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With that said, we do have a handful of NFL picks for Week 10 that we are really high on. Most of these picks are road teams but a few of these lines seem to have missed the mark. So, that’s where we swoop in and try to maximize the perceived betting value.
The defending Super Bowl champions have made our list this week; along with a few other teams looking to pick up much-needed wins or those that we believe will keep the game close.
NFL Week 10 Underdog Picks
| Team | Spread | Moneyline |
|---|---|---|
| Philadelphia Eagles | +1 (+104) | +110 |
| Atlanta Falcons | +6.5 (-110) | +249 |
| New York Giants | +4.5 (-110) | +183 |
| New York Jets | +2.5 (-110) | +115 |
Last week, we went 3-1 in our Underdog picks. If it weren’t for the Saints getting blown out, then we would’ve had a perfect week of Underdog picks and a monster parlay hit.
This week, all of our underdog NFL teams have appealing spreads that we’re targeting. This is a more sensible approach then taking a big swing at larger moneylines.
Of course, I am just one voice here at Scores and Stats. We have a bunch of terrific NFL betting experts, as well as elite offerings. You can test it all out for free via our sports handicapping service.
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NFL Underdog Picks For Week 10
Check out our best NFL underdogs this week:
Philadelphia Eagles +1 (+104) vs. Green Bay Packers
The Week 10 Monday Night Football game is going to be a great one as the Green Bay Packers host the Philadelphia Eagles.
The Packers are coming off their second loss of the season as the Panthers rolled into town and nipped them by a field goal. The Eagles are coming off their bye week and enter with a two-game winning streak.
Philly is 4-1 SU and 4-1 ATS in their last five games against the Packers. Furthermore, the Eagles are 9-0 SU in their last nine NFC North games, 9-0 SU in their last nine November games, and 8-2 ATS in their last 10 road games. The Packers are 2-6 ATS in their last eight NFC games and 1-5 ATS in their last six overall games.
Last weekend, Rico Dowdle ran for 130 yards on the Packers Top 5 rush defense. I think Saquon Barkley will have a big game this week. Additionally, watch for Jalen Hurts to extend plays with his legs and for Philly to rely on their elite passing weapons in Brown, Smith and Goedert.
Atlanta Falcons +6.5 (-110) vs. Indianapolis Colts
Both of the Falcons and Colts come into this NFL International game having lost in Week 9. For Indy, it was a surprising loss to the Steelers as the Colts turned the ball over six times. The Falcons lost by one point to the Patriots in Drake London’s best game of his career.
This week, these two teams will head to Berlin, Germany, for the NFL’s sixth International game. So, neither team will have that home advantage.
Indy has dominated the series in recent years versus the Falcons. The Colts are 15-3 SU in their last 18 head-to-head matchups, while going 6-2 ATS in their last eight meetings.
With that said, I do believe the Falcons will play this game tough and keep it within one score. Indy is 1-4 ATS in their last five November games and 0-5 ATS in their last five NFC games.
Furthermore, the Falcons have the no.1 pass defense (158.1 ypg), which should nullify Indy’s no.2 pass offense (257.8 ypg). Additionally, Atlanta has a Top 5 defense according to sack rate. We saw what Pittsburgh’s pass rush did last weekend against the Colts, which ended up being the difference in the game.
In a battle of two elite running backs Bijan Robinson (Atl) and Jonathan Taylor (Ind), this game is going to be a close one for NFL bettors and a boon for fantasy football GMs. Take Atlanta to keep the game within a touchdown.
New York Giants +4.5 (-110) vs. Chicago Bears
Although the New York Giants have lost three games in a row, they have been competitive in all of them. New York is 0-5 in road games this year, so I don’t see them winning this matchup. However, Chicago has a dreadful defense which means that the Giants should be able to keep this game within four points.
New York is 4-1 ATS in their last five games against the Bears. Even better, the Giants are 7-1 ATS in their last eight games at Chicago. The Bears are 2-6 SU in their last eight home games. So, this matchup is setting up for a Giants win against the spread.
The Bears give up the 4th most points at 28.4 ppg. That’s slightly worse than New York’s 27.7 ppg which is the 5th most. Both teams give up a ton of yards. Chicago will find success on the ground against the Giants who have the 2nd worst run defense. However, I feel that New York’s pass rush will cause some problems for Caleb Williams.
The Bears have given up 36 ppg over the last two weeks. That bodes well for a New York team trying to claw their way back to respectability. Take the Giants to cover the spread.
Cleveland Browns vs. New York Jets +2.5 (-110)
This is a battle of two of the NFL’s worst teams in 2025. Combined, they’re 3-13 on the year. Both teams are also coming off a bye which means neither will have the advantage. Fortunately for New York, they should get their key playmakers back in Garrett Wilson.
Sure, the Jets’ defense lost two key players via trades this week but this unit was atrocious with them. So, it’s not going to be a huge loss for this season’s team.
The Jets are 7-3 SU and 7-3 ATS in their last 10 games against the Browns. Additionally, Cleveland is 0-9 ATS in their last nine road games, 1-4 ATS in their last five overall games.
New York isn’t much better according to the betting trends but they will be at home and they are healthier. Plus, teams that usually make some extreme trades in the middle of the season have a way of bouncing back following those moves.
The Browns only score 15.8 ppg, so that bodes well for a Jets offense that averages 21 ppg. Additionally, the Browns have one of the worst offenses in the league. The Jets have the no.3 running game and should be able to find some success on the ground this week with Hall, Davis and Fields.
I like the Jets to prove something this week as they play for their coach and their pride. Take New York to cover the points at home.
NFL Underdog Parlay
- Philadelphia Eagles +1 (+104)
- Atlanta Falcons +6.5 (-110)
- New York Giants +4.5 (-110)
- New York Jets +2.5 (-110)
Underdog parlays are risky bets, but this one has some real juice that we think has a serious shot at hitting. If you lay $100 on this four-leg parlay at the top online betting sites, then you would win $1319. That’s a 13x on your initial investment.
I don’t know about you, but a flier on this parlay seems like a great addition to your Week 10 NFL card. Also, if you want more exciting parlay action, then check out our best NFL parlays of the week and our best College Football parlays of the week.
Best NFL Underdog Picks For Week 10
The riskiest selection of our four NFL Week 10 Underdog picks is the Jets to cover 2.5 points. With that said, our favorite Underdog pick for Week 10 is the Eagles to cover and win the game. Philadelphia is coming off a bye week and well rested. NFL teams are 10-4 SU following a Bye.
The Eagles have the defense to make Jordan Love’s night a tough one. Additionally, they can beat Green Bay via the run or pass. And, we saw what Carolina just did to the Packers in Week 9.
