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NFL Week 1 Picks – Expert Handicappers on Spreads, Totals, and Money Lines
What do the top NFL experts from Scores and Stats say about Week 1? Which underdog is a must-back this week? Check your favorite NFL team’s schedule, then log in now to discover the expert picks you don’t want to miss!
Ready to make confident NFL picks? Which three must-see teams should you lock in right now? Explore the latest NFL picks below, and visit our members’ area to see which teams are primed to win and cover the spread—all backed by our proven expert handicappers!
2025 NFL Week 1 Schedule
The 2025 NFL regular season is set to begin with a thrilling Week 1 slate packed with divisional rivalries, international matchups, and playoff-caliber showdowns.
From the NFL Thursday night opener in Philadelphia to Monday Night Football in Chicago, fans and bettors alike can gear up for a full weekend of action. Below is the complete Week 1 schedule, including game dates, times, and locations to help you plan your football weekend.
| Date | Matchup | Time (ET) | Location |
|---|---|---|---|
| Thursday, Sept 4 | Dallas Cowboys @ Philadelphia Eagles | 8:20 PM | Lincoln Financial Field, PA |
| Friday, Sept 5 | Kansas City Chiefs @ Los Angeles Chargers | 8:00 PM | Corinthians Arena, São Paulo, Brazil |
| Sunday, Sept 7 | Tampa Bay Buccaneers @ Atlanta Falcons | 1:00 PM | Mercedes-Benz Stadium, GA |
| Sunday, Sept 7 | Pittsburgh Steelers @ New York Jets | 1:00 PM | MetLife Stadium, NJ |
| Sunday, Sept 7 | Miami Dolphins @ Indianapolis Colts | 1:00 PM | Lucas Oil Stadium, IN |
| Sunday, Sept 7 | Carolina Panthers @ Jacksonville Jaguars | 1:00 PM | EverBank Stadium, FL |
| Sunday, Sept 7 | New York Giants @ Washington Commanders | 1:00 PM | FedExField, MD |
| Sunday, Sept 7 | Arizona Cardinals @ New Orleans Saints | 1:00 PM | Caesars Superdome, LA |
| Sunday, Sept 7 | Cincinnati Bengals @ Cleveland Browns | 1:00 PM | Cleveland Browns Stadium, OH |
| Sunday, Sept 7 | Las Vegas Raiders @ New England Patriots | 1:00 PM | Gillette Stadium, MA |
| Sunday, Sept 7 | San Francisco 49ers @ Seattle Seahawks | 4:05 PM | Lumen Field, WA |
| Sunday, Sept 7 | Tennessee Titans @ Denver Broncos | 4:05 PM | Empower Field at Mile High, CO |
| Sunday, Sept 7 | Detroit Lions @ Green Bay Packers | 4:25 PM | Lambeau Field, WI |
| Sunday, Sept 7 | Houston Texans @ Los Angeles Rams | 4:25 PM | SoFi Stadium, CA |
| Sunday, Sept 7 | Baltimore Ravens @ Buffalo Bills | 8:20 PM | Highmark Stadium, NY |
| Monday, Sept 8 | Minnesota Vikings @ Chicago Bears | 8:15 PM | Soldier Field, IL |
NFL Handicapping Leaderboard
With the 2025 NFL season right around the corner, anticipation is reaching a fever pitch—and so is the urgency to make smart, informed picks. Our Top Handicappers are locked in and ready to tackle Week 1 with the same precision and strategy that made them stand out last season.
This year’s leaderboard is more than just a ranking—it’s the result of months of offseason research, matchup analysis, and sharp betting insight. As the new season kicks off, bettors can gain a real edge by keeping an eye on expert performance and identifying trends from those who consistently deliver.
NFL Week 1 Picks
Scores and Stats top sports experts have revealed their Week 1 NFL picks against the spread, over/under, and money lines. And they offer some interesting betting opportunities, that you can bet straight up or wrap up into a winning parlays or teaser.
Kick Off the Season with Expert Picks from Scores and Stats
Kick off the 2025 NFL season with sharp analysis, proven strategies, and expert picks from Scores and Stats. Whether you’re a seasoned bettor or just starting out, our data-driven insights and real-time updates will help you make smarter, more confident decisions from Week 1 through the Super Bowl.
At Scores and Stats, we’re more than just a picks platform—we’re a growing community of fans, bettors, and analysts who live for the game. Stay connected and get daily updates, betting tips, and behind-the-scenes content by following us on Instagram @scoresandstats, X @scoresand_stats, and YouTube, where we break down the biggest matchups and share expert advice.
We’re proud to be your go-to source for NFL betting coverage. From odds and injury updates to in-depth game previews, we’re committed to providing content that’s clear, accurate, and actionable. Your feedback helps us improve every step of the way, and we’re always listening.
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