It’s like Christmas all over again for the rabid college football fan gets another heavy dose of mid-week action. The MAC continues its play on Tuesday night to kick the week off. Week 11 is the first of MAC-tion as it is known and it’s the first hint that the 2025 college football season is nearing its end.

Week 12 continues the meat of the conference schedules. It’s loaded with SEC, Big Ten, Big 12, and ACC matchups that will go a long way in determining which teams get to play for their respective conference titles. Those teams will also likely have an inside track to the 2025 College Football Playoffs.

These final weeks of the regular season are super important. Teams with their eyes on a conference championship or a berth in the playoffs cannot afford an upset loss at this point in the season.

As we look ahead to Week 12 of the college football schedule, make sure you are checking ScoresandStats on a daily basis from now until the college football national championship game. Our NCAAF experts will continue to provide inside analysis, free picks, game predictions, and more!

College Football Week 12 Schedule

College Football Week 12 Odds

Keep an eye on the latest College Football odds from the top online betting sites and monitor how the lines change throughout the week.

Most college football Week 12 lines are not available yet, but sportsbooks will start posting them closer to the start of the 2025 season and closer to Week 12.

Make sure you check ScoresandStats top handicappers each week of the college football season. They can help you understand how to approach some of these big point spreads and game totals.

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College Football Week 12 Predictions

Let’s take a look at the featured College Football Week 12 games and make our NCAAF picks for each game.

Clemson Tigers @ Louisville Cardinals Odds

These two teams have only started playing each since Louisville joined the ACC. That’s a total of nine games. The Cardinals got their first-ever win over the Tigers just last year, a 33-21 upset at Clemson. Louisville covered as an 11-point underdog and went on to win and cover in four of their last five games last season.

Clemson finished 10-4 last year, but the Tigers were just 6-8 ATS. Part of that problem was due to a defense that just didn’t get it done last season.  As a result, head coach Dabo Swinney hired Tom Allen (formerly of Penn State) to be the Tigers new defensive coordinator. Allen will have six starters and a number of quality transfers to work with.

The bigger thing for Clemson is the return of QB Cade Klubnik, who finished 10th in the nation in passing yards with 3,639 to go along with 36 touchdowns, which was third. The Tigers offense is in good hands.

Clemson Tigers @ Louisville Cardinals  Predictions

Both offenses should be in good hands. Along with Klubnik, Clemson returns eight offensive starters from last season. The Tigers finished in the top 20 in scoring (34.7 ppg) and total offense (451.9 ypg). They should be just as dangerous in 2025.

Louisville will start a new quarterback, Miller Moss, former starter at USC. Cardinals head coach Jeff Brohm has a long track record of getting the most out of his quarterbacks. Moss should be fine. He’ll have WR Chris Bell back as well as a pair of talented running backs – Isaac Brown and Duke Watson – who combined for 1,770 rushing yards last year.

The difference in this game should be defense. Clemson’s defense will be better in 2025 and, by this point in the season, Allen should have them playing well. The Cardinals defense returns four starters and will have issues with what should be one of the best offenses in the FBS.

Bet: Clemson Tigers (-210), Clemson -5.5 (-110), Over 60.5 (-110)

Texas Longhorns @ Georgia Bulldogs Odds

Could this be a preview of the CFP national championship? Anything is possible. These are two teams that should be right in the thick of the SEC race and both are favored to earn spots in the College Football Playoffs. Most experts like the Longhorns not only to win the SEC, but also the national title.

It is the first year of Arch Manning at quarterback for the Longhorns. He should do fine. Many have him projected as All-SEC in his first season as the starter. By this time in the season, he should be much sharper than early on.

As much as modern college football is about offense, for these two teams, it’s about defense. Last season, Texas finished No. 2 in the country in scoring defense, allowing opponents 15.3 points per game. Georgia was 24th (21.9). Expect both defenses to be very good in 2025. That’s why you see a line of less than a field goal in this game.

Texas Longhorns @ Georgia Bulldogs Predictions

The Longhorns are an elite defense. They return six starters and four of them are projected as first-team All-SEC players. That includes CB Malik Muhammad and S Michael Taaffe. Georgia will continue to break in QB Gunner Stockton who started the Bulldogs bowl/playoff game against Notre Dame. Only three other offensive starters return for Georgia.

The Georgia defense, however, is littered with 5-star prospects and future NFL draft picks. Head coach Kirby Smart will simply reload, despite only having three starters from last season’s unit. This is the Bulldogs final SEC game of the season and they’ll likely need a win in order to have a shot at the conference title game.

Georgia won last year 30-15 at Texas in a surprisingly dominant victory. That will bring the revenge factor into play. Texas was a 3-point home favorite last year. Now, the Bulldogs are a 2.5-point home favorite in 2025. If this number gets to 3, it’s a definite play against the spread and don’t be surprised if the Longhorns win the game outright.

Bet: Texas Longhorns +2.5 (-110)

Florida Gators @ Ole Miss Rebels Odds

This is the make or break year for Gators head coach Billy Napier. Florida heads into this game after playing at Kentucky last week. The Gators will face one of the toughest schedules in the FBS. They’ll face LSU, Miami, Texas, Texas A&M, and Georgia before taking on the Rebels here in Week 12.

Napier and Florida finished strong last year with four wins to close the season. With eight offensive starters and five defensive starters back this season, expectations are high. The defense really improved over those final four games, allowing 17 points or less in each. With QB D.J. Lagway returning, the offense should take another step forward.

Lane Kiffin and Ole Miss went 10-3 last season. One of those losses was at Florida. You can bet that 24-17 defeat late last season is eating at Kiffin, since it cost the Rebels a shot at a playoff spot last season. The issue for Kiffin is that he’ll have to replace 18 of the 22 starters from last season.

Florida Gators @ Ole Miss Rebels Predictions

One of the surprises in the SEC this season should be Ole Miss QB Austin Simmons. He’s a left-hander who needs some polish, but he’ll have some skilled wide receivers to work with. Harrison Wallace III transferred from Penn State, De’Zhaun Stribling comes over from Oklahoma State, and Cayden Lee (874 receiving yards last year) are in place.

What many may not realize is that the Rebels had the fourth-best scoring defense (15.6 ppg) in the country last year. Only two starters are back, most of the 52 sacks they recorded are gone. Still there is enough talent here to rebuild.

Florida has won each of the last three in this series. Ole Miss hasn’t beaten Florida at home since 2002. The two teams played in opposite divisions, so they didn’t play every year, but you can bet that Kiffin will want to stick it to the Gators after last season’s loss.

Bet: Ole Miss Rebels (NA)

South Carolina Gamecocks @ Texas A&M Aggies Odds

Texas A&M joined the SEC in 2012 and since then these two teams have played 11 times. The Aggies have won nine times, but they have beaten the Gamecocks every single time they have visited Kyle Field in College Station.

The Gamecocks have won two of the last three meetings, including last year’s 44-20 blowout of the Aggies. Both of those South Carolina wins were in Columbia. The Gamecocks did go 3-1 on the road in the SEC last season.

The loss to South Carolina last year started an ugly spell for Texas A&M last season. The Aggies were 7-1 heading into last year’s game against the Gamecocks. Texas A&M would lose four of its final five games of the season to end up 8-5. You can bet head coach Mike Elko doesn’t want to let that happen again in 2025.

South Carolina Gamecocks @ Texas A&M Aggies Predictions

The Gamecocks do have QB LaNorris Sellers back as well as freak WR Nyck Harbor. Sellers is a big-time dual-threat guy who threw for 2,534 yards and 18 TDs and ran for 674 more and another seven scores. The Texas A&M defense will have its hands full.

Last year’s Aggies were not a typical Elko-coached defense. They finished 39th in the nation, allowing 23.3 points per game. That’s not terrible, but it’s not good enough for Elko. He will actually take back the calling of the defense this season and he’ll have eight starters back. You can bet the pass defense will be better. Texas A&M finished 13th in the SEC in pass defense.

The Aggies were 2-1 in true SEC home games last season. They’ve won all of their home games against South Carolina (5-0) and their defense should be one of the brighter surprises in conference this season.

Bet: Texas A&M Aggies (NA)

Penn State Nittany Lions @ Michigan State Spartans Odds

With the new-look Big Ten and its 18 teams, Penn State didn’t play Michigan State last season for the first time in over a decade. The Nittany Lions lead the series 19-18-1 and they have won each of the last two meetings. Penn State has outscored MSU 77-16 in those two games.

The Spartans went 5-7 and 3-6 in the Big Ten in the first season under new head coach Jonathan Smith. The offense was awful, ranking in the bottom 25 of the nation in a number of categories like scoring (19.3 ppg). As a result, Michigan State went 4-8 ATS and failed to cover the spread in each of their final five games of the season.

Penn State went 13-3, played for the Big Ten title, and won two playoff games last season. The Nittany Lions were a top 10 defense and the offense averaged over 33 points per game. PSU was a double-digit favorite nine times last season. They wound up 8-8 ATS.

Penn State Nittany Lions @ Michigan State Spartans Predictions

Penn State returns one of the best quarterbacks in the country in Drew Allar. Plus, running backs Kaytron Allen and Nick Singleton, who each had 1,000 rushing yards last year, both chose to stay at PSU instead of opting for the NFL. That gives the Penn State offense seven returning starters.

The defense returns five starters and gets a new defensive coordinator in former Ohio State DC Jim Knowles. For those that may not know, Ohio State led the nation in scoring defense last year, allowing opponents just 12.9 points per game.

Until MSU QB Aidan Chiles and the Spartans offense proves it can keep up with the likes of Penn State, they will be a strong fade team. This could likely be another double-digit spread for the Nittany Lions when the line is released. Penn State will have another trip to the Big Ten title game on the line.

Bet: Penn State Nittany Lions (NA)

Notre Dame Fighting Irish @ Pittsburgh Panthers Odds

At the end of October last season, Pitt was 7-0. They would not win another game. The Panthers did not play Notre Dame last season. The two teams have played four times since 2015. The Fighting Irish have won all four games and won them by an average of 27.5 points. Ouch.

As has been the case in this rivalry for the past decade-plus, the Irish should be a pretty heavy favorite once the line comes out for this game. Remember, head coach Marcus Freeman and Notre Dame played for a national championship last season. The Irish played 16 games last year. They were favored in all but two – their season opener and the national title game.

Notre Dame leads this series 50-21-1 and, as mentioned, has won the last four meetings. Pitt’s last win came in 2013 and was at home in Pittsburgh. The Panthers last two wins both came in Pittsburgh (2009 was the other).

Notre Dame Fighting Irish @ Pittsburgh Panthers Predictions

The Irish are once again among the preseason top 10 teams in the country. Most experts projet Freeman’s team to be selected to the College Football Playoff once again. Their leading rusher, Jeremiyah Love is back as well as five other offensive starters. New QB C.J. Carr should be comfortable in the offense by this point in the season.

Notre Dame was one of the few teams that was among the top 15 scoring defenses and top 15 scoring offenses. The Irish averaged 36.1 points per game (12th) while the defense held opponents to 15.5 per game (4th).

Pitt came nowhere close to either number, though they did finish 32nd nationally in scoring (32.9 ppg). The defense will have to be much better in 2025. The Panthers gave up over 28 points and nearly 400 yards per game last season. They do return seven starters, including LB Kyle Louis, who finished third in the voting for Conference Player of the Year.

Still, the Panthers will find it hard to match the production of the Irish on either side of the ball, regardless of where the game is being played.

Bet: Notre Dame Fighting Irish (NA)

Utah Utes @ Baylor Bears Odds

For the first time in what seems like a decade, Utah and Utes fans will no longer be talking about Cam Rising as the team’s quarterback. After seven seasons, injuries finally caught up with the former Utah star and he retired from the game.

The Utes got former New Mexico dual-threat star Devon Dampier in the transfer portal. He is a similar quarterback to Rising. The Utes also have three offensive line starters back as well as TE Dallen Bentley. Head coach Kyle Whittingham’s teams are always built around a sound running and defense. Five starters return to a Utes defense that ranked in the top 30 in both scoring defense (20.7, 25th) and total defense (329.7, 29th).

Baylor is among the top five favorites to win the Big 12. They return one of the nation’s best quarterbacks in Sawyer Robertson. He didn’t start the first two games of the season, but still threw for over 3,000 yards and wound in 14th in the nation in passing efficiency. He has two starting receivers back and four of the five members of the offensive line.

With Utah new to the Big 12 after a stint in the Pac-12, these two teams have only met twice. Utah has won both games, including last year’s 23-12 win in Salt Lake City. It was a Week 2 game last year and the Utes were favored by 14.5. They did not cover the spread.

Utah Utes @ Baylor Bears Predictions

Utah will have a new look on offense. How well Dampier comes on and runs the offense will determine a lot about how the Utes season goes. The defense should be okay, but slowing down a Baylor offense that was 19th nationally in both points scored (34.4) and yards gained (440.1) is not going to be easy, especially with the Bears playing at home.

This late in the season, this will be a crucial Big 12 game too. The winner may still have a shot at the conference championship game. The winner may then also be part of the playoff discussion. Baylor was 5-1 last season and head coach Dave Aranda’s defense should be much improved in 2025.

Bet: Baylor Bears (NA)

Best College Football Week 12 Bets

Here are our favorite College Football bets for Week 12:

• Texas A&M Aggies to Win
• Penn State Nittany Lions to Win
• Notre Dame Fighting Irish to Win
• Baylor Bears to Win

We have a good blend of teams making the list of our best bets for Week 12 of the College Football season. However, we still need to be patient until the sportsbooks release the early lines for these matchups. Once available, this list of the best College Football Week 12 bets could change due to the value presented. Additionally, we’ll also discuss which of these bets will make our selection for a College Football parlay of the week.