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NFL Week 15 Picks – Must-Win Matchups and December Betting Strategy
Week 15 is do-or-die territory for a lot of teams—and that means high volatility and even higher value for bettors. With playoff berths on the line and rosters being tested, Scores and Stats is breaking down the sharpest ways to navigate one of the most unpredictable weeks of the NFL season.
Whether it’s a veteran QB leading a late surge or a young defense making waves, our NFL picks for Week 15 focus on real-time form, situational metrics, and high-impact matchups. No hype, just proven insight built for this stage of the season.
2025 NFL Week 15 Schedule
This week’s schedule features teams clinging to playoff hopes, squads shifting to survival mode, and a few that are out—but still dangerous. That mix of desperation and unpredictability creates prime spots for savvy bettors to strike.
We kick things off Thursday with a game that could reshape an entire division, then head into a jam-packed Sunday before a pivotal Monday Night Football matchup where playoff seeding is on the line. It’s a betting board full of pressure and potential—exactly what we love.
| Date | Matchup | Time | Location |
|---|---|---|---|
| Thursday, December 11, 2025 | Atlanta @ Tampa Bay | 7:15 PM | Raymond James Stadium, Tampa, FL |
| Sunday, December 14, 2025 | Cleveland @ Chicago | 12:00 PM | Soldier Field, Chicago, IL |
| Sunday, December 14, 2025 | Baltimore @ Cincinnati | 12:00 PM | Paycor Stadium, Cincinnati, OH |
| Sunday, December 14, 2025 | Los Angeles @ Kansas City | 12:00 PM | GEHA Field at Arrowhead Stadium, Kansas City, MO |
| Sunday, December 14, 2025 | Buffalo @ New England | 12:00 PM | Gillette Stadium, Foxborough, MA |
| Sunday, December 14, 2025 | Washington @ New York | 12:00 PM | MetLife Stadium, East Rutherford, NJ |
| Sunday, December 14, 2025 | Las Vegas @ Philadelphia | 12:00 PM | Lincoln Financial Field, Philadelphia, PA |
| Sunday, December 14, 2025 | New York @ Jacksonville | 12:00 PM | EverBank Stadium, Jacksonville, FL |
| Sunday, December 14, 2025 | Arizona @ Houston | 12:00 PM | NRG Stadium, Houston, TX |
| Sunday, December 14, 2025 | Green Bay @ Denver | 3:25 PM | Empower Field at Mile High, Denver, CO |
| Sunday, December 14, 2025 | Detroit @ Los Angeles | 3:25 PM | SoFi Stadium, Inglewood, CA |
| Sunday, December 14, 2025 | Carolina @ New Orleans | 3:25 PM | Caesars Superdome, New Orleans, LA |
| Sunday, December 14, 2025 | Tennessee @ San Francisco | 3:25 PM | Levi’s Stadium, Santa Clara, CA |
| Sunday, December 14, 2025 | Indianapolis @ Seattle | 3:25 PM | Lumen Field, Seattle, WA |
| Sunday, December 14, 2025 | Minnesota @ Dallas | 7:20 PM | AT&T Stadium, Arlington, TX |
| Monday, December 15, 2025 | Miami @ Pittsburgh | 7:15 PM | Acrisure Stadium, Pittsburgh, PA |
NFL Handicapping Leaderboard
Our Top Handicappers are diving deep into Week 15, examining weather shifts, quarterback splits, and how teams perform with season-defining stakes. These aren’t just picks—they’re battle-tested calls designed for December chaos.
ATS picks, over/unders, moneylines—we’ve got every angle covered. Whether you’re managing risk or taking your shot with a bold parlay, our Week 15 betting predictions are here to anchor your weekend plays.
NFL Week 15 Picks
Explore our detailed NFL Week 15 odds and predictions to see where the books are vulnerable and where sharp money is shifting. It’s one of the final weeks to gain ground—don’t waste a line.
Make Your Playoff Push with Week 15 Picks from Scores and Stats
In December, every point counts—and so does every bet. Let Scores and Stats give you the intel you need to outsmart the market, capitalize on late-season edges, and close the season strong.
Stay in the game with us on Instagram @scoresandstats, follow sharp movements live on X @scoresand_stats, and subscribe on YouTube for injury updates, weather alerts, and betting breakdowns leading up to kickoff.
From live NFL odds to expert game previews, our team is here to give you everything you need to bet smarter in Week 15 and beyond.
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