I say it every week – it isn’t easy to predict upsets in college football. More than that, not that many even occur. We only got six in week five, but the good news is I was all over one of them, with the Oregon Ducks gracing my list.

Hopefully you were on them, and if so, you had some solid value (+150)and a winning pick. There was more where that upset pick came from, though, as I also hit on TCU against the spread. Sadly, the Ducks were my lone straight up play that turned out.

We continue to march closer to the 2025 College Football Championship, but ideally we rack up several more college football underdog picks before we get there. There is a lot to like for Week 6 in college football, but if you’re looking specifically for elite betting value, you’re in the right place.

Let’s dive into my favorite college football underdog picks for the week and what they look like together in a parlay.

College Football Week 6 Underdogs 

Team	Spread	Moneyline
New Mexico State Aggies	+2.5 (-105)	+120
UAB Blazers	+7 (-115)	+215
Boston College Eagles	+6 (EVEN)	+190
Iowa State Cyclones	+1.5 (-110)	EVEN

My college football underdog picks were just 1-3 last week, but I did hit a nice +150 bet, and I was pretty close on my TCU pick. Close doesn’t count for much in CFB betting, I know, so I’ll try to make it up to you with some winners in week six.

I have a four-pack to hand out again this week, starting with the New Mexico State Aggies. They get to host Sam Houston State, who I thought could be better than their winless start, but are an interesting favorite, to say the least.

I also think we’ll be getting solid value with UAB, Boston College, and Iowa State. The Cyclones are specifically the #14 team in the nation right now, and they’re projected to lose to an unranked opponent.

Boston College isn’t one I’d target heavily straight up, but I like the price and the spread. They’ve been in some wild games this year and I think they can hang tight and win us some money – even if it’s not on the moneyline.

You can roll with my college football underdogs as they stand, or read on for a little more insight into why I like each bet in week six.

College Football Underdog Picks

Check out our best College Football underdogs this week:

Sam Houston State (-140) vs. New Mexico State (+120)

The first week six college football underdog pick on my radar is the New Mexico State Aggies. They are compelling underdogs despite being at home and having a respectable 2-2 record, while they play host to the winless (0-4) Sam Houston State.

It’s fair to point out that New Mexico State has struggled lately. Following a 2-0 start where their defense looked tough, they gave up 49 and 38 points in consecutive crushing defeats. It appears the sportsbooks are concerned with the sudden drop in defense, combined with the uptick in competition.

The latter doesn’t exactly apply to Sam Houston State, though. The Bearkats have been far worse than New Mexico State, as they’ve allowed 37+ points in all four of their games and sunk to new lows last week in a crushing 55-0 loss to Texas.

Nobody is going to shame them for losing to the Longhorns, but Sam Houston State hasn’t been remotely competitive at any point so far in 2025. They are putting up just 16 points per game on offense, while their defense ranks 130th in scoring.

I’ll back the better-looking home dog in this one. 

Army (-260) vs. UAB (+215)

I don’t mind the UAB Blazers as a straight up underdog bet, but I do think we are better off chasing their 7-point spread. This gives you a little wiggle room in case the Blazers have any issues handling Army, but I’m not too worried that will be the case.

UAB enters as a sizable underdog, but we don’t need them to win for us to cash. I still don’t hate their chances, seeing as the Blazers will be at home in this one and are facing a struggling Army program that is just 1-3 on the year.

To this point, the Black Knights have only beaten Kansas State, and last week couldn’t muster anything on offense in a 28-6 loss to East Carolina. On the season, they’ve mustered respectable offensive production with an elite ground game, but have predictably struggled through the air and have been terrible on defense.

UAB could exploit Army’s main issues, especially on offense. They’re just 2-2 through four weeks, but they’ve been fairly dynamic on offense, scoring 24+ points in every single contest and ranking inside the top 70 in the nation in scoring. They’ve been especially explosive through the air, where they grade out as the 4th best passing offense by the numbers.

UAB does leave a lot to be desired defensively, and I doubt they are going to shut Army’s running game down. However, if this game turns into a shootout, it’s hard not to favor the Blazers at home. And again, they don’t even have to win the game to hit. 

Boston College (+190) vs. Pittsburgh (-230)

We have another similar situation with the Boston College Eagles this week, as we get six more points to work with when they take on Pittsburgh on the road. This is not an ideal spot for Boston College, and they are off to a rough 1-3 start through four weeks.

It hasn’t been good, but the Eagles did put up 66 points in their lone victory back in week one, and they’ve been in all three of their losses. One was a wild 42-40 shootout loss to the Michigan State Spartans, and last week they fell by just four (28-24) to California.

None of this means Boston College is necessarily a team we can trust, but they’ve been competitive and they have an offense that can put up some points – most notably through the air with the nation’s 13th best pass attack.

A lot of their success can be attributed to quarterback Dylan Lonergan, who has put up nine touchdowns and 1,188 yards already. He figures to be able to find some success in this matchup, seeing as Pittsburgh is giving up over 27 points per game and ranks outside of the top 100 at defending the pass.

Pittsburgh has dropped their last two games, too, and they’ve struggled more as their competition has improved. It could go either way as far as how good anyone deems Boston College to be, but from what I’ve seen, they’re good enough to at least make a game of it. 

Iowa State (EVEN) vs. Cincinnati (-120)

Lastly, we have what I feel is an insane value with the Iowa State Cyclones. This is the 14th ranked team in all of college football, and yet they are underdogs on the road against an unranked Cincinnati Bearcats squad.

To be fair, Cincy is a solid 3-1 through four games, with their only defeat coming at the start of the season in a tight 20-17 game with Nebraska. Since then, they’ve been on fire with 34+ points in every game. That hot run includes last week’s wild 37-34 win over Kansas, as well as an absurd 70-0 thrashing versus NW State in week three.

Cincinnati is no slouch. They do present a tough test with an extremely balanced and dynamic offense, as well as a defense that offers a strong pass rush and has looked good overall.

The value lies with the Cyclones, however, because Iowa State is off to a scorching hot 5-0 start. Iowa State has won in a number of ways, edging out a hard-nosed defensive team like Iowa, and completely demolishing a more balanced team like Arizona.

The Cyclones presently occupy first place in the Big 12 thanks to a respectable offense that can be effective both through the air and on the ground. However, their meal ticket has been their nasty defense, which ranks 50th in the entire country against the pass, 41st against the run, and 15th in scoring.

Ultimately, Iowa State’s defense should continue to suffocate, and their center (Dante Moore) has been in better form than the uber-hyped Allar.

College Football Underdog Parlay

• New Mexico State Aggies (+120)
• UAB Blazers ATS +7 (-115)
• Boston College Eagles ATS +6 (EVEN)
• Iowa State Cyclones (EVEN)

The actual college football odds can change depending on which sports betting sites you’re using, but all of these teams should be priced as underdogs no matter where you look.

I would definitely encourage you to shop around for the best possible price, but for the most part if you put up $100 on this week 6 college football parlay, you can expect a return of about $1,545 if it hits.

As noted, nailing CFB underdogs is no easy task (let alone four of them in the same parlay), so I do suggest targeting these bets individually if you can exercise some restraint. That said, chasing big wins is fun, and this is not just a grouping of four ML wagers (two of these are ATS).

If you want to go for it all, you could replace the ATS bets with Boston College and UAB as straight up winners, and suddenly that hefty $1.5k gets even bigger.

If you’re down to stack bets, consider our top College Football parlays of the week. And for the NFL bettors out there, be sure to check out the best NFL parlays we’re cooking up to start the year off on a winning note.

Best College Football Underdog Picks For Week 6

The top handicappers often say two things quite frequently; mind your budget and be sure to diversify your betting portfolio.

Another one I’ll (constantly) add is to make sure you refrain from going too crazy with your NCAAF parlays. Hitting a big string of picks is fun, but it’s not something most bettors are going to do on a consistent basis. If you insist on doing it, either be selective with your bets or simply keep an eye on your bankroll when doing it.

For week 6, whether you’re targeting a full parlay or not, I’d start all underdog action off with UAB at +7. I think demanding a win is a bit of a stretch, but there’s nothing about this matchup that makes me think they can’t at least keep it within a touchdown.