Florida at Missouri Best Pick, Prediction and Odds

No. 21 Florida visits No. 19 Missouri on Saturday 3 October, at Memorial Stadium in Columbia, with kickoff at 3:30 PM ET. Florida opened as a 2.5-point favorite. Rankings are from the AP poll for week 4.

This is the early page for the game: what is already known. Our full prediction, with the call and the numbers behind it, goes up on this page before kickoff.

The two teams in 2026, through 23 September

Florida is 3-0 this season, 1-0 in the Southeastern Conference. Most recently it beat Auburn 44-39 on the road on 19 September. It has scored 54.0 points a game and allowed 21.0.

Missouri is 3-0 this season. Most recently it beat Troy 27-17 at home on 19 September. It has scored 39.7 points a game and allowed 17.3.

Last season

Florida went 4-8 in 2025, scoring 21.6 points a game and allowing 24.0.

Missouri went 8-5 in 2025, scoring 30.2 points a game and allowing 18.9. Its season ended with a loss against Virginia, 13-7.

The early line

At DraftKings, read 24 September 2026, Missouri is +2.5. The total is 53.5. The moneylines price Missouri to win 45.7% of the time, with the margin removed.

Lines move through the week. The full prediction reads them again on the day it goes up.

The teams

The Florida Gators and Missouri Tigers team pages hold both schedules and last season’s results. Every game this week is on our college football predictions page.

Florida at Missouri, Saturday 3 October, 3:30 PM ET, at Memorial Stadium in Columbia. Results: ESPN, read 24 September 2026. Line: DraftKings via ESPN, read 2026-09-24 05:06 UTC. Rankings: 2026 NCAA Football Rankings – AP Poll Week 4.