Washington at USC Best Pick, Prediction and Odds

Washington visits No. 12 USC on Saturday 3 October, at Los Angeles Memorial Coliseum, with kickoff at 7:30 PM ET. USC opened as a 10-point favorite. Rankings are from the AP poll for week 4.

This is the early page for the game: what is already known. Our full prediction, with the call and the numbers behind it, goes up on this page before kickoff.

The two teams in 2026, through 23 September

Washington is 3-0 this season. Most recently it beat Eastern Washington 48-16 at home on 19 September. It has scored 29.3 points a game and allowed 13.3.

USC is 4-0 this season, 1-0 in the Big Ten Conference. Most recently it beat Rutgers 42-35 on the road on 19 September. It has scored 43.0 points a game and allowed 22.8.

Last season

Washington went 9-4 in 2025, scoring 34.1 points a game and allowing 18.7. Its season ended with a win against Boise State, 38-10.

USC went 9-4 in 2025, scoring 35.8 points a game and allowing 23.0. Its season ended with a loss against TCU, 30-27.

The early line

At DraftKings, read 24 September 2026, USC is -10. The total is 57.5. The moneylines price USC to win 75.1% of the time, with the margin removed.

Lines move through the week. The full prediction reads them again on the day it goes up.

The teams

The Washington Huskies and USC Trojans team pages hold both schedules and last season’s results. Every game this week is on our college football predictions page.

Washington at USC, Saturday 3 October, 7:30 PM ET, at Los Angeles Memorial Coliseum. Results: ESPN, read 24 September 2026. Line: DraftKings via ESPN, read 2026-09-24 05:07 UTC. Rankings: 2026 NCAA Football Rankings – AP Poll Week 4.