Week 1 of the 2025 College Football season gets underway on Thursday, August 28, and continues all the way through the Labor Day holiday and ends with TCU at North Carolina on Monday night. College football bettors got a taste of what’s to come with some Week 0 action last Saturday.

Now, it’s time to step it up. What a better way to cash a bet than with a parlay. Each and every week from now until the 2025-26 College Football Championship in January, our team of expert handicappers will offer up the best NCAAF parlays of the week.

We have a great one for you this week to start the new season. We’ve found three solid moneyline bets and a surprise ATS pick to get us started in 2025. Read on to learn more about our NCAAF parlay pick for Week 1 of the 2025 college football season.

NCAAF Parlay Picks

Team	Odds	Payout Per Leg
Alabama Crimson Tide	-575	$17.39
Southern Miss Golden Eagles	+13.5 (-115)	$119.47
Tulane Green Wave	-218	$220.14
Army Black Knights	-625	$271.36

Multiple leg parlay bets involve more risk. In building a solid multi-leg parlay, bettors should look to include bets that might otherwise have little value when betting alone. In our example above, we have Alabama as a huge -575 favorite over Florida State in Week 1. The Crimson Tide of the SEC are clearly the better team here with the Seminoles coming off a 2-10 season.

It makes little sense to risk $100 to win $17, but it works in our parlay. The same for Army, which plays FCS Tarleton State. The Black Knights, who won the AAC last year, are now -16.5-point favorites, which simply covers too many key numbers. Army and its triple option offense should be difficult to defend for Tarleton State, which actually played a Week 0 game. They beat Portland State 42-0.

Southern Miss should be a huge surprise in its opener against Mississippi State. New head coach Charles Huff brought a number of his players from Marshall to Southern Miss. The Eagles should see some instant success, even if that only means covering the spread in this one.

Tulane gets Northwestern from the Big Ten at home as a 4.5-point favorite. The line did move in favor of the Green Wave, who are at home. Instead of sweating a 5-point cover in a game Tulane should win at home, we’ll take the moneyline and add it to our parlay.

It’s not the greatest odds for a four-game parlay, but the likelihood of each leg cashing is relatively high. The end result is a four-legger at +271 odds.

College Football Parlay Picks

The following is our best parlay NCAAF picks for Week 1:

NCAAF Parlay Pick 1: Alabama -575

What is not to like about an Alabama season opener against an FSU team coming off a 2-10 season? The Crimson Tide are loaded with talent once again. Six starters return on offense and seven more on a defense that finished ninth in the nation in scoring defense, allowing opponents 18.3 points per game last season.

Ty Simpson takes over at quarterback. He’s been in the system for a few years and will have WRs Germie Bernard and Ryan Williams back as well as three starters on the offensive line. Head coach Kalen DeBoer also brought in his former OC at Washington Ryan Grubb.

The Seminoles were absolutely a train wreck in 2024. Head coach Mike Norvell’s team should be better in 2025, but beating Alabama just isn’t in the cards yet. The Crimson Tide has won its last 23 season openers in a row. That’s the second-longest streak in the FBS.

NCAAF Parlay Pick 2: Southern Miss +13.5 (-115)

The Golden Eagles went 1-11 last season and fired former head coach Will Hall after a 1-6 start. Southern Miss brings in Charles Huff whose Marshall team a year ago won the Sun Belt Conference championship. Huff brought a number of the Thundering Herd players with him.

QB Braylon Braxton was the Sun Belt Newcomer of the Year last year with 1,624 passing yards, 610 more on the ground, and 23 total touchdowns. Five of Marshall’s top seven receivers transferred in and more than half of the defensive starters will be ex-Herd players.

Mississippi State was the worst team in the SEC last year and is picked to finish last once again in 2025. Despite being under the key number of 14, the Eagles should be able to keep this one close.

NCAAF Parlay Pick 3: Tulane -218

Tulane football is no joke anymore. The Green Wave finished a 9-5 season in 2024 on the heels of 12-2 and 11-3 seasons in 2022 and 2023. Head coach Jon Sumrall led Tulane to the AAC title game in his first year with the program. He’ll have to replace a few key transfers, but he gets one himself.

Former BYU QB Jake Retzlaff takes over the offense which features Louisville transfer Maurice Turner at running back and former Alabama signee Shazz Preston at wide receiver.

Northwestern is picked to finish 16th in the 18-team Big Ten. The Wildcats went 4-8 last year and the talent level continues to drop as the team’s best players seem to always enter the transfer portal.

Tulane has won each of its last three season openers. They won each game by at least 20 points.

NCAAF Parlay Pick 4: Army -625

Army plays an FCS team, Tarleton State, this week. If you don’t know, Tarleton State is in Texas and went 10-4 last year. The Texans made the FCS playoffs, won their first round game but lost in Round 2 to South Dakota.

The Texans will travel to West Point and Michie Stadium where they will face the triple option offense of the Black Knights. Army, which won the AAC last year, has to replace a ton of starters, but they have enough talent to make life difficult for an FCS program.

Tarleton State beat Portland State 42-0 in Week 0. It’s interesting, but teams that play in Week 0 often have issues with teams that play their season opener in Week 1. Army is a huge favorite for a reason.

NCAAF Parlay Total Payout

You can find NCAAF odds for each leg of our parlay at any of the top sports betting sites. Use one of those sites or a parlay bet calculator to get the odds of your parlay bet. If you choose to include all four legs of this parlay, you will get odds of +271.

That means if you wager $100 on our four-leg parlay, the payout is $271. All four legs must cash in order for the parlay to pay out. Two of the legs – Alabama and Army – have 85-plus percent implied odds.

As mentioned earlier, it’s not a huge payout for a four-leg parlay. That’s only because there is less risk. That gives us greater likelihood of cashing this bet. The top handicappers here at ScoresandStats will offer parlay bets each and every week of the college football season.