The 2025 College Football season continues with an explosive Week 6. Week 5 gave us four matchups of ranked opponents and answered some early questions for bettors. This week, most of the Top 25 is in action, with two matchups of ranked opponents.

A not-so-surprising Vanderbilt is ranked No. 16 after starting the 2025 season 5-0. The Commodores will travel to No. 10 Alabama, who lost at Vandy last season. The other matchup of ranked opponents features No. 3 Miami at No. 18 Florida State.

The CFB Championship picture is starting to come into focus. We saw Penn State suffer yet another loss to a highly ranked opponent, losing to Oregon 30-24 in overtime.  Georgia lost once again to Alabama in another tight game, but both the Bulldogs and Nittany Lions are still very much alive in the playoff race.

It’s anyone’s guess who will ultimately square off in the 2025-26 College Football Playoffs, but Week 6 offers another chance for everyone to prove themselves.

With the College Football week 6 odds out at most online sportsbooks, let’s dive into our top picks and predictions to help you win some bets.

College Football Week 6 Schedule 

College Football Week 6 Odds 

Keep an eye on the latest College Football odds from the top online betting sites and monitor how the lines change throughout the week.

The most compelling matchup among Top 25 teams this week is easily the clash between No. 3 Miami and No. 18 Florida State. This rivalry once again means something, though the Seminoles fell victim to the upset last week at Virginia. The Hurricanes are 4.5-point road favorites.

Another big matchup featuring another Sunshine State team is the Texas-Florida game on Saturday afternoon. The Gators are now 6.5-point home underdogs after opening at +8.5. Florida head coach Billy Napier has been on the hot seat all season and the Gators schedule doesn’t help. 

Oklahoma lost its quarterback, John Mateer, to a hand injury, but that hasn’t prevented the books from installing the Sooners as 45.5-point favorites against Kent State on Saturday. Nothing comes close to that number this week. South Florida is favored by 26.5 points over Charlotte on Friday night.

The biggest total on the board comes from another Week 6 marquee game – Boise State at Notre Dame. The Irish have been putting up points by the bunches lately, scoring 56 points in each of their last two games. The total for this week is set at 65.5, the highest on the board.

Colorado State and San Diego State meet in each team’s first Mountain West conference game. The clash has the lowest total on the betting board at 39.5.

Our experts will run through the best games for Week 6 and offer preferred picks and predictions. If you want even more advice before placing your week 6 CFB bets, though, be sure to check out what the top sports betting handicappers have to offer.

Win your NCAAF Bets
With The Industry’s Best

Handicapping Membership

Get Free Trial

College Football Week 6 Predictions

Let’s take a look at the featured College Football Week 6 games and make our NCAAF Picks for each game. 

West Virginia Mountaineers @ BYU Cougars Odds

The West Virginia Mountaineers will visit the BYU Cougars on Friday night, giving fans just the third ever meeting between these two programs. West Virginia holds a 2-0 series advantage to this point, having won the most recent meeting in 2023.

West Virginia Mountaineers @ BYU Cougars Predictions

This season, West Virginia has had trouble scoring. With a 67% completion percentage, quarterback Nicco Marchiol has 720 yards, two touchdowns, and two interceptions. WR Cam Vaughn leads the team with two touchdowns and 277 yards.

So far, the defense has been on the field far too frequently. Safety Darrian Lewis has two interceptions, and Fred Perry leads with 33 tackles. The Mountaineers have given up 89 points in their last two games against Kansas and Utah, despite Chase Wilson’s three sacks. However, the offense’s excessive number of three-and-outs is largely to blame for that.

Both sides of the line of scrimmage have seen success for BYU. Bear Bachmeier, the quarterback, has six touchdowns, 697 yards, and no interceptions. LJ Martin leads BYU in rushing with 400 yards and one touchdown.

The front seven of the BYU defense has played well. Jack Kelly, a linebacker, has 19 total tackles and four sacks. BYU’s defense is stronger and their passing attack is superior. BYU has kept its last three opponents under 22 points, and West Virginia has had trouble moving the ball against elite opponents. The Cougars should remain undefeated at home.

Bet: ML pass, BYU -19.5 (-110), Over 47.5 (-115)

Kentucky Wildcats @ Georgia Bulldogs Odds

The Kentucky Wildcats have endured a rough history against the Georgia Bulldogs, and they’ll be looking up at a 64-12-2 deficit as they head into Week 6 at Sanford Stadium.

Georgia has obviously dominated the series, but it’s worth noting that they won by just one point (13-12) when these two sides met in 2024. In fact, the Wildcats kept it close (16-6) in 2022, although their 2023 win (a 51-13 Georgia victory) may be closer to the expectation for this showdown.

Kentucky Wildcats @ Georgia Bulldogs Predictions

While it’s true that the Kentucky Wildcats have previously given the Georgia Bulldogs some difficult games, those encounters haven’t happened in Athens.

That 51–13 Georgia win mentioned above came between the hedges at Sanford Stadium where Georgia has beaten Kentucky by at least 17 points in six consecutive visits. Over that stretch, the Dawgs have won five times by a margin of at least three touchdowns, with an average victory margin of 28.5 points.

Now, you have a Georgia team coming off a heartbreaking defeat to Alabama playing a Kentucky team that is among the worst at throwing the ball in college football. That is going to make this a difficult trip for the Wildcats.

Although the Wildcats have already changed quarterbacks, it hasn’t really made a difference. Cutter Boley was under constant pressure and unsure of who to throw to, which led to three turnovers in the loss to South Carolina. He was shaken by the hostile environment, and he will be even more shaken by this Georgia defense.

Even Alabama found it difficult against Georgia. The Bulldogs are ranked in the top ten for both EPA/rush and explosive run rate. They allow just 2.5 line yards and 0.6 second-level yards per rush.

Gunner Stockton has done well managing games for Georgia. Kentucky has allowed far too many explosive pass plays, and is ranked 73rd in pass success rate and 78th in EPA/pass. Five of the previous six home games have been won by the Dawgs by a margin of at least three touchdowns.

Bet: ML pass, Georgia -20.5 (-110), Under 48.5 (-110)

Clemson Tigers @ North Carolina Tar Heels Odds

The Clemson Tigers will take on the North Carolina Tar Heels on the road this week in what will be the 60th battle ever between these ACC squads. Both teams are off to disappointing starts in 2025.

Despite the rich history, these two teams last met in 2023. Clemson won that game by 11, and has won six straight in the series.

Clemson Tigers @ North Carolina Tar Heels Predictions

Cade Klubnik, the starting quarterback for Clemson, has thrown for 996 yards, six touchdowns, and four interceptions. Bryant Wesco Jr. has 24 receptions for 389 yards and five touchdowns to lead all Clemson receivers. Adam Randall gives the offense balance with 338 rushing yards and three touchdowns on the ground,

The Tigers have a solid front-line defense. Linebacker Wade Woodaz leads the team with 35 tackles, and Will Heldt has three sacks. The front seven can shut down opponents, but Clemson has struggled in close games against Syracuse and Georgia Tech. Finding consistent drives and reducing turnovers are essential for Clemson to get back on track.

UNC QB Gio Lopez has 430 passing yards, three touchdowns, and three interceptions. Jordan Shipp leads the receiving corps with 193 yards and two touchdowns on 13 catches. RB Demon June leads the Tar Heels ground attack with 250 yards rushing and an average of 7.6 yards per carry.

Clemson has the more established offensive weapons. Clemson’s defensive front and secondary should make the difference. Lopez will struggle against the Tigers defensive pressure.

Bet: ML pass, Clemson -14 (-112), Over 45.5 (-110)

Syracuse Orange @ SMU Mustangs Odds

There is not a rich history between the Syracuse Orange and the SMU Mustangs. The two sides have met just one time throughout the history of college football. Syracuse won that game way back in 1932.

The two teams meet for the first time since and will play each other more often now as both are members of the ACC.

Syracuse Orange @ SMU Mustangs Predictions

Syracuse has had mixed results so far this season, with three victories and two losses overall. Things aren’t looking good for the Orange as QB Steve Angeli went down with a season-ending injury in Week 4. Last week without Angeli, the Orange managed just three points and lost to Duke by 35 points at home.

In their two losses, the Orange averaged just 14.5 points per game. The defense has allowed 29 points per game, 41.5 in the two losses. That is going to be an issue against an SMU offense that can put up points.

SMU is scoring 34.7 points per game this season. The Mustangs are led by QB  Kevin Jennings who has 1126 passing yards and nine touchdowns. TJ Harden leads the team in rushing with 57 carries for 309 yards and five touchdowns. Romello Brinson (19 rec., 365 yds., 3 TDs) is the team’s leading receiver.

Without Angeli, the Syracuse offense will continue to struggle. Playing on the road, the Orange face a formidable opponent in front of their home crowd. This could get out of hand like it did last week in Syracuse’s 35-3 loss to Duke.

Bet: ML pass, SMU -16.5 (-110), Over 58.5 (-108)

Vanderbilt Commodores @ Alabama Crimson Tide Odds

Vanderbilt was among the worst teams in the SEC in 2024 with a 3-5 record, but the Commodores did pull one of the season’s biggest upsets last year when they beat Alabama at home, 40-35. You can bet the Crimson Tide is looking for some revenge on their home turf this year.

Alabama owns this series with a 60-20-4 record. Prior to last season, Vanderbilt’s last win over the Tide came in 1984. That game was played in Tuscaloosa, the site of this Week 6 clash.

Vanderbilt Commodores @ Alabama Crimson Tide Predictions

With an average of 49 points per game, the 16th-ranked Commodores (5-0) are fifth in the SEC in terms of scoring offense. Vanderbilt defeated Utah State 55-35 at home on Saturday after scoring 24 points in the last six minutes of the first half.

Halfway through the second quarter, Vanderbilt was behind, but quarterback Diego Pavia’s six-yard touchdown run tied the score at 14-14. Pavia set a school record with five passing touchdowns and threw for 321 yards.

After losing to Florida State in the first game of the season, the Alabama Crimson Tide have won three in a row. Arguably one of the top five most talented teams in the nation, the 10th-ranked Crimson Tide (3-1) give up 16.5 points per game. Last week, Alabama defeated fifth-ranked Georgia 24–21 on the road while having the ball for more than 35 minutes.

With touchdown passes from Ty Simpson to Isaiah Horton and Germie Bernard, Alabama jumped out to a 14-0 lead. Horton finished with a game-high 65 receiving yards for the Crimson Tide, who converted 13-of-19 third-down attempts, and Simpson entered the Heisman discussion with 276 passing yards.

Vanderbilt QB Diego Pavia has totally transformed the program’s image. Alabama will undoubtedly be focused after losing to Vanderbilt last season. Both offenses can score, but this one feels like an Alabama spot.

Bet: ML pass, Vanderbilt +10.5 (-108), Over 57.5 (-108)

Texas Longhorns @ Florida Gators Odds

Arch Manning leads his Texas Longhorns into the swamp to battle the Florida Gators this week. Texas coasted to a big 49-17 win when these two teams met last year, but this is shockingly just the fifth meeting ever between these two programs with rich football histories.

Prior to last season, the two sides last met way back in 1940. Texas owns a commanding 3-0-1 series advantage. With the point spread inside of a touchdown for this game, it indicates this one could be closer than what we saw a year ago.

Texas Longhorns @ Florida Gators Predictions

Both defenses are elite entering this week’s game. Texas (3-1) lost its season opener to Ohio State, 14-7. Texas defeated Sam Houston 55-0 at home last time out, limiting the Bearkats to 113 yards from scrimmage.

The Longhorns are second nationally allowing just 7.7 points per game. They are fourth against the run (59.7 ypg) and 16th against the pass (152.5 ypg). Offensively, Texas is led by QB Arch Manning, who had 309 passing yards and three touchdowns in the win over Sam Houston.

Head coach Billy Napier is once again under fire after the Florida Gators have only scored 33 points in their last three games. The Gators (1-3) rank dead last in the SEC in terms of total offense and have already lost two games against in-state opponents. Last Saturday, Florida lost badly to fourth-ranked Miami 26-7 on the road, managing just 141 yards on offense.

Florida QB DJ Lagway is struggling. He threw for just 61 yards in the loss to Miami. The week prior, Lagway tossed five interceptions in a loss to LSU. Lagway was banged up in the Miami game but is expected to play against Texas.

The Florida defense ranks in the top 35 in scoring, rushing, passing, and total defense. Beating the Gators at home won’t be an easy task.

Bet: Florida +205, Florida +6.5 (-108), Under 43.5 (-110)

Penn State Nittany Lions @ UCLA Bruins Odds

The Penn State Nittany Lions and UCLA Bruins have had a short but competitive history. The Bruins hold a slim 4-3 series advantage, but this will be just the eighth meeting ever.

The most recent meeting was a lopsided 27-11 win for Penn State in 2024, but this season’s showdown will be just the second time these two sides have battled since 1968.

Penn State Nittany Lions @ UCLA Bruins Predictions

Penn State, a preseason favorite to win the Big Ten and the college football national championship, went to double overtime against visiting Oregon last Saturday and lost 30–24. Still, the Nittany Lions can achieve all of their goals, including winning the Big Ten.

The defense is once again elite, allowing just 11.8 points per game (10th in the nation).  Penn State fell behind 17-3 last week but rallied to tie the game thanks to two touchdown receptions from Devonte Ross. Kaytron Allen’s four-yard touchdown run in the first overtime gave the Nittany Lions a 24–17 lead. Penn State’s offense gained only 276 yards.

Tim Skipper was named the interim head coach of the UCLA Bruins, who are the only team without a win in the Big Ten Conference. The Bruins (0-4) score a pitiful 14.3 points per game and are last in the conference in terms of total offense. UCLA lost to Northwestern 17–14 on the road last week. How the Bruins offense will do anything against this Penn State defense is the big question. Tennessee transfer Nico Iamaleava also leads the Bruins in rushing with 204 yards and a touchdown. He’ll need some help if UCLA is going to compete on Saturday.

Bet: ML pass, UCLA +25.5 (-115), Under 49.5 (-105)

Boise State Broncos @ Notre Dame Fighting Irish Odds

The Boise State Broncos (3-1) travel to South Bend to take on Notre Dame in the first-ever meeting between the two football programs. Boise State is a big underdog despite having the better record.

One look at the schedule tells you why the Broncos are big underdogs. Boise State has wins over FCS Eastern Washington, Air Force, and Appalachian State. The Broncos scored at least 47 points in all three of those wins.

Boise State Broncos @ Notre Dame Fighting Irish Predictions

When handicapping the total, it’s difficult to look in any other direction because Notre Dame has cashed the Over in each of its four games. The Irish have scored 56 points in each of the last two games. As mentioned, Boise State scored 47-plus in each of its last three games.

The nation’s best skill players, aside from Jeremiah Smith, are Jeremiyah Love (490 scrimmage yards, 8 touchdowns), and Jadarian Price (308 scrimmage yards, 7 touchdowns). These two are among the top five running backs in the country. If the Irish hadn’t allowed Texas A&M to score a touchdown in the final seconds on a fourth down, quarterback CJ Carr (10.5 yards per attempt) would be receiving more Heisman love.

Boise State’s defense is nothing special. South Florida and Air Force gained 7.0 and 6.9 yards per play, respectively. In their two most difficult tests of the season, the Broncos struggled defensively, which is concerning when facing an Irish offense that has scored 40 points or more in three straight games.

Irish head coach Marcus Freeman knows that for his team to get into the College Football Playoff they cannot afford another loss. Plus, they’ll need to convince the committee that they belong. That means plenty of big wins, including this one on Saturday.

Bet: ML pass, Notre Dame -19.5 (-110), Over 64.5 (-115)

Minnesota Golden Gophers @ Ohio State Buckeyes Odds

The Minnesota Golden Gophers and Ohio State Buckeyes give us a fun Big 10 battle in Week 6, but the “fun” part all depends on which side you’re rooting for. The defending national champion Buckeyes are large favorites once again after cruising past Minnesota (37-3) last year. Ohio State has dominated the series. The Buckeyes lead 47-7 all-time.

Minnesota last stole a win against the Buckeyes way back in 2000. The Golden Gophers are off to a 3-1 start this season. All three wins were at home while Minnesota’s loss came on the road at California.

Minnesota Golden Gophers @ Ohio State Buckeyes Predictions

Minnesota QB Drake Lindsey has completed 66% of his passes and thrown for 958 yards, seven touchdowns, and two interceptions. Fame Ijeboi leads the running game with 173 yards and one touchdown, while Javon Tracy leads the receivers with 204 yards and two scores. In three of their last four games, the Gophers have scored 30 points or more.

The Minnesota defense is still its strength. The Gophers rank fifth in the nation against the run (65.5 ypg), 23rd against the pass (164.5 ypg), and 26th in scoring defense allowing 16.2 points per game. Minnesota’s defense was so good last year that defensive coordinator Corey Hetherman was hired away by No. 3 Miami.

Ohio State QB Julian Sayin has completed almost 79% of his passes and has amassed 987 passing yards, 10 touchdowns, and three interceptions. With 396 yards and four touchdowns, Jeremiah Smith is Sayin’s go-to receiver and Bo Jackson, with 297 yards and a touchdown, adds balance in the run game.

Ohio State’s defense is even better than Minnesota’s. The Buckeyes rank No. 1 in the nation in scoring defense allowing just 5.5 points per game. They have held three of four opponents to single digits.

There is no question the Buckeyes are more talented on offense. They average over 36 points per game and Smith is probably the best receiver in the country. Both defenses will play well, but it’s tough seeing Minnesota score much against this Ohio State defense.

Bet: ML pass, Ohio State -23.5, Over 44.5 (-110)

Miami Hurricanes @ Florida State Seminoles Odds

The Miami Hurricanes and Florida State Seminoles will meet for the 70th time in Week 6. The two have waged war in the ACC for quite some time, and their overall series has been extremely competitive.

This time around, both teams are ranked in the most recent AP Top 25. Miami is No. 3 while FSU comes in at No. 18. The Hurricanes do hold the upper hand (36-33) in the series at the moment. They also won last year’s meeting (36-14) pretty easily. However, Florida State won the previous three meetings and the Hurricanes don’t have star quarterback Cam Ward to bail them out anymore.

Miami Hurricanes @ Florida State Seminoles Predictions

Miami averages 36.7 points per game this season. The defense has improved drastically under Hetherman, who we mentioned in the Minnesota-Ohio State preview. The ‘Canes give up just 11.5 points per game.

On the offensive side of the ball, QB Carson Beck leads the Miami offense with 82 completions, 932 yards, and seven touchdowns. The leading ball carrier, Mark Fletcher Jr., has 66 carries for 388 yards and five touchdowns. Malachi Torey leads all receivers with 268 yards and one touchdown on 22 grabs while CJ Daniels has contributed 18 receptions for 191 yards and three touchdowns.

Florida State averages53 points per game, best in the nation. Florida State has struggled some on defense, giving up 19 points per game. The Seminoles gave up 46 points in their loss to Virginia last week.

Tommy Castellanos leads the Florida State offense with 848 passing yards and four touchdowns. Gavin Sawchuk leads the Seminoles in rushing with 234 yards and six touchdowns on 42 carries. Duce Robinson is the leading receiver with 17 receptions, 346 yards, and three touchdowns.

This should be a classic Miami-FSU battle, but the Hurricanes are clearly the best team in the ACC. If there is one team that can slow down the Seminoles offense, it’s Miami.

Bet: Miami -185, Miami -4.5 (-108), Over 54.5 (-108)

Best College Football Week 6 Bets

Each week throughout the 2025 NCAAF season, the ScoresandStats college football experts examine the top College Football teams and put their heads together and come up with their best bets. Of the 7 to 10 games previewed each week, our handicappers will pick two or three that they like the best.

Here are our favorite bets this week:

• Kentucky @ Georgia -20.5 (-110)
• Syracuse @ SMU -16.5 (-110)
• Texas @ Florida Under 43.5 (-110)

You don’t want to be Kentucky facing Georgia after losing to Alabama. Last year, the Bulldogs dropped a tough game to the Crimson Tide and came back and smoked Auburn 31-13. The year before, Georgia lost to the Tide in the SEC title game. The Bulldogs beat Florida State in their bowl game … 63-3!

Kentucky’s offense is awful and you can bet Kirby Smart will dial up the heat on Saturday. Georgia has beaten Kentucky at home by double-digits for so long it hurts.

Speaking of hurting, Syracuse travels to SMU, which is also coming off a loss. The Mustangs lost their second game of the season to TCU. It was a non-conference game, but SMU needs to prove it belongs in the playoff discussion again this season. That means there is no room for error since SMU has two losses.

Syracuse lost starting QB Steve Angeli for the season to an Achilles injury. Without him last week against Duke, the Orange offense struggled. On the road this week, they’ll continue to have some issues.

Finally, what’s not to love about a game total that screams Under? When the board opened, this total was actually as high as 53.5. Now, it’s all the way down to 43.5. These two defenses are the reason why. Both are among the nation’s best and will make it difficult for the opponent to score.

If you want to place all three of these Week 5 picks into an NCAAF parlay, then you would win a staggering $596 on a $100 wager. That’s a 6x on your investment. If you want more parlay action, check out our best College Football parlays of the week.