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NFL Week 16 Picks – Holiday Heat and High-Stakes Handicapping
It’s the week of holiday chaos—and football glory. With just two weeks left in the regular season, Week 16 brings urgency, unpredictability, and plenty of betting gold. Whether you’re chasing a strong close or capitalizing on mispriced lines, Scores and Stats has you covered with sharp, data-driven picks.
Our NFL picks for Week 16 go beyond the surface—built on cold-weather performance, playoff pressure, and in-depth analytics that tell the truth behind the trends. It’s the perfect storm for smart bettors to take control of the board.
2025 NFL Week 16 Schedule
This week is packed with playoff clinching scenarios, spoiler matchups, and teams resting starters—or going all in. The volatility is real, and so is the opportunity if you know where to look.
Festivities start with a key Thursday night clash, followed by Saturday games for holiday weekend action, a Sunday full of playoff drama, and a season-shaping Monday Night Football finale. It’s the kind of schedule that rewards preparation and punishes the casual play.
| Date | Matchup | Time | Location |
|---|---|---|---|
| Thursday, December 18, 2025 | Los Angeles @ Seattle | 7:15 PM | Lumen Field, Seattle, WA |
| Saturday, December 20, 2025 | Green Bay @ Chicago | TBD | Soldier Field, Chicago, IL |
| Saturday, December 20, 2025 | Philadelphia @ Washington | TBD | Northwest Stadium, Landover, MD |
| Sunday, December 21, 2025 | Buffalo @ Cleveland | 12:00 PM | Huntington Bank Field, Cleveland, OH |
| Sunday, December 21, 2025 | Los Angeles @ Dallas | 12:00 PM | AT&T Stadium, Arlington, TX |
| Sunday, December 21, 2025 | Kansas City @ Tennessee | 12:00 PM | Nissan Stadium, Nashville, TN |
| Sunday, December 21, 2025 | New York @ New Orleans | 12:00 PM | Caesars Superdome, New Orleans, LA |
| Sunday, December 21, 2025 | Minnesota @ New York | 12:00 PM | MetLife Stadium, East Rutherford, NJ |
| Sunday, December 21, 2025 | Tampa Bay @ Carolina | 12:00 PM | Bank of America Stadium, Charlotte, NC |
| Sunday, December 21, 2025 | New England @ Baltimore | 12:00 PM | M&T Bank Stadium, Baltimore, MD |
| Sunday, December 21, 2025 | Jacksonville @ Denver | 3:05 PM | Empower Field at Mile High, Denver, CO |
| Sunday, December 21, 2025 | Atlanta @ Arizona | 3:05 PM | State Farm Stadium, Glendale, AZ |
| Sunday, December 21, 2025 | Pittsburgh @ Detroit | 3:25 PM | Ford Field, Detroit, MI |
| Sunday, December 21, 2025 | Las Vegas @ Houston | 3:25 PM | NRG Stadium, Houston, TX |
| Sunday, December 21, 2025 | Cincinnati @ Miami | 7:20 PM | Hard Rock Stadium, Miami Gardens, FL |
| Monday, December 22, 2025 | San Francisco @ Indianapolis | 7:15 PM | Lucas Oil Stadium, Indianapolis, IN |
NFL Handicapping Leaderboard
Our Top Handicappers are locked in, analyzing travel fatigue, weather impacts, motivation levels, and coaching strategies unique to this time of year. These picks aren’t just reactions—they’re designed for December wins.
Week 16 offers a full betting menu: spreads, totals, moneylines, and teaser spots with high payout potential. If you’re looking to wrap the year with a strong betting push, this is your window.
NFL Week 16 Picks
Explore our complete NFL Week 16 odds and predictions for expert insights, betting trends, and key matchup breakdowns. From playoff hopefuls to surprise upsets, we’ll help you spot the angles before the books adjust.
Bet Smarter This Holiday Week with Scores and Stats
While others are distracted by the season, you can stay focused on the edge. Week 16 rewards those who pay attention—and we’re bringing you every angle, stat, and signal you need to finish the season strong.
Stay updated all weekend long by following us on Instagram @scoresandstats, on X @scoresand_stats, and on YouTube for matchup previews, weather reports, and last-minute betting advice.
From updated NFL odds to expert-level game previews, Scores and Stats is your best resource for making smart, profitable picks during the holiday blitz of Week 16.
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