-30 at Kansas City on Sunday night, September 20. Tennessee has played two home games and lost them 23-10 to the Jets and 24-20 to Philadelphia.
The order was different last season. Jacksonville went 13-4 and Houston 12-5, while Indianapolis finished 8-9 and Tennessee 3-14. Liam Coen, DeMeco Ryans and Shane Steichen are back as head coaches. Tennessee is on its second: Brian Callahan was fired on October 13, 2025, and Robert Saleh was hired on January 19. The full list is on our NFL coaches fired page.
Each team page carries its schedule and next game: Jacksonville Jaguars, Houston Texans, Indianapolis Colts and Tennessee Titans.
Week 3 for the AFC South
- Texans at Colts, Sunday, September 27, 1:00 pm ET: Texans -2.5, total 42.5
- Patriots at Jaguars, Sunday, September 27, 1:00 pm ET: Jaguars -3, total 45
- Titans at Giants, Sunday, September 27, 1:00 pm ET: Giants -3, total 39.5
Lines are the median of 11 sportsbooks as of September 24, 00:10 UTC. Houston plays its first road game of the season as a 2.5-point favorite, after two losses at home. Tennessee plays away from Nissan Stadium for the first time.
AFC South division odds
| Team | Price to win the division | Chance implied by the price |
|---|---|---|
| Jacksonville Jaguars | +125 | 44.4% |
| Houston Texans | +140 | 41.7% |
| Indianapolis Colts | +510 | 16.4% |
| Tennessee Titans | +1375 | 6.8% |
These are DraftKings prices for the 2026 season, as ESPN listed them on September 24. At +125, a $100 bet returns $125 profit, and the price says Jacksonville wins the division 44.4% of the time. The four chances add up to 109.3%, and the extra 9.3 points is the book’s margin.
Houston is 0-2 and still priced at +140, a 41.7% chance against Jacksonville’s 44.4%. A futures bet is worth making only when you rate a team’s chance higher than the price does, and each team has 15 games left, six of them inside the division.
The week’s game-by-game predictions sit on our NFL predictions hub.
Picks from the site’s own handicappers are on the handicappers page.
