The holidays are approaching and College Football fans are loving the mid-week college football action this time of year. The MAC continues its play on Tuesday night to kick the week off.

Week 11 was the first dose of MAC-tion in the 2025 season and it didn’t disappoint. Kent State and Akron and Ohio and Western Michigan get Week 12 started on Tuesday night. Three more MAC games are on the schedule for Wednesday night.

Week 12 continues the meat of the conference schedules and it’s loaded with SEC, Big Ten, Big 12, and ACC matchups that will all have significance in the conference races. We also get four quality ranked-vs.-ranked games.

This week, the following are matchups featuring ranked opponents:

• No. 10 Notre Dame @ No. 24 Pittsburgh
• No. 12 Oklahoma @ No. 4 Alabama
• No. 20 Iowa @ No. 19 USC
• No. 11 Texas @ No. 5 Georgia

The results of these games will most definitely have an impact on the 2025 College Football Playoffs. The second College Football Playoff rankings will be out this week. Ohio State and Indiana, both winners last week, should remain No. 1 and No. 2, respectively.

These final weeks of the regular season are super important. Teams with their eyes on a conference championship or a berth in the playoffs cannot afford an upset loss at this point in the season.

As we get into these final weeks of the regular season, be sure you are checking ScoresandStats on a daily basis from now until the college football national championship game. Our NCAAF experts will continue to provide inside analysis, free picks, game predictions, and more!

College Football Week 12 Schedule

College Football Week 12 Odds

Keep an eye on the latest College Football odds from the top online betting sites and monitor how the lines change throughout the week.

At this point in the season, we don’t expect to see many huge point spreads as teams are playing through their conference schedules. There are some heavy mismatches this week, though, mainly in the Big Ten.

No. 2 Indiana is a 29.5-point home favorite against a struggling Wisconsin, which actually pulled off an upset of Washington last week. The Hoosiers are not the biggest favorite of the week nor are they the biggest favorite in the Big Ten.

That honor belongs to No. 1 Ohio State. The Buckeyes will play host to UCLA. Ohio State is a 31.5-point favorite at the Horseshoe, but that is not the largest point spread in Week 12. That would be Tennessee, which is a 40.5-point favorite in a non-conference game against New Mexico State.

As far as totals, any time you have North Texas in the picture, there’s a good chance there is a high total associated with it. The Mean Green will play at a struggling UAB. The game total is 69.5. It is not the largest total on the board.

That would be in the Utah State-UNLV game. Both teams have offenses that are very capable of putting up points. On the other side of the ball, both teams leave a lot to be desired. That’s why the game total is 70.5!

The lowest total on the board is in the ACC. It’s an improving North Carolina playing at Wake Forest. Both teams, especially the Tar Heels, are playing outstanding defense. This should be a low-scoring, defensive battle. The total for this game is set at 39.5.

Make sure you check ScoresandStats top handicappers each week of the college football season. They can help you understand how to approach some of these big point spreads and game totals.

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College Football Week 12 Predictions

Let’s take a look at the featured College Football Week 12 games and make our NCAAF picks for each game.

Notre Dame Fighting Irish @ Pittsburgh Panthers Odds

Pitt did not start this season like 2024. At the end of October last season, Pitt was 7-0. They would not win another game. This year, they lost two straight games early in the season and have now won five straight heading into this meeting with No. 10 Notre Dame.

The two teams have played four times since 2015. The Fighting Irish have won all four games and won them by an average of 27.5 points.

As has been the case in this rivalry for the past decade-plus, the Irish are a fairly heavy favorite. Notre Dame leads this series 50-21-1 and, as mentioned, has won the last four meetings. Pitt’s last win came in 2013 and was at home in Pittsburgh. The Panthers last two wins both came in Pittsburgh (2009 was the other).

Notre Dame Fighting Irish @ Pittsburgh Panthers Predictions

The Irish started the 2025 season with two losses, both to ranked opponents. They have reeled off seven straight victories since. QB C.J. Carr is no longer an inexperienced redshirt freshman. He leads one of the nation’s best passing offenses. The Irish average 271.7 passing yards per game which ranks 26th in the nation.

Jeremiyah Love (988 yards, 13 TDs) and Jadarian Price (568, 9 TDs) form the best one-two rushing tandem in the nation. The Irish offensive line is considered to be one of the best in the country and Notre Dame is also 26th in the nation in rushing yards per game (194.4).

Do not discount the Pitt Panthers. Under head coach Pat Narduzzi, the Panthers are the No. 3 run defense in the country. However, they’ve won five straight games because of an offense that can put points on the board.

In their five consecutive victories, the Panthers have scored 30 or more points in all five and they’ve averaged 40 points per game in that span.

Mason Heintschel replaced starting QB Eli Holstein at the beginning of October. That change has led to the five straight wins for Pitt. Heintschel has thrown for 1,547 yards and 12 touchdowns. The Pitt passing offense ranks 11th in the nation, averaging 302.9 yards per game. Notre Dame will have its hands full trying to slow down the Panthers.

The Irish cannot afford another loss if they want to make the CFP, but Pitt is in a great spot here to pull off the upset. The Panthers might not get the outright win, but they should be able to keep this one close. Pitt is also 5-0 ATS in its last five games.

The total also indicates the Over is in play. The last two times these teams met the totals were 45.5 and 43.5. Now, we see the number roughly 10 points higher and the Over has cashed in four of the last six meetings between these two.

Bet: ML pass, Pittsburgh +11.5 (-108), Over 55.5 (-105)

South Carolina Gamecocks @ Texas A&M Aggies Odds

Texas A&M joined the SEC in 2012 and since then these two teams have played 11 times. The Aggies have won nine of those games, but they have beaten the Gamecocks every single time they have visited Kyle Field in College Station.

The Gamecocks won two of the last three meetings, including last year’s 44-20 blowout of the Aggies. Both of those South Carolina wins were in Columbia. The Gamecocks did go 3-1 on the road in the SEC last season but so far this season they are 0-3.

South Carolina has now lost four straight games, all to teams that were ranked in the AP Top 25 at the time of the game. Now, they face Texas A&M, the No. 3 team in the nation. The Gamecocks are 3-6 overall, which means they must win out to have a shot at a bowl game.

South Carolina Gamecocks @ Texas A&M Aggies Predictions

The Aggies offense led the SEC in scoring last year. This year’s version might be even better. QB Marcel Reed has thrown for 2,193 yards and 19 touchdowns. He also has six more scores on the ground. The Aggies average 37.8 points per game (12th in the nation) which is one reason why they are 4-1 ATS in their last five games. The Aggies outscore their opponents by an average of 14.9 points per game.

The defense is not a typical Mike Elko-coached defense, but the Aggies give up 22.9 points per game and they have one of the better pass defenses (189 ypg, 31st) in the FBS. South Carolina is not a very dynamic offense and they are one of the worst scoring units in college football, averaging 19.7 points per game (120th).

There’s no question Texas A&M wins this game, but with the Gamecocks still having a shot at a bowl game they are likely to give the Aggies their best game. Plus, head coach Shane Beamer needs to put on a good show to keep his job.

Bet: ML pass, South Carolina +18.5 (-108), Over 47.5 (-118)

Oklahoma Sooners @ Alabama Crimson Tide Odds

These are two of the most recognizable programs in college football. Between them, Oklahoma and Alabama claim 23 college football national championships. In the history of the game, these two programs have only met seven times.

Oklahoma holds a 4-2-1 advantage in the series. Last year was the first year that the two programs played as members of the SEC. The Sooners pulled off the 24-3 upset in Norman last year as a two-touchdown underdog. Now, we see the Crimson Tide laying 6.5 points.

Oklahoma Sooners @ Alabama Crimson Tide Odds

After an upset loss to Florida State to start the season, Alabama has run it back through a very tough schedule that includes eight straight wins, four of which have been against ranked opponents.

Oklahoma is coming off a huge win over Tennessee (33-27) in Knoxville. The Sooners have only played three true road games and they won and covered the spread in all three. It should be a great matchup as Alabama is 5-0 straight up and against the spread at home this season.

Sooners QB John Mateer has struggled over the last four games. Alabama has one of the best pass defenses (10th, 164.7 ypg) in the country. The Crimson Tide has more interceptions than touchdown passes allowed.

Oklahoma also has an outstanding defense. The Sooners are fourth in the nation against the run and seventh in scoring defense, allowing just 14.1 points per game. The pass defense is also sound and ranks No. 22 in the FBS. Alabama’s pass offense ranks 14th and QB Ty Simpson has been mentioned in the Heisman Trophy discussion.

This should be a battle of two of the best defenses in the nation. Seven of Oklahoma’s nine games have gone Under the total. Alabama averages almost 33 points per game, but they also have a top-15 scoring defense like Oklahoma. Five of Alabama’s last six games have gone Under the total.

Bet: Alabama -225, Alabama -6.5 (-108), Under 45.5 (-108)

Iowa Hawkeyes @ USC Trojans Odds

This is a big game this weekend as it pits two ranked Big Ten teams against one another. The 20th-ranked Hawkeyes travel west to face the 19th-ranked Trojans at the LA Memorial Coliseum.

These two programs have only played each other a total of 10 times. USC holds a 7-3 lead in the series. The two most recent meetings were actually in bowl games. In 2017 the teams met in the Orange Bowl. USC won the game 38-17.

The most recent meeting took place in 2019. Iowa recorded a 49-24 victory over the Trojans in the Holiday Bowl.

Iowa Hawkeyes @ USC Trojans Odds

Everyone seemingly forgot about the Iowa Hawkeyes. They are now 6-3 after a tough home loss to Oregon last week. The Hawkeyes defense kept them in the game, but Oregon kicked a late field goal to win 16-13.

Still, the Hawkeyes are a tough out in Big Ten play. They give up just 13.1 points per game (5th in the nation) and they rank in the top 25 against the run and the pass. USC boasts one of the nation’s best passing games. The Trojans average 303 passing yards per game (10th) led by QB Jayden Maiava, who has passed for 2.614 yards and 17 touchdowns.

The USC defense is better than most think. The Trojans have won three of their last four games. In those three wins, the defense allowed 17 points or less in all three games. The defense should have an easier time as Iowa is a ground reliant team and doesn’t throw the ball all that well. Iowa’s pass offense ranks 133rd out of 136 FBS teams.

Traveling west is also something Iowa will have to deal with. Other Big Ten teams that have traveled west and have not fared well. Michigan, Minnesota, Michigan State, and Northwestern all traveled to USC and lost. Penn State and Maryland traveled to UCLA and lost.

The one thing that will keep Iowa in this game is its defense and special teams. Watch out for Kaden Wetjen, Iowa’s speedy return man. He can change a game with one touch.

Bet: USC -238, Iowa +6.5 (-110), Under 49.5 (-110)

Utah Utes @ Baylor Bears Odds

These two teams have only played each other twice. Both of those games have come within the last two seasons. The Utes and Bears played last season and in 2023. The two will likely play more often now as both are members of the Big 12.

Utah has won both games in the series. In 2024, it was a 23-12 Utes victory as Utah scored the first 23 points of the game unanswered in the first half. Baylor added two field goals and a touchdown to set the final score.

Utah comes into the game at 7-2 and ranked No. 13 in the latest AP poll. The Utes have won three of four road games this season. The Bears have won three of five at home.

QB Devon Dampier leads the Utes offense. He has thrown for 1,588 yards and 15 touchdowns. He’s also rushed for 520 yards and five more scores. Wayshawn Parker is the Utes leading rusher with 607 yards.

The big difference in this game is the Utes defense. They rank eighth in the nation in points allowed per game (14.2). They are also sixth in pass defense, which happens to be the strength of the Utes offense.

Baylor QB Sawyer Robertson has thrown for 2,780 yards and 26 touchdowns in nine games. The offense can score. The Bears average 33.8 points per game. The problem is they give up 29.3 (100th) per game.

The game total is set much higher than last year, which indicates the Over is the play. As good as the Utah defense is, many forget that the Utah offense averages nearly 40 points per game.

Bet: ML pass, Utah -9.5 (-110), Over 60.5 (-110)

Florida Gators @ Ole Miss Rebels Odds

This was supposed to be the make or break year for Gators head coach Billy Napier. Well, it broke and Napier was fired after the Gators started the season 3-4. Last year, one of the things that saved Napier’s job at season’s end was the 24-17 win at home over Ole Miss.

The win gave Florida the series lead 13-12-1. The Gators have actually won the last three meetings, but they are the only three meetings since 2003.

Ole Miss just got done pounding on The Citadel 49-0 last week. It was the Rebels third straight win after their only loss of the season to Georgia.

Florida Gators @ Ole Miss Rebels Predictions

At the start of the season, we told you to watch out for Ole Miss QB Austin Simmons. Little did we know that head coach Lane Kiffin had an even better quarterback waiting in the wings. When Simmons went down with an injury, Trinidad Chambliss stepped in and the Rebels offense is even better.

Chambliss won an NCAA Division II national championship with Ferris State (Mich.) last season. This year, he’s completing 64 percent of his passes for 2,356 yards, 13 touchdowns, and just two interceptions.

The Ole Miss offense hasn’t missed a beat with Chambliss in control. The Rebels defense has actually improved throughout the season. They are a top-25 scoring defense allowing 19.8 points per game. Ole Miss also ranks 18th against the pass.

Florida’s offense is in a state of disarray. Starting QB D.J. Lagway was benched in the second half of last week’s loss to Kentucky. It was Lagway’s fourth game with multiple interceptions (3). He is expected to start this week, but the Gators only average 20.4 points per game (120th). Florida has scored more than 20 points in only two of their games all season.

Bet: ML pass, Ole Miss -16.5 (-108), Under 53.5 (-105)

Texas Longhorns @ Georgia Bulldogs Odds

We thought this game might be a preview of the SEC championship or even the national championship. Times have changed and Texas is now fighting for its playoff life. The Longhorns only have two losses, but a third would almost certainly remove them from playoff consideration.

These two historic football programs have only played each other seven times. Texas owns a 4-3 lead, but the Bulldogs beat the Longhorns twice last year. They got the win last year when the two met for the 2024 SEC championship and also beat Texas 30-15 during the regular season.

Texas Longhorns @ Georgia Bulldogs Predictions

In both of those games last year, Georgia was the underdog. They were a 4-point road underdog at Texas in the regular season and then a 3-point dog in the SEC title game played at Mercedes-Benz Stadium in Atlanta.

The Bulldogs are now 6-point favorites on their home field in Athens. The two teams are a lot alike. Both have powerful defenses. Georgia has taken some heat for giving up points, but they’ve only allowed more than 21 points twice – once in the loss to Alabama (24) and then to Ole Miss (35), one of the more explosive units in the country.

The Texas defense ranks No. 2 against the run and they only give up 16.4 points per game (11th). The Longhorns have given up more than 14 points just three times. Once in their loss to Florida and then in their last two games, wins Over Mississippi State and Vanderbilt.

QB Arch Manning has had a rough debut, but he played well last week. He’ll have to be sharp again this week if the Longhorns are to pull the upset. The line is definitely a Georgia line and the total suggests a lower-scoring game like last year’s SEC championship. Last year’s totals were 57 in the regular season and then 51 in the SEC title game.

Bet: Georgia -230, Georgia -6 (-110), Under 47.5 (-110)

Best College Football Week 12 Bets

Here are our favorite College Football bets for Week 12:

• Texas @ Georgia -6 (-110)
• Utah @ Baylor Over 60.5 (-110)
• Notre Dame @ Pittsburgh Over 55.5 (-105)

Notre Dame and Pittsburgh has been a traditional rivalry. The two teams don’t meet every year, but the last two times they’ve played, the game total was well below 50. This year, we see the total at 55.5 and both teams have high-powered offenses that can score. Back the Over.

It’s a similar story in Waco, Tex., where Baylor hosts Utah. The Bears are a pass-happy Air Raid team that can light up the scoreboard. Utah has a different approach, preferring to run the ball. The results are the same and the Utes actually average nearly 40 points per game. Utah has a great defense, but Baylor should be able to put up a few points. Last year’s game total was six points lower than this year’s.

Our last pick is Georgia and the line tells you all you need to know. Last year, the two teams met twice. The books backed Texas both times. The Bulldogs won both games. This time around, the books are on the Bulldogs laying six points. Georgia also has the advantage of playing at home.

If you want to add all three of our NCAAF Week 12 best bets to a parlay card, then you could earn $612 on a $100 wager. That’s a 6x per investment. If you like parlay cards, then check out our best College Football parlays. We also have weekly NFL parlay picks, as well.