Ten weeks down and only a month to go in the 2025 college football season. The conference races are really heating up and Week 11 brings the rabid college football fan what he or she has been waiting for all season – MAC-tion!

Week 10 brought us some solid Sun Belt and Conference USA mid-week action, but this week marks the final push of the regular season. That means it’s time for the MAC to give us plenty of mid-week treats and new conference member Massachusetts kicks it off for us when the Minutemen travel to Akron on Tuesday night. The other Tuesday MAC matchup should be a good one between Miami and Ohio, the two teams that played for the conference title in 2024.

These final weeks of the regular season will play a huge role in determining the field for the 2025 College Football Playoffs. There are a number of key games in the Big Ten and SEC that could go a long way in determining how many playoff spots both of those conferences receive.

As we look ahead to Week 11 of the college football schedule, make sure you are checking ScoresandStats on a daily basis from now until the college football national championship game. Our NCAAF experts will continue to provide inside analysis, free picks, game predictions, and more!

College Football Week 11 Schedule

College Football Week 11 Odds

Keep an eye on the latest College Football odds from the top online betting sites and monitor how the lines change throughout the week.

Most college football Week 11 lines are not available yet, but sportsbooks will start posting them closer to the start of the 2025 season and closer to Week 11.

Make sure you check ScoresandStats top handicappers each week of the college football season. They can help you understand how to approach some of these big point spreads and game totals.

Win your NCAAF Bets
With The Industry’s Best

Handicapping Membership

Get Free Trial

College Football Week 11 Predictions

Let’s take a look at the featured College Football Week 11 games and make our NCAAF picks for each game.

Tulane Green Wave @ Memphis Tigers Odds

Tulane and Memphis have played in each of the last 11 seasons. The road team has won each of the last two games in the series. The Tigers went 11-2 last season and beat the Green Wave in New Orleans in the final regular season game of the season.

The Tigers covered the spread in their first three games last season, but only covered in three of their remaining 10. Memphis had one of the best offenses in the country last season, finishing in the top 20 in both scoring (35.7 ppg, 13th) and total offense (444.5, 16th). This year, the Tigers will not have four-year starter Seth Henigan at quarterback.

Tulane’s offense finished seventh in the nation last year in scoring. The Green Wave averaged 36.7 points per game led by QB Darian Mensah, who transferred to Duke. Tulane also lost leading rusher Makhi Hughes to Oregon. The defense finished in the top 25 in both scoring defense (19.5 ppg, 18th) and total defense (321.9 ypg, 24th). Three starters are back plus the transfer portal brought in three starters from other FBS programs.

Tulane Green Wave @ Memphis Tigers Predictions

While neither team will have its starting quarterback from last year, the Green Wave got a huge boost when former BYU QB Jake Retzlaff announced he would be transferring. Retzlaff helped lead the Cougars to an 11-2 record last year and a bowl win.

Louisville transfer Maurice Turner will be the running back and Retzlaff has plenty of talented receivers in Bryce Bohannon, former Alabama transfer Shazz Preston, and FAU transfer Omari Hayes. Only three starters return on Tulane’s defense, but head coach Jon Sumrall is a defensive-minded head coach.

On the other end, Memphis will have a difficult time replacing Henigan. Nevada transfer Brendon Lewis gets the first crack at it. Only two offensive starters return and only one on a Tigers defense that gave up 37 or more points four times last season. Don’t forget, the road team has won each of the last two games in this series.

Bet: Tulane Green Wave (NA)

LSU Tigers @ Alabama Crimson Tide Odds

Alabama rules this Deep South rivalry that has been dubbed the “First Saturday in November” as well as the “Saban Bowl” since both teams had Nick Saban as a head coach. The Crimson Tide is 57-27-5 lifetime versus LSU and Alabama has won each of the last two in the series, both by double-digit margins.

The Tide has won 12 of the last 14 games against the Tigers. LSU last won in 2022, winning 32-31 in overtime. That game was in Baton Rouge. LSU’s last win in Tuscaloosa came during the 2019 season when the Tigers went unbeaten, won the SEC title, and went on to win the CFP national championship.

LSU Tigers @ Alabama Crimson Tide Predictions

Kalen DeBoer may be known for his prolific offenses and Alabama’s should be very good again. DeBoer doesn’t get enough credit for his defenses. The Tide finished ranked No. 10 in scoring defense last year, allowing opponents just 17.4 points per game. They were 21st in total defense (320.1 ypg).

Last year, the Under cashed in six of Alabama’s last seven games. That’s because the Tide held all seven opponents to 24 points or less. LSU’s defense needs some help. The Tigers have four starters back. The key returnee for LSU is QB Garrett Nussmeier who should lead one of the better offenses in the country. LSU had the No. 7 passing offense in the country last year.

It’s hard to bet against the Crimson Tide at home, especially when the line is less than a full touchdown. The last time LSU won in Tuscaloosa, Joe Burrow was the Tigers quarterback. Garrett Nussmeier is back for LSU and while he’s good, he’s no Joe Burrow. Plus, the Tigers don’t have a pair of receivers like Ja’Marr Chase and Justin Jefferson.

Bet: Alabama -6.5 (-110)

Florida Gators @ Kentucky Wildcats Odds

Florida head coach Billy Napier cooled his hot seat with four straight wins to end the 2024 season. The Gators beat Ole Miss, LSU, and rival Florida State then beat Tulane in the bowl game to end the season at 8-5.

Now, Florida travels to Kentucky where the Wildcats have won the last two games in the series against the Gators. In fact, the Wildcats won three straight from 2021 to 2023 before the Gators won 48-20 last year in Gainesville.

Kentucky went 4-8 last year, losing 6 of their last 7 games. The only win in that span was a 48-6 win over FCS Murray State. This year’s game against the Gators comes at the end of a murderous spree for Kentucky. Georgia, Texas, Tennessee, and Auburn all face the Wildcats in the four games prior to Florida.

Florida Gators @ Kentucky Wildcats Predictions

The Gators return seven starters to an offense that really started to gel as last season wore on. A lot of that was due to the play of QB D.J. Lagway, who was the No. 1 quarterback recruit in the class of 2024. After last season, Lagway will be a Heisman Trophy candidate.

The Gators defense was one of the better units in the nation over the last half of the season. Napier returns five starters to the defense, including both safeties. The Kentucky offense was miserable last season. The Wildcats ranked 124th in scoring, averaging 18.1 points per game last season.

Zach Calzada, who is on his fourth school, will start at quarterback. There are only three starters back on offense. That could be a good thing, but the Wildcats won’t have much experience. The defense could be in a bigger bind. Head coach Mark Stoops has just three starters returning on defense.

From 1987 until last season, Florida has won all but four games against Kentucky. The upturn started at the end of last season and it will continue for the Gators in 2025.

Bet: Florida Gators (NA)

Texas A&M @ Missouri Tigers Odds

These two newer SEC members have only played 17 times in college football history. Texas A&M leads the series 10 to 7. The Aggies won the last two games in the series. The most recent was last year when Texas A&M won big, 41-10.

It was one of just three losses for Missouri last season. The Tigers would lose three games, all in SEC play, all to ranked opponents. Missouri won all eight games in which it was the home team. The defense was very good, ranking in the top 25th in both scoring defense (20.4, 21st) and total defense (317.5, 17th).

The Tigers defense helped them cover the spread in seven of their final eight games of the season last year. The Aggies were a top-35 scoring defense, but they actually lost four of their last five games last season. They also went 0-5 ATS in their final five games.

Texas A&M @ Missouri Tigers Predictions

The Aggies return QB Marcel Reed, who should be even better in 2025. It was Texas A&M that actually led the SEC in scoring in conference games. The Aggie averaged 29.4 points per game and scored over 30 points in five of their eight SEC games.

Missouri will break in a new quarterback in Penn State transfer Beau Pribula. WR Luther Burden is gone to the NFL, but the Tigers do have TE Brent Norfleet and WR Joshua Manning back. The defense with seven returning starters could be even better than last year’s unit.

At home, the Tigers will be tough to beat at home. Missouri won all seven of its true home games last season. By this time in the season, Pribula and the Tigers offense should have found its groove.

Bet: Missouri Tigers (NA)

Indiana Hoosiers @ Penn State Nittany Lions Odds

Curt Cignetti and his Indiana Hoosiers won’t sneak up on anybody this season. Cignetti instantly changed the culture at Indiana and his team went 11-2 and earned a spot in the 12-team College Football Playoffs last season.

The Hoosiers were one of a very few CFB teams that was a top 10 team in both scoring offense and scoring defense. Indiana ranked No. 2 in yards allowed last year and No. 6 in scoring defense (15.6 ppg). The offense averaged 41.3 points per game, second-most in the nation.

Penn State was eighth in scoring defense (16.5 ppg) and averaged 33.1 points per game (28th) on offense. The Nittany Lions are the preseason favorite to win the Big Ten championship. They return a ton of talent on both sides of the ball.

The Nittany Lions own this series. They’ve won the last three meetings and nine of the last ten. Penn State wound up 13-3 last season, but they were just 8-8 ATS.

Indiana Hoosiers @ Penn State Nittany Lions  Predictions

As mentioned, the Nittany Lions are the favorites to win the Big Ten. These two teams did not play last season, but the Hoosiers will have to break in some new faces. QB Fernando Mendoza came over from Cal and Cignetti went back to the portal to restock his defense.

Penn State didn’t have to do much in terms of rebuilding their lineup, especially on offense. QB Drew Allar and RBs Kaytron Allen and Nick Singleton all passed on the NFL for one more shot at a Big Ten title and a CFP championship. This will be just another step toward both.

Bet: Penn State (NA)

Florida State Seminoles @ Clemson Tigers Odds

The Seminoles had an outlier of a season in 2024. They got off to a poor start with a loss in the kickoff game in Dublin. Then, it all went downhill from there. They lost six straight games, including a 23-19 loss to Clemson in Week 5, before getting a win over FCS Charleston Southern near the end of the season.

It just can’t get any worse or can it? Clemson has won eight of the last nine games against FSU and the Tigers are the favorite to win the ACC. Cade Klubnik and seven other offensive starters are back. Six starters return on defense. The Tigers are loaded and, after going 10-4 last season, they are ready to compete for another national championship.

Florida State? Not so much. Head coach Mike Norvell went deep into the portal to ensure that something like last year doesn’t happen again, but beating the Tigers at Clemson is something the Seminoles haven’t done since 2013.

Florida State Seminoles @ Clemson Tigers Predictions

The Seminoles will go with former BC QB Tommy Castellanos to run the offense. Only one starter returns. The Tigers have Klubnick, three starting wide receivers, and three starters on the offensive line are back. That offense last year averaged over 33 points per game, 19th in the nation.

The defense is loaded too and Clemson hired Tom Allen to take over as the defensive coordinator. He’s one of the best in the business and makes a Clemson defense even better. The Seminoles will be better than they were in 2024, but they won’t beat the Tigers in Death Valley.

Bet: Clemson Tigers (NA)

Navy Midshipmen @ Notre Dame Fighting Irish Odds

It’s one of college football’s great rivalries. Notre Dame has been playing the service academies since the beginnings of the sport. It’s no surprise that Notre Dame holds an 81-13-1 advantage in the series. The Fighting Irish have won the last seven games in the series. The last Navy win was in 2016, a 28-27 Midshipmen win.

The Navy triple option and now hybrid Wing-T will give the Irish some fits, but Notre Dame is just that much better. The Irish won last year 51-14. Navy returns a ton of talent on offense, including QB Blake Horvath and all three running backs.

The Middies defense only returns four starters and that will be the difference. The Irish bring back RB Jeremiyah Love, four starters on the offensive line, and the quarterback will be highly touted prospect C.J. Carr.

Navy Midshipmen @ Notre Dame Fighting Irish Predictions

Don’t forget, the Irish played for a national championship last year. They have all the tools to do it again in 2025. The defense returns five starters and a new defensive coordinator in Chris Ash. The Irish were third in the nation last year in scoring defense allowing 15.5 points per game. It’s hard to win games scoring 15 points per game.

Carr should be an adequate replacement for Riley Leonard at quarterback and the offense should continue to dominate. Notre Dame finished fifth in scoring, averaging 36.1 points per game last year. Navy will present some issues early in the game for Notre Dame, but in the end, talent wins out.

Bet: Notre Dame (NA)

Best College Football Week 11 Bets

Here are our favorite College Football bets for Week 11:

• Tulane to Win
• Penn State to Win
• Florida State -16.5
• Notre Dame to Win

We have a mixture of road and home teams this week. Yet, we need to see the odds for some of these matchups before recommending how many units to bet. Additionally, once these NCAAF odds are released, there could be some early value on the boards. And, lastly, we’ll also be able to consider which of our best picks that we want to roll into a parlay.