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NFL Week 3 Picks – Expert Analysis on Spreads, Totals, and Money Lines
Which teams are ready to take control in Week 3? The NFL experts at Scores and Stats have broken down the key matchups, dissected the trends, and uncovered the smartest plays on the board. Looking for that undervalued team with real upset potential? Our analysts have found it—and it’s not who you might expect.
Want to bet smarter this week? Which three teams deserve your full attention in Week 3? Check out the latest NFL picks below, and dive into our members’ area for exclusive insights on which teams are set to win and cover, all powered by the sharpest minds in sports betting.
2025 NFL Week 3 Schedule
Two weeks into the 2025 NFL season, momentum is building—and so is the intensity. Week 3 brings pivotal matchups and potential turning points as teams aim to establish themselves in the standings. Our trusted Top Handicappers are already spotting value plays and sleeper picks based on early-season trends.
From the NFL Thursday night opener in Philadelphia to Monday Night Football in Chicago, fans and bettors alike can gear up for a full weekend of action. Below is the complete Week 3 schedule, including game dates, times, and locations to help you plan your football weekend.
| Date | Matchup | Time | Location |
|---|---|---|---|
| Thursday, Sept 18, 2025 | Miami @ Buffalo | 6:15 PM | Highmark Stadium, Orchard Park, NY |
| Sunday, Sept 21, 2025 | Green Bay @ Cleveland | 11:00 AM | Huntington Bank Field, Cleveland, OH |
| Sunday, Sept 21, 2025 | Indianapolis @ Tennessee | 11:00 AM | Nissan Stadium, Nashville, TN |
| Sunday, Sept 21, 2025 | Cincinnati @ Minnesota | 11:00 AM | U.S. Bank Stadium, Minneapolis, MN |
| Sunday, Sept 21, 2025 | Pittsburgh @ New England | 11:00 AM | Gillette Stadium, Foxborough, MA |
| Sunday, Sept 21, 2025 | Los Angeles @ Philadelphia | 11:00 AM | Lincoln Financial Field, Philadelphia, PA |
| Sunday, Sept 21, 2025 | New York @ Tampa Bay | 11:00 AM | Raymond James Stadium, Tampa, FL |
| Sunday, Sept 21, 2025 | Las Vegas @ Washington | 11:00 AM | Northwest Stadium, Landover, MD |
| Sunday, Sept 21, 2025 | Atlanta @ Carolina | 11:00 AM | Bank of America Stadium, Charlotte, NC |
| Sunday, Sept 21, 2025 | Houston @ Jacksonville | 11:00 AM | EverBank Stadium, Jacksonville, FL |
| Sunday, Sept 21, 2025 | Denver @ Los Angeles | 2:05 PM | SoFi Stadium, Inglewood, CA |
| Sunday, Sept 21, 2025 | New Orleans @ Seattle | 2:05 PM | Lumen Field, Seattle, WA |
| Sunday, Sept 21, 2025 | Dallas @ Chicago | 2:25 PM | Soldier Field, Chicago, IL |
| Sunday, Sept 21, 2025 | Arizona @ San Francisco | 2:25 PM | Levi’s Stadium, Santa Clara, CA |
| Sunday, Sept 21, 2025 | Kansas City @ New York | 6:20 PM | MetLife Stadium, East Rutherford, NJ |
| Monday, Sept 22, 2025 | Detroit @ Baltimore | 6:15 PM | M&T Bank Stadium, Baltimore, MD |
NFL Handicapping Leaderboard
Two weeks into the 2025 NFL season, momentum is building—and so is the intensity. Week 3 brings pivotal matchups and potential turning points as teams aim to establish themselves in the standings. Our trusted Top Handicappers are already spotting value plays and sleeper picks based on early-season trends.
The leaderboard is quickly taking shape, offering bettors a glimpse into which experts are delivering consistent results. It’s the perfect time to track performance, study betting patterns, and follow the pros who are heating up as the season unfolds.
NFL Week 3 Picks
Our team at Scores and Stats has broken down the Week 3 NFL matchups with detailed picks across spreads, totals, and moneyline angles. Whether you’re betting single games or building a multi-leg parlay, we’ve got the insight you need to stay ahead of the game.
Dominate Week 3 with Scores and Stats’ Expert Picks
Week 3 is where early-season narratives start to shift. Get the expert analysis and betting recommendations you need to make the most of every game. Our sharp, stat-backed advice will help you navigate line movements, injury news, and matchup dynamics with confidence.
Join the Scores and Stats community for exclusive betting content, daily updates, and insider takes. You’ll find us on Instagram @scoresandstats, on X @scoresand_stats, and on YouTube—breaking down the week’s biggest storylines, spreads, and upsets before they hit the headlines.
From up-to-the-minute odds to reliable previews, our mission is to keep you informed, empowered, and a step ahead each week. If you’ve got thoughts or feedback, we’re always listening—we grow with our community.
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