The picture of the  CFB Championship is starting to come into focus. Some big title contenders have already been knocked around, and a few surprise teams have stellar records, showing they’re potentially for real. It’s anyone’s guess who will ultimately square off in the 2025-26 College Football Playoffs, but week six is another chance for everyone to prove themselves.

With the college football week 6 odds out at most online sportsbooks, let’s dive into my top picks and predictions to help you win some bets.

College Football Week 6 Schedule 

College Football Week 6 Odds 

The College Football odds are constantly changing, to be sure to monitor the lines throughout the week. 

Going into week 6, there aren’t a lot of surprises based on pricing. The majority of the top 10 teams are big betting favorites at the top sports betting sites, but we do have some interesting battles that could go either way.

One of the most compelling matchup among Top 25 teams in week six is easily a clash between the Texas Longhorns and Florida Gators. Despite not being ranked, the Gators are only 7.5-point dogs. They could easily make this one interesting, possibly registering as one of the better values of week six.

An even bigger showdown awaits in week six, where Notre Dame hosts Boise State. This is a clash between two Top 10 teams – the only such battle this week – but it has a huge 15.5-point spread, with the Fighting Irish pulling in as the favorites.

You may have to wait for more week six college football odds to drop, but you can bet on those games early, and before long there will be live lines for every single game.

I’ll run through the best Top 25 games for week six and offer my preferred picks and predictions. If you want even more advice before placing your week 6 CFB bets, though, be sure to check out what the top sports betting handicappers have to offer.

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College Football Week 6 Predictions

Let’s take a look at the featured College Football Week 6 games and make our NCAAF Picks for each game. 

West Virginia Mountaineers vs. BYU Cougars Odds 

The West Virginia Mountaineers will visit the BYU Cougars in week six, giving fans just the third ever meeting between these two programs. West Virginia holds a 2-0 series advantage to this point, having won the most recent meeting in 2023.

West Virginia Mountaineers vs. BYU Cougars Predictions

BYU is the 17th ranked team in the nation and they’re at home, so they’re definitely expected to come away with the win here. The Cougars were quite good (11-2) a year ago, when they put up over 30 points per game and led all of college football in takeaways per game.

West Virginia is unranked and wasn’t nearly as good last year (6-7), finishing in the middle of the B12 Conference. They did have a good offense, though, so it wouldn’t be that shocking if they gave their conference foe a run for their money.

I still like BYU to win, but West Virginia ATS and the Over should be promising wagers to target.

Bet: BYU Cougars to Win

Kentucky Wildcats vs. Georgia Bulldogs Odds 

The Kentucky Wildcats have endured a rough history against the Georgia Bulldogs, and they’ll be looking up at a 64-12-2 deficit as they head into week six.

Georgia has obviously dominated the series, but it’s worth noting that they won by just one point (13-12) when these two sides met in 2024. In fact, the Wildcats kept it close (16-6) in 2022, although their 2023 win (a 51-13 Georgia victory) may be closer to the expectation for this showdown.

Kentucky Wildcats vs. Georgia Bulldogs Predictions

The Kentucky Wildcats were one of the worst teams in the stacked SEC in 2024, finishing just 1-7 in the conference and going 4-8 overall. Naturally, they are sizable road dogs against a legit title threat like Georgia.

The Bulldogs come in as the #2 team in the country. They’ve endured a lot of roster turnover over the past couple of years, but they’re extremely well-coached with loads of tantalizing prospects to build with.

Ultimately, Kentucky shouldn’t pose much of a threat. I’d be hammering the Bulldogs on the ML and spread in week six.

Bet: Georgia Bulldogs to Win

Syracuse Orange vs. SMU Mustangs Odds 

There is not a rich history between the Syracuse Orange and the SMU Mustangs. The two sides have met just one time ever, with Syracuse prevailing way back in 1932.

Syracuse Orange vs. SMU Mustangs Predictions

The Orange are ranked 21st in the country and SMU is a Top 10 team. This gives us a rare battle between two Top 25 squads, although SMU will understandably come in as the clear favorite.

Syracuse was a top 20 scoring offense a year ago, leading the country in passing yards per game. Their prolific ways give them a shot in this matchup, but we know SMU (13th in scoring in 2024) is even better offensively.

The Mustangs are the better team and are at home, but the Orange can sling it. I like their chances to keep this one interesting, while this is a game that should offer plenty of points.

Bet: SMU Mustangs to Win

Vanderbilt Commodores vs. Alabama Crimson Tide Odds 

The Vanderbilt Commodores will face the Alabama Crimson Tide in week six, in what will be the 85th meeting between these two sides.

As one would imagine, Alabama has dominated (60-20-4) throughout history, but Vanderbilt did upset them in a wild finish in 2024 (40-35). That is likely a blip on the radar, of course, seeing as Alabama won a combined 114-3 in the previous two meetings.

Vanderbilt Commodores vs. Alabama Crimson Tide Predictions

Vanderbilt was among the worst teams in the SEC in 2024 and that probably won’t change this year. A week six date with a superior Crimson Tide team shouldn’t help matters, either.

The Commodores do a solid job of taking care of the football through the air, but they are a middling team against one of the top CFB teams out there. Alabama did lose some major weapons in the NFL Draft, but their coaching and recruiting continue to put them among the best of the best.

I fully expect Alabama to take care of business at home, getting the win and easily covering.

Bet: Alabama Crimson Tide to Win

Texas Longhorns vs. Florida Gators Odds 

Arch Manning leads his Texas Longhorns into the swamp to battle the Florida Gators this week. Texas coasted to a big 49-17 win when these two teams met last year, but this is shockingly just the fifth meeting ever.

The two sides weirdly last met way back in 1940, while Texas owns a commanding 3-0-1 series advantage. The point spread for this game, however, indicates this one could be closer than what we saw a year ago.

Texas Longhorns vs. Florida Gators Predictions

Arch Manning is a Heisman hopeful, but if he wants to secure the hardware he needs to find ways to win games like this. It’s a tough setting on the road against a Florida team that may be unranked, but still went 8-5 overall and 4-1 outside of the brutal SEC in 2024.

Their ticket to success in this one is likely going to be getting to Manning. Florida has a capable enough offense, but their pass rush (15th best sack rate) is their best shot at leveling the playing field.

Manning has an array of weapons to put to use here, though, so if he can simply stay on his feet, I expect him to have enough success to get the win and most likely also cover.

Bet: Texas Longhorns -7 (-110)

Penn State Nittany Lions vs. UCLA Bruins Odds 

The Penn State Nittany Lions and UCLA Bruins have had a short but competitive history. The Bruins hold a mild 4-3 series advantage, but this will be just the eighth meeting ever.

The most recent meeting was a lopsided 27-11 win for Penn State in 2024, but this season’s showdown will be just the second time these two sides have battled since 1968.

Penn State Nittany Lions vs. UCLA Bruins Predictions

The Nittany Lions have title aspirations this year, as they once again have an explosive offense, as well as one of the stingiest defenses in all of college football.

Drew Allar has been one of the best quarterbacks in the college ranks the past two years, and his presence has allowed Penn State’s passing attack to flourish (top 20 pass rate in 2024). He hasn’t had to do it alone, though, as he also has one of the country’s more potent ground games.

Across the board, I don’t see how UCLA stops the Nittany Lions. They weren’t able to do it last year despite having a solid defense, and they still don’t have the offense to keep up if Penn State is able to put points on the board.

Penn State is an easy pick to get the win, and it’s likely they run away with this one for the second year in a row.

Bet: Penn State Nittany Lions to Win

Minnesota Golden Gophers vs. Ohio State Buckeyes Odds 

The Minnesota Golden Gophers and Ohio State Buckeyes give us a fun Big 10 battle in week six, but the “fun” part all depends on which side you’re rooting for.

The defending champion Buckeyes will be large favorites once again after cruising past Minnesota (37-3) last year, while they’ve largely dominated in a series they lead 47-7, all-time.

Minnesota has had some solid offensive teams that have given Ohio State a scare in the past, but the Gophers last stole a win way back in 2000.

Minnesota Golden Gophers vs. Ohio State Buckeyes Predictions

The Buckeyes don’t need a big sales pitch. They are a top three team in the nation no matter who you ask, they’re the defending champs, and they haven’t lost to Minnesota in over 20 years.

The Gophers were respectable enough (8-5) a year ago, but still not close to being on par with Ohio State. They could always hope to keep it close thanks to a number of key players Ohio State lost during the off-season, but Minnesota had a top-10 scoring defense last year and still had no answer.

Don’t expect things to be much different in week six. Ohio State is a lock to win, and they should do so fairly easily against their “rival”.

Bet: Ohio State Buckeyes to Win

Boise State Broncos vs. Notre Dame Fighting Irish Odds 

The Boise State Broncos and Notre Dame Fighting Irish give us a fun week six showdown featuring two top-10 squads. Despite that, Boise State is a large underdog in a matchup they’ve never had the luxury of enjoying.

This will be the first meeting ever between these two sides, and with Notre Dame being the large favorite at home, it’s understandable to lean their way.

Boise State Broncos vs. Notre Dame Fighting Irish Predictions

Notre Dame continues to go rogue and stay away from restrictive conference play, but as we know, that just means they can’t mess up during the regular season.

The Fighting Irish certainly didn’t do much of that in 2024, when they had an elite 11-2 record, and they shouldn’t get tripped up too much this year. That includes a likely home win against the Broncos, who dominated the Mountain West in 2024, but that isn’t saying a whole lot.

Boise State is still not an easy opponent, though. They didn’t lose a single game inside their conference last year, and they had a top-10 scoring offense. This is a big step up in terms of level of competition, but they’ve routinely fared well in similar spots.

I don’t think Boise State gets the upset, but this spread feels awfully thick given how talented and well-coached the Broncos are. I like them to beat this spread and give Notre Dame a scare.

Bet: Boise State Broncos +15.5 (-110)

Miami Hurricanes vs. Florida State Seminoles Odds 

The Miami Hurricanes and Florida State Seminoles will meet for the 70th time in week six. The two have waged war in the ACC for quite some time, and their overall series has been extremely competitive.

Miami does hold the upper hand (36-33) at the moment, and they also won last year’s meeting (36-14) pretty easily. However, Florida State won the previous three meetings and the Hurricanes don’t have star quarterback Cam Ward to bail them out anymore.

Miami Hurricanes vs. Florida State Seminoles Predictions

Ward’s departure in the NFL Draft could very well set Miami back a bit. They had college football’s most potent offense (42.9 points per game) a season ago, but losing several key contributors is likely going to lead to some steep regression.

Naturally, they will be an underdog in more games this year, and a road date against a team that knows them so well is unsurprisingly one of them. The Seminoles didn’t put up much of a fight in this matchup in 2024, though, and this is the absolute worst team in the ACC we’re talking about here.

Florida State should be improved and Miami stands to take a step back, but this line still feels a bit odd. I don’t mind backing Miami to beat the spread in this one.

Bet: Miami Hurricanes +7 (-110)

Clemson Tigers vs. North Carolina Tar Heels Odds 

The Clemson Tigers will take on the North Carolina Tar Heels on the road in week six in what will be the 60th battle ever between these ACC squads.

Despite the rich history, these two teams last met in 2023. Clemson won that game by 11, and has won six straight in the series.

Clemson Tigers vs. North Carolina Tar Heels Predictions

North Carolina is an unranked opponent, but they played Clemson pretty well last year and they’re at home. The Bill Belichick effect could always play into the Tar Heels rising up unexpectedly in certain spots such as these, too.

That said, Clemson has more talent on their roster, and this is a game they’re expected to win. They were still very good in this conference last year, and had one of the best passing games in the nation. Cade Klubnik put up 36 touchdowns through the air, and there’s little to suggest he won’t have loads of success against a UNC team that was 89th in points allowed per game and 90th in passing yards allowed per game.

The deciding factor could be North Carolina’s pass rush. They were a nasty unit in 2024 (4th best sack rate), and if they can get to Klubnik early, it could complicate things. Even so, Clemson has the far better offense and keeping up with them will be a big ask.

Clemson feels like a lock to win and they look like a safe bet to cover as well.

Bet: Clemson Tigers -13.5 (-110)

Best College Football Week 6 Bets

There are a plenty of worthwhile week 6 college football picks to wager on, but the following are my best bets for the week:

• Texas Longhorns -7 (-110)
• Boise State Broncos +15.5 (-110)
• Clemson Tigers -13.5 (-110)

It’s a bit early, so all of the week 6 NCAAF odds aren’t up just yet. You can expect odds for the other top college football teams in short order, though. I still like quite a few bets already, with the three listed above taking the cake.

Texas is a title contender with Arch Manning under center, as it’s a tad surprising to see this spread so tight despite the Longhorns facing an unranked opponent. I think Florida can keep it close for a bit, but expect Texas to pull away and beat this spread.

On the flip side, Boise State is a lot better than anyone ever seems to give them credit for. They are projected to get housed by Notre Dame, but I anticipate a closer game. I think they can keep this thing within two touchdowns.

Clemson is another favorite with a large spread, but one they should be able to cover. Winning by two touchdowns is never easy, but they know the Tar Heels well and North Carolina isn’t as good as they were when these two sides met in the ACC title game a few years ago.

You can parlay these three week 6 college football picks together, or target them in isolation.