NFL Previews 
MLB Previews 
NBA Previews 
NHL Previews 
Soccer Previews 
NFL Week 4 Picks – Sharp Handicappers Weigh in on This Week’s Top Bets
As Week 4 of the 2025 NFL season kicks off, which teams are showing early signs of dominance—and which underdogs are being overlooked? Our expert team at Scores and Stats has dug into the data to spotlight this week’s smartest betting angles.
Looking to build your winning ticket? Don’t miss the three teams our analysts are circling as must-bet opportunities. Check out the most recent NFL picks and head to our members’ area to access exclusive breakdowns, trends, and insider edges straight from our veteran handicappers.
2025 NFL Week 4 Schedule
The Week 4 schedule is packed with pivotal matchups that could shape early division races and wild card narratives. Whether it’s a cross-conference clash or a heated rematch, each game is loaded with betting potential and storylines worth following.
Starting with a primetime Thursday Night Football battle and closing out with a high-stakes Monday night showdown, this week’s lineup is built for action. Use our full Week 4 schedule to plan your bets and your viewing weekend.
| Date | Matchup | Time | Location |
|---|---|---|---|
| Thursday, September 25, 2025 | Seattle @ Arizona | 6:15 PM | State Farm Stadium, Glendale, AZ |
| Sunday, September 28, 2025 | Minnesota @ Pittsburgh | 7:30 AM | Croke Park, Dublin, Ireland |
| Sunday, September 28, 2025 | Washington @ Atlanta | 11:00 AM | Mercedes-Benz Stadium, Atlanta, GA |
| Sunday, September 28, 2025 | New Orleans @ Buffalo | 11:00 AM | Highmark Stadium, Orchard Park, NY |
| Sunday, September 28, 2025 | Cleveland @ Detroit | 11:00 AM | Ford Field, Detroit, MI |
| Sunday, September 28, 2025 | Carolina @ New England | 11:00 AM | Gillette Stadium, Foxborough, MA |
| Sunday, September 28, 2025 | Los Angeles @ New York | 11:00 AM | MetLife Stadium, East Rutherford, NJ |
| Sunday, September 28, 2025 | Philadelphia @ Tampa Bay | 11:00 AM | Raymond James Stadium, Tampa, FL |
| Sunday, September 28, 2025 | Tennessee @ Houston | 11:00 AM | NRG Stadium, Houston, TX |
| Sunday, September 28, 2025 | Indianapolis @ Los Angeles | 2:05 PM | SoFi Stadium, Inglewood, CA |
| Sunday, September 28, 2025 | Jacksonville @ San Francisco | 2:05 PM | Levi’s Stadium, Santa Clara, CA |
| Sunday, September 28, 2025 | Baltimore @ Kansas City | 2:25 PM | GEHA Field at Arrowhead Stadium, Kansas City, MO |
| Sunday, September 28, 2025 | Chicago @ Las Vegas | 2:25 PM | Allegiant Stadium, Las Vegas, NV |
| Sunday, September 28, 2025 | Green Bay @ Dallas | 6:20 PM | AT&T Stadium, Arlington, TX |
| Monday, September 29, 2025 | New York @ Miami | 5:15 PM | Hard Rock Stadium, Miami Gardens, FL |
| Monday, September 29, 2025 | Cincinnati @ Denver | 6:15 PM | Empower Field at Mile High, Denver, CO |
NFL Handicapping Leaderboard
By this point in the season, patterns are starting to emerge—and that’s when savvy bettors gain an edge. Our Top Handicappers have been tracking trends, reading between the lines, and zeroing in on key matchups that offer serious value.
The leaderboard reflects sharp performance across early weeks, giving you a snapshot of who’s hot. With each passing game, the data gets stronger, and the picks get sharper. Let our proven experts guide your Week 4 plays with confidence.
NFL Week 4 Picks
This week’s NFL betting predictions are live—including spreads, totals, and money line picks—offering strategic options for both conservative bets and bold parlays. Every game brings opportunity; we’re here to help you spot it.
Level Up Your Week 4 Bets with Scores and Stats Experts
Don’t go into Week 4 without backup. Our expert picks, in-depth analysis, and matchup strategies are built to help you bet smarter—from Thursday night to the final whistle on Monday. Whether you’re chasing value or building a safe parlay, we’ve got you covered.
Join our community on Instagram @scoresandstats, follow us on X @scoresand_stats, and subscribe on YouTube for weekly updates, expert tips, and deeper dives into the biggest NFL stories.
We’re committed to bringing you premium betting coverage all season long. From up-to-the-minute odds to reliable previews and trusted insights, we’re your source for clear, actionable football content. Let us help you stay sharp and ahead of the curve.
Looking For Better Results?
Sign Up Now And Catch Up Instantly.
