Three weeks into the 2025 season and already some heads are starting to roll. In case you missed it, UCLA got absolutely stomped by New Mexico 35-10 in a very sparsely populated Rose Bowl last Friday night. That left the Bruins at 0-3 and the administration promptly fired head coach Deshaun Foster.

Foster was not the only casualty in Week 3. Virginia Tech lost 45-26 to Old Dominion on Saturday. It was the Hokies third straight loss … all at home! The higher-ups in Blacksburg had enough and decided to fire head coach Brent Pry three-plus mediocre seasons. Pry’s best season was a 7-6 campaign in 2023.

Who’s next? There are a number of high profile games this week, starting with the No. 17 Texas Tech at No. 16 Utah Big 12 clash on Saturday at noon. The Red Raiders lead the nation in scoring while the Utes are one of the top defenses in the country.

Auburn travels to Oklahoma and Illinois is at Indiana in two other matchups of ranked opponents in Week 4. The next coaching casualty could come out of Saturday night’s Florida-Miami game. Gators head coach Billy Napier is on the hot seat after consecutive losses to South Florida and LSU. His 20-21 overall record doesn’t help either.

There are also a number of other high-value matchups across the Big Ten, SEC, and other conferences. We’re still quite a ways away from the College Football Playoffs picture beginning to take shape. 

Once again, our college football experts are here to bring you the best previews, picks, and predictions from Week 4 all the way to the CFB Championship. Keep it tuned to Scores & Stats all season long. You will find the best analysis and insight in the industry. On to Week 4!

College Football Week 4 Schedule

College Football Week 4 Odds

Keep an eye on the latest College Football odds from the top online betting sites and monitor how the lines change throughout the week.

There are actually a number of extremely high point spreads in Week 4. It starts with the No. 8 Texas Longhorns who will host Sam Houston on Saturday night. The Longhorns are 41.5-point favorites, but that is not the largest point spread on the board this week.

That honor belongs to the 2-0 and No. 7 Florida State Seminoles. Head coach Mike Norvell’s team is a 44.5-point favorite against Kent State, one of the worst programs in the nation. The Golden Flashes actually do have a win this season, but it was against FCS Merrimack and came as the result of a fourth-quarter kickoff return.

Tennessee has put up big numbers on offense this season. The Vols are averaging 52.7 points per game and the books expect big numbers in their game with UAB on Saturday. That game has the week’s highest total with the number set at 69.5. UAB is allowing 36 points per game through its first three.

The lowest total of the week is in Thursday night’s American Athletic Conference clash between Rice and Charlotte. Both programs have new head coaches. Both coaches have philosophies that revolve around the run, specifically option football. Expect a slower tempo game, which is why the game total is set at 42.5.

Of course, we’ll go over all of the college football week 4 point spreads and game totals when looking at all of the top matchups below. Need more advice beyond our preferred picks and predictions when betting on college football week 4 lines? Just check out the top sports betting handicappers before finalizing your bets.

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College Football Week 4 Predictions

Let’s take a look at the featured College Football Week 4 games and make our NCAAF picks for each game.

Texas Tech Red Raiders @ Utah Utes Odds

The Red Raiders have embraced the portal era better than most, overhauling their defense after a rough 2024 campaign. They added high-upside linemen like Howard Sampson and Will Jados to form what might be the Big 12’s best defensive front. The offense looks solid, with USC transfer Quinten Joyner filling in at running back and a veteran O-line that added NFL-caliber depth in Hunter Zambrano. Joey McGuire’s team is physical, aggressive, and deep, which are traits that could make them a dark-horse CFP contender if the new defensive pieces gel.

Those pieces have led to a 3-0 start and a No. 17 ranking. The Red Raiders offense is No. 1 in the nation, averaging 58 points per game. The defense hasn’t given up more than 14 points in a game yet.

Utah is banking on dual-threat QB Devon Dampier and an improved offensive line to engineer a bounce-back year. The Utes went 5-7 last season and also started 3-0 with three easy wins. Dampier has shown he can be dynamic with his arm and legs, and he’s supported by a Utah defense that is one of the stingiest in the country. Utah is allowing just 8.8 points per game (eighth in the nation).

Texas Tech Red Raiders @ Utah Utes Predictions

This is the first big test for both teams. It could very well be a prelude to the Big 12 championship game at the end of the season. Behren Morton is in full control of the Red Raiders Air Raid offense. He’ll face a defense that flies around and can slow down the Texas Tech passing game.

Can the Red Raiders slow down Dampier and the Utah running game? Running the football and defense has been Utah head coach Kyle Whittingham’s signature for years. That’s why he is 170-86 and has three conference titles in his career.

Utah plays a style of football that will allow them to control the football and keep it away from a very explosive Texas Tech offense. That will slow the pace of this game. Utah’s defense also returned five starters from last year and is off to an outstanding start. The Red Raiders offense will present a formidable challenge, but Utah ranks 15th in the nation in sacks and 10th in opponent third down conversions. Advantage Utah.

Also, in games early in a season where the two teams have scoring averages that add up to more than the game total, the Under cashes close to 60 percent of the time.

Bet: Utah -185, Utah -3.5 (-112), Under 57.5 (-110)

Oregon State Beavers @ Oregon Ducks Odds

Oregon entered the 2025 season with serious momentum, riding a 13-1 campaign and returning much of the core that made Dan Lanning’s squad a playoff contender. The Ducks are deep, physical, and disciplined, and they don’t drop regular-season games to teams they’re supposed to beat.

Their only close calls in 2024 came against ranked foes and Boise State. This is a game they should win and they’ll do it with an offense that is averaging 54 points per game (fourth in the nation) and a defense that has given up just 10 points a game.

Dante Moore is the quarterback and he appears to be a good one. He’s completed 78.1 percent of his passes for 657 yards and seven touchdowns. His stats would be even more impressive if Oregon wasn’t blowing out its opponents and Moore was actually playing full games.

Oregon State’s offense enters 2025 with some promise but a lot of unknowns. The Beavers were wildly inconsistent late last season, scoring under 20 points in four of their final five games. While RB Anthony Hankerson is a reliable workhorse (1,000+ yards, 15 TDs), the passing game struggled. Maalik Murphy, the Texas transfer via Duke, takes over at QB and brings some upside, but his weapons are largely unproven.

The Beavers are off to an 0-3 start largely because of a defense that can’t stop anyone. Oregon State has allowed at least 34 points in each of its first three games. How they stop Oregon is anybody’s guess.

Oregon State Beavers @ Oregon Ducks Predictions

This is a rivalry in name only right now. Oregon is bigger, faster, more experienced, and playing at home. Oregon State has potential in spots, but their defensive front is no match for the Ducks’ offensive line, and asking Murphy and the Beavers offense to keep pace in the Beavers’ first big test is a lot. Lanning doesn’t let his team play down to the opponent, and this one could get ugly early.

Oregon is set to get to another Big Ten title game and earn a trip to the College Football Playoff. Oregon State is just trying to get by while the Pac-12 adds some teams it can beat in the future. The Beavers are 0-8 SU the last eight times they have traveled to Autzen Stadium.

Bet: ML NA, Oregon -34.5 (-110), Over 55.5 (-108)

Michigan Wolverines @ Nebraska Cornhuskers Odds

The Wolverines’ will be tested on the road once again at Nebraska on Saturday. QB Bryce Underwood and his teammates failed the first one at Oklahoma. They bounced back last week, but it was against in-state Central Michigan. The Wolverines won that game 63-3.

Nebraska will prove a much tougher opponent, especially in Year 3 of the Matt Rhule era. If you remember, Rhule was a head coach at Temple and then at Baylor before giving the NFL a go. In Year 3 at Temple, Rhule’s Owls went 10-4 and played for an American Athletic Conference title (which they won the following season).

In Year 3 at Baylor, Rhules’ Bears went 11-3 and won the Big 12. This year’s Cornhuskers are off to a 3-0 start. They won all three games at home. Cincinnati gave Nebraska all it could handle in a 20-17 win in Week 1. The Huskers blew out Akron and Houston Christian.

QB Dylan Raiola’s development is a huge factor in Nebraska’s quest to break through in 2025. He’s got the arm talent and leadership tools to elevate the program, but consistency will be the difference. Can he outplay the Wolverines talented freshman?

Michigan Wolverines @ Nebraska Cornhuskers Predictions

This is the kind of road spot Michigan hasn’t always handled well. Nebraska’s home-field setup and favorable schedule timing put them in a great position to steal this one outright, especially if Underwood looks like he did against Oklahoma.

Nebraska has the defense to stop the Wolverines. They’ll need to slow down Michigan’s running game, but the Cornhuskers rank No. 1 in the nation against the pass. In a hostile environment, it’s going to be tough for Underwood. We’ve already seen him in a similar situation at Oklahoma.

This should be a close, low-scoring game that favors the home team. Michigan is 4-1 SU and ATS in the last five against Nebraska, but they weren’t playing a Year 3 Matt Rhule-coached Nebraska.

Bet: Nebraska +114, Nebraska +2.5 (-108), Under 45.5 (-112)

Auburn Tigers @ Oklahoma Sooners Odds

Both of these programs were looking for big bounce-back years in 2025. They are off to good starts with each program having won all of their first three games. Auburn got the big win over Baylor on the road in its season opener. The Tigers have won two blow outs since.

Oklahoma’s big win so far was in Week 2, a 24-13 win over Michigan that wasn’t even as close as the score indicates. That win was sandwiched between two other blowout wins over Illinois State and Temple.

The two schools have only played each other three times in the history of college football. Oklahoma has won all three. The most recent was last year, 27-21, at Auburn. The previous two meetings were in the Sugar Bowl, once in 2017 and the other in 1971.

Auburn Tigers @ Oklahoma Sooners Predictions

Both quarterbacks in this game are transfers who have really started strong in 2025. Jackson Arnold started nine games for the Sooners last season and would like nothing more than to deliver the upset.

John Mateer spent last season at Washington State and has made a nice transition to Oklahoma with three big wins and a ton of stats to pad his resume. Mateer was at his best when the Sooners beat Michigan at home in Week 2.

Auburn’s running game is no joke, averaging 242 yards per game. The Tigers ran for over 300 against a Dave Aranda-led Baylor defense. That running game should allow Auburn to keep this game within striking distance. While Oklahoma has the advantage of playing at home and should win, the Tigers keep it close enough to cover.

Bet: Oklahoma -250, Auburn +6.5 (-105), Over 49.5 (-108)

Illinois Fighting Illini @ Indiana Hoosiers Odds

Indiana is coming off a historic 2024 season, one that culminated in a College Football Playoff appearance and an 11-1 regular season record. Curt Cignetti’s arrival sparked immediate success, with his up-tempo scheme turning Indiana into a legitimate football school seemingly overnight. The Hoosiers didn’t just win, they were dominant. Their only two losses came against the teams that played for the national title, Ohio State and Notre Dame.

Cignetti did lose some talent, starting with QB Kurtis Roarke. Indiana dipped into the transfer portal again to snag former California QB Fernando Mendoza. He’s been outstanding so far this season. Mendoza is completing 72.4 percent of his passes. He’s thrown for 708 yards and nine touchdowns so far this season.

Illinois is also on the rise. After a 10-win season and a Citrus Bowl victory, the Illini entered 2025 as a consensus top-15 team in preseason polls. They return 16 starters, including quarterback Luke Altmyer and a host of NFL-caliber talent like linebacker Gabe Jacas and tackle JC Davis.

The program reloaded at wide receiver, adding Hudson Clement from West Virginia and looking for a breakout year from 4-star recruit Malik Elzy. With a favorable Big Ten schedule and serious defensive depth, Illinois has a real shot to contend again.

Illinois Fighting Illini @ Indiana Hoosiers Predictions

This line opened at Indiana -2.5 and has moved all the way to the Hoosiers -4.5. Both teams have veteran quarterbacks who lead very good offenses that can run the football as well as throw it. The key for both teams, though, is defense.

Both teams rank among the top 15 teams in the nation in terms of scoring defense. Both teams also rank among the top 40 in terms of total defense. Illinois proved it could beat a good team on the road with a 45-19 win at Duke.

Indiana has proven that it has replaced the talent they lost from last year. They cruised to a 73-0 win over Indiana State last Friday night. That gave the Hoosiers an extra day of prep for Saturday’s game. With the Hoosiers at home in a game that has Big Ten and CFP implications right now, give the edge to the home team.

Bet: Indiana -192, Indiana -4.5 (-112), Over 52.5 (-108)

Washington Huskies @ Washington State Cougars Odds

This line on this game opened over the summer at Washington -11.5. Look at where it’s at now! That tells you all you need to know. Both Oregon State and Washington State are kind of in limbo right now with the Pac-12 waiting to add teams next year. That makes it tough to recruit.

The Cougars are 2-1, but both of their wins are against FCS teams. One of those was a 13-10 victory over Idaho. In their first game against an FBS opponent, the Cougars got walloped 59-10 by North Texas on the road.

Under Jedd Fisch, the Huskies are looking to quickly regroup from last season’s 5–7 stumble that followed a shocking run to the National Championship Game in 2023. Despite losing most of their top-end NFL talent, Washington was way more competitive than their record suggested. Five of their seven losses came by one score, and they were a missed two-point conversion from a bowl bid.

With Fisch importing some of his core Arizona players and quarterback Demond Williams Jr. looking like a potential star, the Huskies have a clear plan and reason for optimism. The Huskies are off to a 2-0 start. One of the wins was over FCS UC-Davis. The other was a 38-21 win over Colorado State.

Washington Huskies @ Washington State Cougars Predictions

This game feels like a mismatch on paper. Washington returns more talent, has more continuity at quarterback, and has a better overall infrastructure. It will be tough for the Cougars to keep up with Williams and the Washington offense.

You can bet the Washington staff watched what North Texas did to Washington State’s defense. Williams is a special athlete. He’s completing nearly 70 percent of his passes and he’s the team’s second-leading rusher behind Jonah Coleman. Coleman is an awesome talent himself and has seven touchdowns already in just two games.

Washington simply has too much talent compared to their Apple Cup rivals. The Huskies will do most of the damage, but expect a higher-scoring game. The Over trends for both teams. Five of the last five Washington games and six of the last eight Washington State games have gone Over the total.

Bet: ML pass, Washington -20.5 (-105), Over 53.5 (-105)

Florida Gators @ Miami Hurricanes Odds

This might be the best Florida team in years, but unfortunately for Gators head coach Billy Napier, this is also the most talented Miami team in years.

After enduring one of the roughest four-year stretches in program history, Napier seems to finally have the depth and talent to stabilize things in Gainesville. The offensive line is solid, the defense improved dramatically at the end of last season, and quarterback DJ Lagway is a star in the making. Still, Napier is 0-10 against ranked teams, and the Gators’ biggest weakness has been beating quality opponents in recent years.

That seems to be holding true as Napier and the Gators have lost two consecutive games to a ranked South Florida team and to No. 3 LSU last week. Things don’t get any easier with No. 4 Miami on Saturday night.

Florida Gators @ Miami Hurricanes Predictions

Miami’s defense is the real thing. In the offseason, head coach Mario Cristobal hired former Minnesota defensive coordinator Corey Hetherman. He led one of the best defenses in the country last year and he’s doing the same thing at Miami this season.

The Hurricanes just held South Florida to 12 points and blew the Bulls out 49-12. That’s the same Bulls team that beat Napier’s Gators 18-16 in Week 2. Miami’s offense is led by transfer Carson Beck who has transformed himself into an elite quarterback once again.

At home in prime time, Miami gets it done and might send Napier packing depending upon the damage done on Saturday night. Miami is 13-3 SU in its last 16 games and 9-0 SU at home. A lot of bettors won’t like the Miami -305 on the moneyline, but find another favorite in the -200 to -275 range and you’ve got yourself a nice two-team parlay that will pay -101 to -123.

Bet: Miami -305, Miami -7.5 (-110), Over 51.5 (-110)

Best College Football Week 4 Bets

Each week throughout the 2025 NCAAF season, the ScoresandStats college football experts put their heads together and come up with their best bets. Of the 7 to 10 games previewed each week, our handicappers will pick two or three of the bets they feel most confident in. Week 4’s best bets are as follows:

• Michigan @ Nebraska Cornhuskers +2.5 (-108)
• Miami Hurricanes -7.5 (-110)
• Utah Utes (-185)

Michigan did not play well on the road at Oklahoma. It’s always difficult away from home with a true freshman quarterback. Bryce Underwood was 9-for-24 in that game. Nebraska is in Year 3 of the Matt Rhule era. Year 3 is the year when his previous programs really got going.

The Cornhuskers defense is actually No. 1 in the nation against the pass right now. With the help of the home crowd, Nebraska slows down the Wolverine running game and covers the spread. Don’t be surprised if they pull the outright upset.

Florida is a mess right now and Miami is on the rise. The Gators have lost two straight to ranked opponents – South Florida and LSU – and Napier is just 4-15 against teams that are ranked in the AP Top 25. The Hurricanes are at home and on a roll. They’re defense is legit too.

Texas Tech has an outstanding offense, but have they played an elite defense? Arkansas-Pine Bluff, Kent State, and Oregon State hardly qualify. The Red Raiders will get a taste of what elite defense is this week. Utah is among the best in the country. Plus, the Utes have a running game that can control the football.

If you parlay all three of this week’s best bets, then a $100 bet returns approximately $466. That’s almost a 5x on what is a strong parlay card. If you want more parlay action, check out our best College Football parlays of the week.