We learned quite a bit more about some college football teams last week. Penn State might be broken and Arch Manning in no way, shape, or form belongs in any discussion that even mentions the Heisman Trophy.

Ohio State continues to hold on to the No. 1 spot in the latest AP Top 25 rankings. No. 2 Miami handled Florida State in Week 6 and moved up a spot to No. 2. Oregon, Ole Miss, and Texas A&M round out the new Top 5.

We get more ranked versus ranked action this week with three games featuring six teams all ranked in the latest AP Top 25. College football Saturday in Week 7 kicks off with top-ranked Ohio State visiting No. 17 Illinois. In another Big Ten clash or ranked opponents, No. 7 Indiana travels west to play at No. 3 Oregon. The final ranked versus ranked game pits eighth-ranked Alabama at No. 14 Missouri.

It’s hard to believe that we’re almost halfway through the 2025 college football season. Conference games dominate the schedule. The playoff picture is a little different than what we thought it would be at this point in the season. Both Penn State and Texas now have two losses and both teams are no longer in the AP Top 25.

As stated a few months ago, plenty will change between the start of the 2025 college football season and mid-October. It has. We’ve seen upsets and we’re likely to see more. Will there be any in Week 7?

If you missed the fireworks from Week 6, catch up on those results before diving in. And as always, keep tabs on the latest College Football Championship odds and the evolving College Football Playoff race as the season unfolds.

College Football Week 7 Schedule

College Football Week 7 Odds

Keep an eye on the latest College Football odds from the top online betting sites and monitor how the lines change throughout the week.

It’s the heart of the conference schedule for most teams and, as a result, we don’t see as many large point spreads. However, No. 4 Ole Miss does host Washington State in a non-conference game on Saturday. The Cougars are 3-2, but one of those wins was over FCS Idaho and the other was their last win over 1-4 Colorado State.

In the totals market, there are a few extremes. The Red River Rivalry pits Oklahoma and Texas with a total of 42.5, which shows the respect the books have for both defenses. That game is not the lowest total on the board, however.

That honor goes to Iowa and Wisconsin, two more very good defensive football teams. The Badgers are also struggling with quarterback issues. They started their No. 3 quarterback in last week’s 24-10 loss to Michigan.

The books also see Air Force-UNLV as one of the highest-scoring games on tap in Week 7. The Falcons have one of the worst defenses in the country, allowing 37.8 points per game (fifth-most in FBS).

That isn’t the highest total on the board though as Arkansas and Tennessee are sitting at 68.5 right now. The Vols lead the country in scoring, averaging 51 points per game. The Razorbacks are in the Top 25, averaging 37.4 per game.

Our experts will run through the best games for Week 7 and offer preferred picks and predictions. If you want even more advice before placing your week 7 CFB bets, though, be sure to check out what the top sports betting handicappers have to offer.

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College Football Week 7 Predictions

Let’s take a look at the featured College Football Week 7 games and make our NCAAF Picks for each game.

Ohio State Buckeyes @ Illinois Fighting Illini Odds

This is a one-sided rivalry, but the two teams haven’t played since 2017. The Illibuck, a wooden turtle, is awarded to the winner each year. Over the last nine meetings (yes, one win was vacated but the Buckeyes did win the game in 2007), that wooden turtle has belonged to the Buckeyes. In fact, Illinois has just one win since 2002.

Getting one this year will be difficult. As good as Illinois has been in recent years under head coach Bret Bielema, the Illini have still lost those last nine games all by double digits. They are a double-digit underdog heading into this one.

Ohio State Buckeyes @ Illinois Fighting Illini Predictions

Illinois comes into this game having won four of its previous five games and riding a two-game winning streak. QB Luke Altmyer had a strong game in their most recent 43-27 victory over Purdue. He completed 19 of 22 passes and added a touchdown to his season total. With 1,573 passing yards this season, Altmyer has proven to be a dependable leader for the Fighting Illini.

Ca’Lil Valentine (323) and Kaden Feagin (316) lead the ground attack. WR Hank Beatty has 569 receiving yards this season and has become a key target. The offense averages 37 points per game and should present a challenge for the OSU defense.

Ohio State enters this game on a high note after starting the season with a perfect 5-0 record. The Buckeyes dominated Minnesota with a 42-3 victory in their most recent game. Julian Sayin  led the offense, completing 23 of his 27 passes and throwing three touchdowns. Sayin has already thrown for 1,313 yards in five games.

RB Bo Jackson has amassed 360 rushing yards so far this season while Jeremiah Smith leads the team with 463 receiving yards. The Ohio State offense is also explosive, averaging 37.4 points per game. Keep in mind, the Buckeyes averaged 35 points per game with Will Howard at quarterback.

Ohio State is 9-0 SU and 8-0-1 ATS in its last nine games. The Illini haven’t beaten the Buckeyes since 2002. The Buckeyes have covered two of three double-digit spreads this season. The other was a push.

Bet: ML pass, Ohio State -15.5 (-110), Over 50.5 (-112)

Alabama Crimson Tide @ Missouri Tigers Odds

Alabama is 6-2 against Missouri all-time. Since the Tigers joined the SEC in 2012, the Crimson Tide have won all five games between the two schools. Alabama won last year 34-0 in Tuscaloosa.

Missouri’s two wins in the series came in the first two games. The first was in the 1968 Gator Bowl and the second was a regular season game in 1975. All six Alabama wins have been by double digits.

Alabama Crimson Tide @ Missouri Tigers Predictions

Alabama QB Ty Simpson has thrown for 1,478 yards with 13 touchdowns with just one interception. RB Jam Miller leads the Alabama rushing attack with 182 rushing yards and 1 rushing TD.

The Crimson Tide offense can score at any moment and averages 36.4 points per game. The passing offense is one of the best in the country averaging 325.4 yards per game. The Alabama defense is equally as good. The Tide allows just 285.8 yards and 16 points per game.

Missouri enters this game undefeated and seeks to make a statement at home. Their ground game is one of the key strengths this season. Ahmad Hardy leads the nation in rushing with 730 yards on 103 carries and 9 rushing touchdowns. Missouri averages 292 yards per game on the ground. That’s third-best in the nation.

Tigers QB Beau Pribula, a Penn State transfer, has been outstanding. He has completed 75.9 percent of his passes and thrown for 1,203 yards, nine touchdowns. He has thrown just three interceptions.

If you think Alabama is impressive, Missouri’s offense averages 45.2 points per game and the defense gives up 203.8 yards and 14.6 points per game. Last year, Missouri was a 16-point underdog. Now, they are a 3-point home dog. That’s telling you something and it’s why we like the home underdog.

Bet: Missouri +130, Missouri +3 (-110), Over 52.5 (-115)

Indiana Hoosiers @ Oregon Ducks Odds

These two teams have met exactly three times in the history of college football. The first two meetings came in 1963 and 1964. Both of those games were won by Oregon.

The most recent meeting between the two teams came in 2004. Indiana won that game 30-24. With Oregon’s move to the Big Ten, these two teams will play each other more often in the future. This year’s game will have a huge impact on the Big Ten championship and the college football playoff picture.

Indiana Hoosiers @ Oregon Ducks Predictions

Oregon comes into this game fresh off a five-game winning streak and undefeated start to the season. In a game where quarterback Dante Moore really showed off, the Ducks defeated Penn State 30-24 in double overtime two weeks ago. Moore demonstrated his accuracy and composure under duress by completing 29 of his 39 pass attempts and throwing three touchdown passes.

Moore has established himself as the head of Oregon’s explosive offense with 1,210 passing yards so far this season. With running backs Dierre Hill Jr. and Jayden Limar, who have rushed for 270 and 232 yards, respectively, Oregon has discovered a dependable one-two punch on the ground. Dakorien Moore, who has 296 receiving yards, has become a top target in the receiving corps and keeps opposing defenses off balance.

The Ducks average 46.6 points per game, a notable improvement over last year’s 35.7 per game. They will face a very good Indiana defense that is third in the nation, allowing just 9.6 points per game.

On offense, the Hoosiers are led by QB Fernando Mendoza. He had a strong game in the Hoosiers’ hard-fought 20-15 victory over Iowa two weeks ago. He completed 13 of his 23 passes for two touchdowns and one interception.

Mendoza has amassed 1,208 passing yards in those first five games. The running game is also strong with RB Roman Hemby’s 351 yards on the ground and fellow running back Kaelon Black’s 344 rushing yards. The Hoosiers offense has been just as explosive as Oregon, averaging 47.8 points per game in their first five games.

It is difficult for Big Ten teams to travel from west to east or vice versa in this case. However, Curt Cignetti will have Indiana prepared. In games like this with two outstanding offenses but also two very strong defenses, the defenses usually are the difference. That’s why it’s advised to lean on the Under.

Bet: ML pass, Indiana +7.5 (-110), Under 54.5 (-112)

Oklahoma Sooners @ Texas Longhorns Odds

The first game in the series was played in 1900. The Sooners and Longhorns have played 120 times and Texas leads 64-51-5. The game is typically played on the second Saturday in October. The game has gone by many names but is currently known as the AllState Red River Rivalry.

The teams have traded wins over the last three years. Texas won in 2024 by a score of 34-3. Going back to 2010, Oklahoma has dominated the series. The Sooners have won 10 of the 15 regular season meetings. Oklahoma also beat Texas in the Big 12 championship game in 2018.

Oklahoma Sooners @ Texas Longhorns  Predictions

The Texas Longhorns, whose defense is still playing football at championship level despite the offense’s incapacity to keep up, need to make a statement in this year’s Red River Rivalry. The Longhorns have only given up three passing touchdowns this season and are among the top teams in the country in terms of rushing yards allowed.

Their front seven can dominate the line of scrimmage and give Oklahoma quarterback Michael Hawkins Jr. fits. Hawkins will start again in place of the injured John Mateer. Last week, Hawkins led OU to a 44-0 win over Kent State.

Texas QB Arch Manning has 16 touchdowns, but he has played himself out of the Heisman Trophy conversation. Oklahoma may have the best defense in the country and they will make life miserable for Manning. While Texas is fifth (12.0 ppg) in scoring defense this season, the Sooners are No. 2 (7.2 ppg).

OU is No. 5 against the run and No. 2 against the pass. Florida held Texas to 52 yards rushing last week and the Longhorns managed 21 points. The Sooners are much better than the Gators on defense.

What’s interesting though is the total of 42.5. It just might be too low. Last year, the Longhorns held an awful Oklahoma offense to just three points. In the nine years prior to 2024, the Red River Rivalry went way Over 42.5 points.

Bet: Oklahoma +120, Oklahoma +3 (-115), Over 42.5 (-108)

Michigan Wolverines @ USC Trojans Odds

This is a rivalry rekindled since the Trojans joined the Big Ten. Years ago, these two teams met in a number of Rose Bowls back when the Big Ten champion would play the Pac-8, -10, or -12 champion. USC leads the all-time series 6-5.

The two teams did meet last year in Ann Arbor. Michigan pulled out a 27-24 victory last year as a 4-point underdog. The most recent prior meeting came in the 2007 Rose Bowl. USC prevailed that day 32-18.

Michigan Wolverines @ USC Trojans Predictions

Freshman QB Bryce Underwood has completed 77 of 130 passes for 1,003 yards, three touchdowns, and just one interception for Michigan. Justice Haynes leads the rushing attack with 654 rushing yards and eight touchdowns on 85 carries, but the heart of MIchigan football is its defense.

The Wolverines are seventh in the nation against the run (77 ypg) and allow just 16.2 points per game. Michigan will have its hands full with what is probably the nation’s best passing game.

USC QB Jayden Maiava has thrown for 1,587 yards, 11 touchdowns, and just one interception in five games. The Trojans offense is explosive and runs it just as well as they throw it. RB Makai Lemon has rushed for 537 yards and the Trojans average 227 rushing yards per game.

Makai Lemon is the top receiver with 589 yards and five touchdowns on 35 receptions. USC can beat you in a number of different ways. If USC has a weak spot it’s the pass defense. They rank 29th against the run but 111th against the pass. Underwood will have to find a way to exploit the Trojans pass defense.

On the other side, the Wolverines’ secondary will be put to the test by the Trojans’ passing and tempo. Michigan’s physical front might cause USC issues in the trenches. USC has scored more than 30 points in four of their last five games, and the Trojans seem to have more offensive potential because of their home field advantage and talented quarterback. Michigan will have to try and slow the game down and keep the ball away from an explosive USC offense. Easier said than done. This game favors the home favorite.

Bet: USC -135, USC -2.5 (-112), Over 57.5

Georgia Bulldogs @ Auburn Tigers Odds

It’s the Deep South’s Oldest Rivalry. Georgia and Auburn have played 129 times, including every year since 1944. Georgia leads the series 65-56-8 and has won the last eight games in a row. Auburn has just three wins in the rivalry since 2006.

The last eight wins by Georgia have all been by a touchdown or more. Six of the eight wins have come by double digits. The Bulldogs have covered the spread in nine of the last 12 meetings with the Tigers.

Georgia Bulldogs @ Auburn Tigers Predictions

Auburn comes into this game on a two-game losing streak. The Tigers lost 16–10 to Texas A&M last week. In that game, quarterback Jackson Arnold completed 18 of his 33 pass attempts. He has thrown for 846 yards this season. Jeremiah Cobb is the leading rusher with 403 rushing yards and Cam Coleman is the top receiver with 255 receiving yards.

The Tigers offense has improved from last year, averaging Auburn 27.6 points per game. The Tigers are still looking for their first conference win of the season and need one to stay alive in the SEC and playoff races.

Georgia has won four of its first five games this season. Last weekend, the Bulldogs defeated Kentucky 35–14. In that game, QB Gunner Stockton threw for one touchdown, completing 15 of his 23 pass attempts. Stockton has demonstrated his ability to move the ball through the air by throwing for 1,047 yards so far this season.

Georgia’s offense is averaging 34.6 points per game, which is an uptick from last season. This is a tough conference matchup for the Bulldogs. Both teams are very good defensively. Both defenses rank in the top 20 against the run and in the top 35 in scoring defense. Neither team allows more than 18 points per game. With the spread at -3.5, expect a low-scoring, defensive battle.

Bet: Georgia -170, Auburn +3.5 (-115), Under 46.5 (-115)

Arizona State Sun Devils @ Utah Utes Odds

These two Big 12 opponents have a relatively long history dating back to the 1960s. Arizona State leads the series 23-12, but Utah has won four of the last five meetings. The Sun Devils won last year’s game 27-19, its first win over Utah since 2018.

As mentioned, Utah has won four of the five against Arizona State. The Utes are also 5-1 ATS the last six times they have played the Sun Devils at home.

Arizona State Sun Devils @ Utah Utes Predictions

Showing remarkable late-game toughness, Arizona State enters Salt Lake riding a four-game winning streak. QB Sam Leavitt has been reliable, throwing for 1,039 yards, eight touchdowns, and just three interceptions. His relationship with WR Jordyn Tyson, who leads the team with 483 receiving yards and seven touchdowns on 39 catches, has been crucial.

RB Raleek Brown has 506 yards on 77 carries and provides balance in the backfield. With back-to-back road victories over Baylor and TCU, the Sun Devils are primed to get back to the Big 12 championship game. The Sun Devils’ ability to convert on third down may keep the Utes’ defense on the field longer than it would like, but up front, pass protection will be put to the test against Utah’s aggressive front.

After getting stomped by Texas Tech at home, Utah bounced back last week with a commanding 48-14 victory at West Virginia. QB Devon Dampier is 111 for 153 passing and has thrown for 1,027 yards and 11 touchdowns. He is leading a very productive offense that is centered on running the football. Utah ranks ninth in the nation in rushing, averaging 242.6 yards per game.

The Utes’ defense continues to be the foundation of the team’s success. They rarely give up big plays and are led by edge rusher John Henry Daley, who has 6.5 sacks. Utah has demonstrated excellent two-way consistency this season. The offense averages 39 points per game while the defense gives up 14.6.

This game is likely to be decided on third down and in the trenches. The offensive tempo of Arizona State may put strain on Utah’s secondary, but field position and pace should be determined by the Utes’ defensive front. Utah’s home-field advantage could be the difference.

Bet: Utah -205, Arizona State +5.5 (-110), Over 48.5 (-108)

Best College Football Week 7 Bets

• Oklahoma Sooners +3 (-115)
• Missouri Tigers +3 (-110)
• USC Trojans (-135)

Despite John Mateer being out for Oklahoma, Michael Hawkins Jr. proved he can lead the Sooners offense. Remember, he did start four games last season and is a former four-star high school recruit.

On the other end, the Sooners defense is going to make life very difficult for Texas QB Arch Manning. Texas had issues last week against Florida expect similar results this week and for the Sooners to cover.

Alabama has been playing extremely well since its season-opening loss to Florida State. The passing offense is among the nation’s best as is the defense. But, on the other side, Missouri may actually be better, and the Tigers are playing at home. Last year, Missouri was a huge underdog with a backup quarterback playing. Now, they are +3 home dogs with outstanding quarterback play from Beau Pribula.

Traveling west is no joke for these Eastern and Midwest teams in the Big Ten. Michigan will have a tough time slowing down USC’s high-octane offense. Even with one of the better defenses in the country, the Trojans pull out the win

If you want to place all three of these Week 7 picks into an NCAAF parlay, then you would win a staggering $521 on a $100 wager. That’s a 6x on your investment. If you want more parlay action, check out our best College Football parlays of the week. For the NFL bettors, we also have an NFL parlay of the week.