The San Francisco 49ers are the NFC West favorite at -320 on DraftKings, as ESPN listed the market at 11:27 UTC on Saturday, October 17, 2026. The Los Angeles Rams are +440, the Seattle Seahawks +640 and the Arizona Cardinals +15000. On October 13 the 49ers were -260, the Rams +425 and the Seahawks +495.
San Francisco is 5-0 and has beaten each of the other three teams once. Seattle opened Week 6 on Thursday with a 17-14 overtime loss at Denver and is 3-3. The Rams are 2-3 and Arizona is 1-4.
NFC West odds
| Team | Price | Implied chance | Share with the margin removed | Record |
|---|---|---|---|---|
| San Francisco 49ers | -320 | 76.2% | 70.0% | 5-0 |
| Los Angeles Rams | +440 | 18.5% | 17.0% | 2-3 |
| Seattle Seahawks | +640 | 13.5% | 12.4% | 3-3 |
| Arizona Cardinals | +15000 | 0.7% | 0.6% | 1-4 |
The NFC West winner market at DraftKings, as carried by ESPN at 11:27 UTC on October 17, 2026. Records come from ESPN’s standings at the same read and include Thursday’s game.
Since the October 13 read, Seattle is the only one of the four to have played.
The 49ers’ -320 means $320 staked to win $100, and a break-even rate of 320 in 420, or 76.2%. The Rams at +440 need 18.5% and the Seahawks at +640 need 13.5%.
The four rates add to 108.9%, a margin of 8.9 points for the book. Take the margin out and San Francisco holds 70.0% of the market, the Rams 17.0%, Seattle 12.4% and Arizona 0.6%.
No NFC West pick is made here. The question a bettor has to answer is whether San Francisco wins this division more than 76.2% of the time, and the rest of the page is laid out for that. Settlement rules are in the futures bet guide.
NFC West standings
| Team | Record | Division | Conference | Points for | Points against | Difference | Games behind |
|---|---|---|---|---|---|---|---|
| San Francisco 49ers | 5-0 | 3-0 | 3-0 | 154 | 93 | +61 | – |
| Seattle Seahawks | 3-3 | 1-1 | 1-2 | 148 | 122 | +26 | 2.5 |
| Los Angeles Rams | 2-3 | 0-1 | 2-1 | 119 | 120 | -1 | 3 |
| Arizona Cardinals | 1-4 | 0-2 | 0-4 | 108 | 162 | -54 | 4 |
ESPN’s standings read at 11:27 UTC on October 17, 2026. Seattle has played six games and the other three five.
San Francisco is 3-0 inside the division and has outscored its opponents by 61. Seattle’s point difference is +26, and it has lost its last two: 32-29 at home to the 49ers on October 11 and 17-14 in overtime at Denver on Thursday. The Rams have scored 119 points and allowed 120, and they are three games behind. Arizona has given up 162 and lost four straight.
Next game for each NFC West team
| Game | Kickoff | Spread | Moneyline | Total | Our page |
|---|---|---|---|---|---|
| Cardinals at Rams | Sun, October 18, 4:05 pm ET | Rams -12.5 (-112), Cardinals +12.5 (-108) | Rams -800, Cardinals +550 | Over 51.5 (-112), Under 51.5 (-108) | Cardinals at Rams prediction |
| Commanders at 49ers | Mon, October 19, 8:15 pm ET | 49ers -7.5 (-108), Commanders +7.5 (-112) | 49ers -425, Commanders +330 | Over 52.5 (-105), Under 52.5 (-115) | |
| Chiefs at Seahawks | Sun, October 25, 8:20 pm ET | no line listed | no line listed | no line listed |
DraftKings lines from ESPN at 11:27 UTC on October 17, 2026. Cardinals at Rams on October 18 is the next game inside the division. Seattle’s next game, at home to Kansas City on October 25, had no line listed yet.
NFC West division games left
| Week | Game | Kickoff |
|---|---|---|
| 6 | Cardinals at Rams | Sun, October 18, 4:05 pm ET |
| 9 | Cardinals at Seahawks | Sun, November 8, 4:25 pm ET |
| 10 | Rams at Cardinals | Sun, November 15, 4:05 pm ET |
| 12 | Seahawks at 49ers | Sun, November 29, 4:25 pm ET |
| 14 | Rams at 49ers | Sun, December 13, 4:25 pm ET |
| 16 | Rams at Seahawks | Fri, December 25, 8:15 pm ET |
| 18 | 49ers at Cardinals | January 10, time not set |
| 18 | Seahawks at Rams | January 10, time not set |
ESPN lists the two Week 18 games by date only.
Eight division games are left and San Francisco is in just three of them: Seattle at home on November 29, the Rams at home on December 13 and a trip to Arizona in Week 18. The Rams have five to play, the most of the four, and Seattle and Arizona have four each.
The four already played:
| Week | Date | Game | Result |
|---|---|---|---|
| 1 | September 10 | 49ers at Rams (neutral site: Melbourne, Australia) | 49ers 27, Rams 7 |
| 2 | September 20 | Seahawks at Cardinals | Seahawks 31, Cardinals 7 |
| 3 | September 27 | Cardinals at 49ers | 49ers 36, Cardinals 30 |
| 5 | October 11 | 49ers at Seahawks | 49ers 32, Seahawks 29 |
The opener between the 49ers and the Rams was played in Melbourne, with the Rams as the designated home team.
What each NFC West price needs
San Francisco, -320. The 49ers need 76.2%. They lead Seattle by two and a half games, hold a win over all three rivals and have two of their last three division games at home.
Los Angeles, +440. $100 wins $440 and needs 18.5%. The Rams are the second choice at 2-3, with a 20-point loss to San Francisco, and they have more division games left than anyone.
Seattle, +640. $100 wins $640 and needs 13.5%. The Seahawks have one more win than the Rams and a longer price. Both of their games with the Rams are still ahead, on December 25 and in Week 18.
Arizona, +15000. $100 wins $15,000 and needs 0.7%. The Cardinals are 0-2 in the division and four games behind.
The NFC West last season
| Team | Record | Division | Points for | Points against |
|---|---|---|---|---|
| Seattle Seahawks | 14-3 | 4-2 | 483 | 292 |
| Los Angeles Rams | 12-5 | 4-2 | 518 | 346 |
| San Francisco 49ers | 12-5 | 4-2 | 437 | 371 |
| Arizona Cardinals | 3-14 | 0-6 | 355 | 488 |
Seattle won the division at 14-3 and was the NFC’s top seed. The Rams and 49ers both finished 12-5, and all three went 4-2 inside the division. Arizona was 3-14 and lost all six division games.
More NFL odds pages
Each club’s games and our predictions sit on its team page: San Francisco 49ers, Seattle Seahawks, Los Angeles Rams, Arizona Cardinals.
Prices for the rounds after the division are on NFC Championship odds and Super Bowl odds. Every NFL game we cover is on the NFL picks and predictions hub. The PicksToday handicappers sell their own NFL picks.