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Los Angeles Lakers vs Minnesota Timberwolves Betting Preview
The Minnesota Timberwolves continue their homestand Wednesday night at Target Center, hosting the Los Angeles Lakers on October 29, 2025. Tip-off is set for 9:30 PM ET on ESPN. Both teams are 2-2, and both are navigating injuries early in the season.
Minnesota coach Chris Finch is improvising without star guard Anthony Edwards, who’s out with a hamstring injury. Julius Randle is being used all over the floor — handling the ball high, playing the post, and facilitating from the elbow. His versatility is keeping the Wolves offense afloat.
The Lakers are also shorthanded. LeBron James and Luka Dončić are out, forcing Austin Reaves to shoulder a bigger scoring load. He’s poured in 92 points over his last two games, including a 41-point effort in a loss to Portland.
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Line Movement and Odds
Minnesota opened around –2.5 but climbed to –7.0 (–110) as public money backed the home team. The Timberwolves sit near –278 on the moneyline, while the Lakers are around +225. The total is holding at 224.5.
Public bettors are leaning Wolves, but sharp action has appeared on the Lakers +7.0 given the injury uncertainty. If you monitor market shifts closely, our NBA Previews section tracks updates from sportsbooks in real time.
Matchup Breakdown
Minnesota outlook: With Edwards sidelined, Randle leads the offense. He’s averaging 27 points over his last two games while the Timberwolves rank among the league’s top five in limiting opponent shot attempts. Expect more playmaking from him and Jaden McDaniels, who’s shooting over 60%.
Los Angeles outlook: The Lakers still score efficiently, ranking near the top of the league in field-goal percentage. Reaves has embraced a leadership role, and center Deandre Ayton has been dominant on the glass. Their ability to sustain shooting efficiency without their stars will decide this one.
Both teams met last week in Los Angeles, where the Lakers won 128-110 behind Reaves’ 25 points and 11 assists. Minnesota will try to flip that script at home.
You can follow more analytical breakdowns through the Bettors Handbook for trends and systems before tip-off.
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Injuries and Conditions
Minnesota Timberwolves
- Anthony Edwards – Out (hamstring)
- Jaylen Clark – Questionable (calf)
Los Angeles Lakers
- LeBron James – Out (sciatica)
- Luka Dončić – Out (finger, leg)
- Gabe Vincent – Out (ankle)
- Maxi Kleber – Out (abdominal)
- Jaxson Hayes – Questionable (patellar)
- Marcus Smart – Questionable (quadriceps)
See full details on the Minnesota Timberwolves injury report and the Los Angeles Lakers injury report
Best Bets and Prediction
ATS Trend: The Lakers are 6-2 ATS in their last eight as underdogs of +6 or more. The Timberwolves are 2-5 ATS in their last seven as home favorites.
Projected Score: Timberwolves 120, Lakers 115.
Best Bet: Lakers +7.0
Secondary Lean: Over 224.5
The Lakers’ efficient shooting and bench depth can keep them close, and both offenses point toward a higher-scoring game.
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