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Broncos 1-1 and 49ers 2-0. Here is where this game stands.
The game
The Broncos visit the 49ers on Sunday 4 October at 4:25 PM ET. The game is in San Francisco.
Last season finished with the 49ers at 12-5 and the Broncos at 14-3. They did not meet in the data we hold, which starts with the 2025 season.
This season so far
In Week 1 the Broncos lost to the Chiefs 10-31 on the road. In Week 2 the Broncos beat the Jaguars 20-13. In Week 1 the 49ers beat the Rams 27-7 on the road. In Week 2 the 49ers beat the Dolphins 35-13.
The early line
The early line has the 49ers at -2.5, the median of 3 books. The total is 46.5 across 3 books.
These are look-ahead prices, read 11 Sep 00:10 UTC, and only 3 books were quoting the spread. With the bookmaker margin removed, the moneyline makes the 49ers 57.2% to win. Expect them to move once the weeks in between are played.
Denver Broncos at San Francisco 49ers, Sunday 4 October at 4:25 PM ET. Prices: US sportsbooks via Nucleus, read 11 Sep 00:10 UTC. 2025 results: Nucleus, checked game by game against ESPN. Every Week 4 game: NFL Week 4 odds and predictions.
