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The Bills won in Week 1 and the Chargers lost. Here is where this game stands before Week 2 is played.
The game
The Chargers visit the Bills on Sunday 27 September at 1:00 PM ET. The game is in Orchard Park. It is a conference game, AFC West against AFC East.
The Bills finished 2025 at 12-5 and the Chargers at 11-6. They did not play each other in 2025.
Week 1
The Chargers lost to the Cardinals 26-14 at home, failing to cover as a 9-point favourite. The Bills beat the Texans 36-31 on the road, covering as a 1-point favourite.
That leaves the Chargers at 0-1 and the Bills at 1-0. Both play again in Week 2 before this game.
The early line
The early line has the Bills by 4, the median of 7 books, which range from 3.5 to 4.5. The total is 49.5, from 49.5 to 50.5 across books.
With the bookmaker margin removed, the moneyline makes the Bills 65.9% to win. These are early prices, read on 17 September 2026 at 06:14 UTC, and Week 2 will move them.
Los Angeles Chargers at Buffalo Bills, Sunday 27 September 2026, 1:00 PM ET. Prices: US sportsbooks via Nucleus, read 17 September 2026, 06:14 UTC. 2025 results: Nucleus, checked game by game against ESPN. Every Week 3 game: NFL Week 3 odds and predictions.
