49ers Odds and Predictions: San Francisco Home and Away Skip to content
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San Francisco 49ers

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Past Game Predictions Result

Upcoming games

Away from home the 49ers covered seven of nine games in 2025; at home they covered three of eight. 49ers odds made San Francisco the favorite 11 times and they won ten, and our 49ers predictions for this season are above.

Better on the road

San Francisco’s 2025 regular season ended 12-5, with the spread beaten in 10 of 17 games: a rate that five teams bettered and three equalled. The split behind it is the story: 7-2 straight up away from home with seven covers, and only two teams covered a higher share of road games.

The 49ers 2025 regular season, game by game2025-09-07 at Seattle Seahawks 17-132025-09-14 at New Orleans Saints 26-212025-09-21 v Arizona Cardinals 16-152025-09-28 v Jacksonville Jaguars 21-262025-10-02 at Los Angeles Rams 26-232025-10-12 at Tampa Bay Buccaneers 19-302025-10-19 v Atlanta Falcons 20-102025-10-26 at Houston Texans 15-262025-11-02 at New York Giants 34-242025-11-09 v Los Angeles Rams 26-422025-11-16 at Arizona Cardinals 41-222025-11-24 v Carolina Panthers 20-92025-11-30 at Cleveland Browns 26-82025-12-14 v Tennessee Titans 37-242025-12-22 at Indianapolis Colts 48-272025-12-28 v Chicago Bears 42-382026-01-03 v Seattle Seahawks 3-13Wins above the line, losses below; bar length is the margincovered the spreaddid not cover0
12-5 in 17 games. Source: ESPN results and pre-game lines.

At home the same team went 5-3 and covered three of eight. On that measure 24 clubs were ahead of them and four level.

Favorite or underdog

Laying points was where they paid. As favorites the 49ers went 10-1 straight up and covered eight of 11; only three of the 31 teams favored at least once did better, and one matched them. The single loss was 21-26 at home to the Jacksonville Jaguars at -170.

The 49ers at home, away, as favorite and as underdogHome (8)won 5 (62.5%)covered 3 of 8 (37.5%)Away (9)won 7 (77.8%)covered 7 of 9 (77.8%)Favorite (11)won 10 (90.9%)covered 8 of 11 (72.7%)Underdog (6)won 2 (33.3%)covered 2 of 6 (33.3%)50%
2025 regular season. Neutral-site games are in neither home nor away. Source: ESPN results and pre-game lines.

Getting points was another matter: 2-4 straight up and two covers in six. Twenty-nine teams covered more often as underdogs, and two matched it.

The moneyline, home and away

A unit on San Francisco in each of the 16 priced games came out 4.27 ahead, and seven NFL teams did better. Split by venue, the road games made 4.87 and the home games lost 0.60. The longest price that landed was 26-23 at the Los Angeles Rams in October, at +340 as 8.5-point underdogs.

One unit on the 49ers to win, every game0+1+2+3+4+5+4.27 unitsfirst gamelast game
Running total over 16 priced 2025 regular-season games, at the pre-game moneyline. Source: ESPN results and pre-game lines.

From mid-November to the end of December they won six straight. Then the regular season ended on a 3-13 home loss to Seattle at +130.

NFC West

Four wins in six. Two over the Arizona Cardinals, 16-15 at home and 41-22 at Arizona, one cover. A split with the Los Angeles Rams: the October win, then 26-42 at home, one cover. A split with the Seattle Seahawks: 17-13 at Seattle in the opener, covered, and the home loss in the finale. In the playoffs, a 23-19 Wild Card win at Philadelphia and a 6-41 Divisional loss at Seattle.

The total

The total went over in ten games and under in seven, a share seven clubs topped and five tied. The 49ers scored 25.71 points a game, and nine teams scored more.

Questions and answers

Were the 49ers a better bet away than at home in 2025?

Against the spread, yes: seven covers in nine road games against three in eight at home.

How often did the 49ers lose as favorites in 2025?

Once in 11: 21-26 at home to Jacksonville.

Where did the 49ers’ 2025 postseason end?

At Seattle, 6-41 in the Divisional round, a week after a 23-19 Wild Card win at Philadelphia.

Past Game Predictions Result

  1. Raiders at 49ers · 8 NovUnder 52
  2. 49ers at Falcons · 25 OctUnder 49.5
  3. Commanders at 49ers · 19 OctUnder 52
  4. 49ers at Seahawks · 11 OctSeahawks -3
  5. Broncos at 49ers · 4 OctSan Francisco is laying 2.5 to a team that had the better season last year.
  6. Cardinals at 49ers · 27 SepPick: Cardinals +8.5.
  7. Dolphins at 49ers · 20 SepSan Francisco won 35-13.

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