Rams vs Cardinals prediction: take the over 39.5. Our number for this total is 48.78, more than nine points above the market.

Upcoming games
The Rams covered 12 times in 17 in 2025, a rate no NFL team beat, yet a unit on them to win every game finished 0.51 units down. They were favorites in 15 of their 17 games; each coming game is listed above with the Rams odds and our prediction.
Covers at the top of the league
Los Angeles finished the 2025 regular season 12-5, and 12-5 against the spread as well. Three other teams covered 12 times; none covered more. The Rams also scored 30.47 points a game, the most in the NFL.
Most of it came as the favorite. The Rams gave points in 15 of their 17 games, won 12 of those and covered 11, a rate only two NFL teams bettered. At home they were 7-1 and covered six of eight; only the Jacksonville Jaguars had a better home cover rate, and the Cleveland Browns matched it. Away they covered five of eight, and the London game, a 35-7 win over the Jaguars, covered too.
Why the moneyline did not follow
Backing the Rams to win in all 17 games returned 0.51 units less than was staked. The 12 favorite wins paid fractions, down to 0.06 units for a 34-10 win over the New Orleans Saints at -1600. Three favorite losses cost a full unit each: 31-28 at the Carolina Panthers at -575, 26-23 at home to the San Francisco 49ers at -450, and 27-24 at the Atlanta Falcons at -375. The 15 favorite games together made 1.49 units: 4.49 from the wins, less 3 for those losses. The two underdog games, both lost, took away 2.
By venue the split was sharper: home games made 1.54 units, road games lost 2.62.
The NFC West
Los Angeles went 4-2 in the division and 4-2 against the spread. Both games with the Arizona Cardinals were wins and covers. The San Francisco 49ers split with one cover. So did the Seattle Seahawks, and the Rams’ cover there came in a 38-37 loss as 1.5-point underdogs. In January the Rams won 34-31 at Carolina and 20-17 at Chicago, then lost the NFC Championship 31-27 at Seattle.
The total
Ten overs, seven unders; seven NFL teams went over more often, so no lean.
Questions and answers
How often did the Rams cover in 2025?
12 times in 17 regular-season games, tied with three teams for the most in the NFL.
Why did backing the Rams to win lose money in 2025?
They were favorites in 15 games. The 12 wins as favorites returned 4.49 units, and the three losses, at -575, -450 and -375, cost 3; the two underdog games cost 2 more.
Where did the Rams’ 2025 season end?
In the NFC Championship, a 31-27 loss at Seattle, after road wins at Carolina and Chicago.
NFL teams
Arizona Cardinals
Atlanta Falcons
Baltimore Ravens
Buffalo Bills
Carolina Panthers
Chicago Bears
Cincinnati Bengals
Cleveland Browns
Dallas Cowboys
Denver Broncos
Detroit Lions
Green Bay Packers
Houston Texans
Indianapolis Colts
Jacksonville Jaguars
Kansas City Chiefs
Las Vegas Raiders
Los Angeles Chargers
Los Angeles Rams
Miami Dolphins
Minnesota Vikings
New England Patriots
New Orleans Saints
New York Giants
New York Jets
Philadelphia Eagles
Pittsburgh Steelers
San Francisco 49ers
Seattle Seahawks
Tampa Bay Buccaneers
Tennessee Titans
Washington Commanders