If you’re doing any NFL betting in week nine, chances are you’re getting “the itch”. You know that feeling; the need to add an extra pick or five to your “lock” that can’t miss.

Sticking to straight bets is still the best way to sustainable success when it comes to betting on the NFL, but if you can’t stave off your inner NFL parlay demons, I’ve cooked one up that should help you out.

This week’s NFL parlay has some of the best plays you could hope for – especially since it figures to be a pretty brutal week for betting on underdogs. You can target more NFL Week 9 picks if you’d like, but if you want a winning parlay (or some plays to add to yours), I’ve got you covered.

For more insight for the week, don’t miss our Week 9 NFL predictions. With that, let’s dive into my favorite week 9 NFL parlay picks and why I think they’ll hit.

NFL Picks and Parlays

Team	Odds	Payout Per Leg
Indianapolis Colts	-175	$57.14
Detroit Lions	-8.5 (-110)	$200
San Francisco 49ers	-150	$400
Dallas Cowboys	-145	$744.83

I am playing it somewhat safe with my week 9 NFL parlay picks. I say “somewhat” because the Lions winning by nine against an NFC North foe is still not necessarily a lock. Oh, and locks in general simply aren’t a thing when it comes to betting on pro football.

Still, I love my NFL parlay for this week, and hopefully it can help you win some cash. I did hand out some Week 9 NFL underdog picks, but truth be told, this really isn’t the week for calling too many upsets.

My parlay will stick with the favorites, although I was still selective as far as which point spreads I felt comfortable attacking, while bettors are getting really good value with these moneylines.

Indy, San Fran, and Dallas all return solid value with none of their prices climbing over -175. That doesn’t make all of them guaranteed winners, but I love their chances. If you pile all of those picks together you can win close to $750 for every $100 you risk, depending on where you place your bets.

If you need extra NFL betting advice for Week 9, or the rest of the season, then check out our top handicappers today! This elite membership even offers a free trial so you can see how much value it truly offers.

NFL Parlay Picks

The following is our best parlay NFL picks for Week 8:

NFL Parlay Pick 1: Indianapolis Colts ML (-175)

My first week 9 NFL parlay pick is the Indianapolis Colts to beat the Pittsburgh Steelers. I do think Aaron Rodgers can still play, but we’ve seen multiple times this year that his defense can’t. Rodgers and co. are decent offensively, but they still lack reliable firepower, while that defense has been a major liability.

There have been nice moments for T.J. Watt and co., but too many times now the Steelers have given up crazy production through the air, or gotten gashed on the ground. In all three of their losses on the year, they’ve given up at least 31+ points, too.

In week nine they’ll be at home and I am sure they’ll give everything they’ve got, but they are welcoming an offensive juggernaut to town in the 7-1 Colts. Indy is riding a red hot Jonathan Taylor, who seems to think scoring three touchdowns on a weekly basis is just something that everyone does.

Newsflash: it isn’t. The guy is a freak and is borderline unstoppable. Heck, he is on a legit NFL MVP tear right now, and in a season where there is no other standout player to point the conversation elsewhere, he seriously might win it.

Part of that is not getting tripped up on the road by a lesser Steelers team. Short of Daniel Jones imploding, I don’t see how that happens, either. Pittsburgh has only corralled weak offenses to this point, and Indy’s might be the best in all of football.

Perhaps Pittsburgh makes a game of it, but they’re more than likely looking at their third consecutive loss this weekend.

NFL Parlay Pick 2: Detroit Lions ATS -8.5 (-110)

My next parlay pick for week nine has the Detroit Lions taking care of business against the Minnesota Vikings. I do always want to leave room for a division rivalry game being weird, but the Vikings look like a lost team that is ready to collapse.

Even if Minnesota were at full strength, I’m not sure they’d be a lock to beat this spread. They weren’t exactly clicking with either Carson Wentz or J.J. McCarthy under center, and now they may not have either of them to turn to this week.

Wentz was just placed on season-ending injured reserve due to a shoulder injury, while it remains unclear if McCarthy is ready to return from a nagging injury. At best, he may not be 100% and would be walking into a buzzsaw. And at worst, Minnesota has to go to war with the Lions with a quarterback even worse than one they’ve had so far in 2025.

I haven’t even begun talking about Detroit, either. The Lions have been pretty tough to beat at home under head coach Dan Campbell. Heck, they’ve been pretty difficult to beat no matter where they play.

Detroit comes in at 5-2 and needs to keep winning to keep pace within the Green Bay Packers, so I don’t see how they’ll falter at home against an inferior Vikings team that is hurting at the most important position.

If it helps, Detroit is 3-0 against the spread as a home favorite in 2025 and 5-2 ATS overall. Barring a magical performance from a suddenly healthy McCarthy, this feels like a spread the Lions can cover in their sleep.

NFL Parlay Pick 3: San Francisco 49ers ML (-150)

I also really like the San Francisco 49ers to get the win this week. They took a small step backward in getting shut down by the Houston Texans last week, but should be able to calibrate against a mangled New York Giants squad.

New York has some spunk, I’ll give them that. However, they are still a struggling team that is starting a raw rookie under center, and they lost their fire (Cam Skattebo) due to a gruesome leg injury last week.

The G-Men still have some offensive talent, but they’re looking at a lost season and I think they know it. Once that doubt creeps in, you start dealing with some games that will get away from you, much like we saw in a 38-20 loss to the Philadelphia Eagles in week eight.

On the other hand, the Niners are a veteran team with a soft matchup in front of them. New York has struggled immensely against both the run and the pass on the year, setting this up as a game where Christian McCaffrey could dominate.

San Francisco’s defense could also feast here, as you have to know defensive coordinator Robert Saleh is licking his chops over how his pass rush could rattle Dart. If that happens even a little bit, life will be made easier on the 49ers, who – by the way – just might get some reinforcements with the likes of Brock Purdy and Ricky Pearsall possibly due back.

NFL Parlay Pick 4: Dallas Cowboys ML (-145)

The Dallas Cowboys continue to be one of the most frustrating  NFL teams to bet on, but the offensive upside forever remains. They didn’t get it done last week in a crushing blowout loss to the Denver Broncos, but anytime Dak Prescott and co. are greeted with a favorable spot, bettors need to pounce.

I think they get that this week, as they’ll be at home to host the weak Arizona Cardinals on Monday Night Football. Prescott has thrived in spots like these, while Dallas has the speed to kill on their home turf.

Dallas still has major flaws defensively and Arizona could get quarterback Kyler Murray back, but none of that is enough to get me off the ‘Boys at home. Dallas is the far more cohesive team from an offensive perspective, while the Cardinals are not threatening enough on defense to stifle both CeeDee Lamb and George Pickens through the air.

This game does have shootout potential, but this is a game Dallas has to have as they look to prevent a brutal slide in the NFC playoff race. Arizona has lost each of their last five games following a shocking 2-0 start, and I think they’re headed for a sixth defeat in a row.

NFL Parlay Total Payout

• Indianapolis Colts (-175)
• Detroit Lions -8.5 (-110)
• San Francisco 49ers (-150)
• Dallas Cowboys (-145)

Be sure to shop around for the best possible NFL odds for each of these games, as the pricing is bound to be a little different across numerous sports betting sites.

As a reminder, I do suggest targeting all bets straight up, so even pairing two bets together for the smallest parlay possible is discouraged. In the name of upside, though, I love all four of my week 9 NFL parlay picks, and think we’ve got a four-pack of winners here.

If I had to stand by one pick this week, it’d be the 49ers. They offer killer value at -150 and I have zero faith in the Giants. San Francisco has been the better team all year, they have more to play for, they’re getting healthy at the right time, and the Giants are hurting badly due to a mounting injury list.

If you are loving these NFL parlay picks, then check out our College Football parlays of the week and double down on this weekend’s gridiron action.