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NFL Week 10 Picks – Late-Season Lines, Live Value, and Lock-Worthy Bets
The NFL season is flying by, and Week 10 marks the start of the real stretch run. With the playoff chase heating up and contenders starting to separate, our experts at Scores and Stats are uncovering the matchups that matter most—for bettors and bankrolls alike.
Don’t settle for stale narratives. Our latest NFL picks are based on cold, hard data—from passing efficiency and defensive splits to late-season coaching trends. Whether you’re betting favorites or sniffing out a live underdog, we’ve got your playbook.
2025 NFL Week 10 Schedule
This week features several pivotal games, including divisional battles with postseason implications and non-conference matchups that could trip up the betting public. Our breakdowns focus on where the value lies—not just where the spotlight shines.
The action kicks off with a gritty Thursday night showdown and rolls through a statement-packed Sunday slate, capped by a critical Monday Night Football matchup that could shift futures boards. Week 10 is full of angles—don’t miss your edge.
| Date | Matchup | Time | Location |
|---|---|---|---|
| Thursday, November 6, 2025 | Las Vegas @ Denver | 7:15 PM | Empower Field at Mile High, Denver, CO |
| Sunday, November 9, 2025 | Atlanta @ Indianapolis | 8:30 AM | Olympic Stadium Berlin, Berlin, Germany |
| Sunday, November 9, 2025 | New York @ Chicago | 12:00 PM | Soldier Field, Chicago, IL |
| Sunday, November 9, 2025 | Buffalo @ Miami | 12:00 PM | Hard Rock Stadium, Miami Gardens, FL |
| Sunday, November 9, 2025 | Baltimore @ Minnesota | 12:00 PM | U.S. Bank Stadium, Minneapolis, MN |
| Sunday, November 9, 2025 | Cleveland @ New York | 12:00 PM | MetLife Stadium, East Rutherford, NJ |
| Sunday, November 9, 2025 | New England @ Tampa Bay | 12:00 PM | Raymond James Stadium, Tampa, FL |
| Sunday, November 9, 2025 | New Orleans @ Carolina | 12:00 PM | Bank of America Stadium, Charlotte, NC |
| Sunday, November 9, 2025 | Jacksonville @ Houston | 12:00 PM | NRG Stadium, Houston, TX |
| Sunday, November 9, 2025 | Arizona @ Seattle | 3:05 PM | Lumen Field, Seattle, WA |
| Sunday, November 9, 2025 | Los Angeles @ San Francisco | 3:25 PM | Levi’s Stadium, Santa Clara, CA |
| Sunday, November 9, 2025 | Detroit @ Washington | 3:25 PM | Northwest Stadium, Landover, MD |
| Sunday, November 9, 2025 | Pittsburgh @ Los Angeles | 7:20 PM | SoFi Stadium, Inglewood, CA |
| Monday, November 10, 2025 | Philadelphia @ Green Bay | 7:15 PM | Lambeau Field, Green Bay, WI |
NFL Handicapping Leaderboard
By now, sharp bettors know the trends that hold weight. Our Top Handicappers are analyzing situational stats, team fatigue levels, and historical matchups to find soft lines before they close. This is where preparation turns into profit.
Our Week 10 predictions include a full slate of against-the-spread picks, totals, and moneyline insights—all backed by midseason metrics that matter. If you’re looking to tighten your betting strategy, this is the week to go all-in.
NFL Week 10 Picks
Check out our full lineup of NFL Week 10 betting predictions, complete with expert analysis, public vs. sharp money movement, and late-breaking injury updates that could swing a line.
Week 10 Confidence Starts with Scores and Stats
Week 10 is when good bettors turn great. With clearer trends, stronger reads, and expert guidance from Scores and Stats, you’re equipped to attack the board with confidence and consistency.
Keep the edge by staying plugged into our content across platforms—Instagram @scoresandstats, X @scoresand_stats, and YouTube. We deliver real-time betting advice, strategy sessions, and matchup analysis that goes deeper than the headlines.
From sharp NFL odds to trusted game previews, Scores and Stats is your complete NFL betting hub. Let’s make Week 10 count—and cash in together.
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