Two-thirds of the 2025 college football season is behind us. The College Football Playoff picture is still pretty blurry, but a few teams appear to be locks. No. 1 Ohio State and No. 2 Indiana appear to be headed for a date in the Big Ten championship game.

The Buckeyes play at Purdue this weekend. Indiana is at Penn State. Both OSU and the Hoosiers are double-digit favorites. Texas A&M, Alabama, and Georgia all appear headed to the playoffs, though the Bulldogs and the Aggies both have a game against Texas remaining.

Week 10 brought us some solid Sun Belt and Conference USA mid-week action, but this week marks the final push of the regular season. That means it’s time for the MAC to give us plenty of mid-week treats and new conference member Massachusetts kicks it off for us when the Minutemen travel to Akron on Tuesday night. The other Tuesday MAC matchup should be a good one between Miami and Ohio, the two teams that played for the conference title in 2024.

These final weeks of the regular season will play a huge role in determining the field for the 2025 College Football Playoffs. There are a number of key games in the Big Ten and SEC that could go a long way in determining how many playoff spots both of those conferences receive.

As we look ahead to Week 11 of the college football schedule, make sure you are checking ScoresandStats on a daily basis from now until the college football national championship game. Our NCAAF experts will continue to provide inside analysis, free picks, game predictions, and more!

College Football Week 11 Schedule

College Football Week 11 Odds

Keep an eye on the latest College Football odds from the top online betting sites and monitor how the lines change throughout the week.

It’s rare at this point in a college football season to see some of the large point spreads that we see in the non-conference portion of teams’ schedules. However, we do see a few point spreads in the high 20s this week.

Both Miami and East Carolina are 28.5-point favorites in their respective conference games against Syracuse and Charlotte. The largest spread on the board, though, belongs to No. 1 Ohio State. The Buckeyes are 29.5-point road favorites against Purdue.

The largest total on the board is in a Thursday night American Athletic Conference matchup between UTSA and South Florida. Both teams have prolific offenses which is why the game total is approaching 70. Currently, the total is 68.5 and could see more upward movement before kickoff.

Not surprisingly, the lowest total on the board is a Big Ten game involving Iowa. The Hawkeyes defense is outstanding. Iowa hosts No. 6 Oregon and the game total is currently 41.5.

Make sure you check ScoresandStats top handicappers each week of the college football season. They can help you understand how to approach some of these big point spreads and game totals.

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College Football Week 11 Predictions

Let’s take a look at the featured College Football Week 11 games and make our NCAAF picks for each game.

Tulane Green Wave @ Memphis Tigers Odds

Tulane and Memphis have played in each of the last 11 seasons. The road team has won each of the last two games in the series. The Tigers went 11-2 last season and beat the Green Wave in New Orleans in the final regular season game of the season.

The Tigers covered the spread in their first three games last season, but only covered in three of their remaining 10. Memphis had one of the best offenses in the country last season, finishing in the top 20 in both scoring (35.7 ppg, 13th) and total offense (444.5, 16th). This year, the Tigers will not have four-year starter Seth Henigan at quarterback.

Tulane’s offense finished seventh in the nation last year in scoring. The offense doesn’t put up as many points (25.9 ppg) this season with Jake Retzlaff, the BYU transfer, at quarterback. The defense has been mediocre and just gave up 48 points to UTSA last week.

Memphis is 14-4 SU in its last 18 games against Tulane. The Tigers have won 8 of the last 9 against the Green Wave at home.

Tulane Green Wave @ Memphis Tigers Predictions

Tulane relies heavily on Retzlaff and his dual-threat ability. The Memphis defense is vastly improved and actually ranks 24th in the nation in scoring defense. The Tigers give up 19.2 points per game and they are excellent at taking the ball away from opposing offenses. Memphis ranks in the top-25 in both recovered fumbles and interceptions.

That opportunistic defense has been a big factor in Memphis going 8-1 thus far in 2025. The Tigers stumbled at UAB. Other than that, the Tigers have been headed toward a date in the AAC championship game at the end of the season.

Last year, Memphis was a 13.5-point underdog on the road against Tulane. In 2023, they were 5-point home underdogs. Now, with the favorable QB matchup – Brenden Lewis vs. Retzlaff – the Tigers are 6-point home favorites. Don’t forget, this line opened at Memphis -4.5 and has moved to -6.

Bet: Memphis -230, Memphis -6 (-112), Over 55.5 (-105)

BYU Cougars @ Texas Tech Red Raiders Odds

It’s the biggest game of the day between two college football programs with a very short history. The two teams met way back in 1940 in Lubbock. The Red Raiders won that game 21-20.

The most recent meeting was two years ago in Provo. Texas Tech was a 3-point road favorite but lost the game 27-14. Now, the two teams meet as the top two teams in the Big 12. BYU is the only remaining unbeaten. The Red Raiders only loss came at Arizona State earlier this season.

BYU Cougars @ Texas Tech Red Raiders Predictions

BYU continues to pass every test. They were home underdogs to in-state rival Utah and pulled the upset, 24-21. Last week, the Cougars traveled to Iowa State as 2.5-point underdogs. Once again, BYU answered the call with a huge second half, outscoring the Cyclones 24-3 on the way to a 41-27 victory.

The Cougars are extremely efficient and well-balanced on offense. They rank 16th in the FBS in scoring, averaging 36.2 points per game. It all starts with the run and RB LJ Martin who has 789 rushing yards and five touchdowns. BYU averages 216.6 yards rushing per game.

QB Bear Bachmeier is equally efficient in the passing game, completing 63 percent of his passes for 1,693 yards and 11 touchdowns. Bachmeier has also rushed for 408 yards and nine more scores.

The Red Raiders can also light it up with QB Behren Morton leading the nation’s 14th-best passing game (293.1 ypg). The ground game is solid – 199.2 ypg – and, like BYU, Texas Tech can play some serious defense. The Red Raiders allow just 13.2 points per game. BYU allows 17, which ranks 16th in the country.

The line on this game is an interesting one. The Red Raiders are likely such big home favorites because of some injuries in the BYU secondary. Safeties Raider Damuni and Talan Prassas are questionable right now. If they don’t play, the Texas Tech offense could roll.

Still, 10.5 just seems like too big of a number for a game featuring two top-notch programs.

Bet: ML pass, BYU +10.5 (-115), Over 52.5 (-110)

Indiana Hoosiers @ Penn State Nittany Lions Odds

Penn State joined the Big Ten in 1993. The Nittany Lions have played Indiana 27 times, all as a member of the Big Ten. It’s no surprise that Penn State holds a huge advantage in this series. The Nittany Lions are 25-2 all-time versus the Hoosiers.

The most recent win was an exciting one. QB Michael Penix Jr., who now starts for the Atlanta Falcons in the NFL, ran in a two-point conversion in overtime as the Hoosiers beat Penn State 36-35 in Bloomington in 2020.

Indiana Hoosiers @ Penn State Nittany Lions  Predictions

At the beginning of the season, we said that Curt Cignetti and his Indiana Hoosiers wouldn’t sneak up on anybody this season. They haven’t. What they have proven is that they may be even better than last year’s team.

Indiana heads to Happy Valley with a 9-0 record. They have continued to dominate their opponents. The Hoosiers lead the nation in average scoring margin. They beat opponents by an average of 31 points per game.

The offense is deadly once again with QB Fernando Mendoza leading the charge. Mendoza is a leading Heisman contender having completed 72.3 percent of his passes for 2,124 yards and 25 touchdowns. 

The Hoosiers average 46.4 points per game, which is now No. 1 in the nation. The defense is equally solid, allowing just 10.8 points per game. That ranks third among all FBS defenses. Indiana has had some issues on the road. They beat Iowa 20-15 and then-No. 3 Oregon 30-20.

Penn State is not Oregon and it’s not Iowa either, a team the Nittany Lions just lost to on October 18. The Nittany Lions, of course, have gone through some serious difficulties including the firing of head coach James Franklin.

These two teams did not play last year. The year before, Penn State was a 31-point home favorite. Indiana kept it close – 33-24 – and covered. They’ll do more than that this year.

Bet: ML pass, Indiana -15.5 (-110), Over 49.5 (-110)

Texas A&M @ Missouri Tigers Odds

These two newer SEC members have only played 17 times in college football history. Texas A&M leads the series 10 to 7. The Aggies won the last two games in the series. The most recent was last year when Texas A&M won big, 41-10.

It was one of just three losses for Missouri last season. The Tigers would lose three games, all in SEC play, all to ranked opponents. Missouri won all eight games in which it was the home team. The defense was very good, ranking in the top 25th in both scoring defense (20.4, 21st) and total defense (317.5, 17th).

The Tigers defense helped them cover the spread in seven of their final eight games of the season last year. The Aggies were a top-35 scoring defense, but they actually lost four of their last five games last season. They also went 0-5 ATS in their final five games.

Texas A&M @ Missouri Tigers Predictions

Texas A&M is ranked No. 3 in the nation after starting the season 8-0. QB Marcel Reed leads an offense that ranks 11th in the nation in scoring – 37.8 points per game. The Aggies were actually the top-scoring team in SEC games last season. The prolific offense has continued in 2025.

The defense has done enough and ranks in the top-50 versus both the run and pass. The Aggies defense will face Missouri’s QB3 in Matt Zollers. Zollers finished the Vanderbilt game after starter Beau Pribula was injured. It is unlikely that Pribula returns this season after suffering a dislocated ankle.

Backup Sam Horn was hurt early in the season, leaving Zollers to start his first college game against the No. 3 team in the country. There is little depth behind him too as the rest of the quarterbacks on the roster are all walk-ons, including Drew Lock’s nephew, Tommy.

Zollers went 14-for-23 for 138 yards and a touchdown in his time against Vanderbilt. He’ll go up against another good SEC defense. This line opened at -5.5 and has moved to -7, but we think it should be even higher.

Bet: ML pass, Texas A&M -7 (-110), Under 49.5 (-110)

Florida Gators @ Kentucky Wildcats Odds

Florida head coach Billy Napier was fired after a 3-4 start. The Gators played rival Georgia tough last week in the World’s Largest Outdoor Cocktail Party. Now, they travel to Kentucky, which is fresh off a 10-3 win over Auburn, which just fired its head coach.

The Wildcats have won the last two games in the series against the Gators played at Kentucky. In fact, the Wildcats won three straight from 2021 to 2023 before the Gators won 48-20 last year in Gainesville.

Florida leads the all-time series 54-20. Kentucky has won three of the last four, but prior to that the Wildcats didn’t have much luck against the Gators. From 1987 to 2017, Kentucky had a grand total of zero wins against Florida.

Florida Gators @ Kentucky Wildcats Predictions

After last season, Florida QB DJ Lagway was an early Heisman Trophy candidate. With the Gators losing so many games early in the season, Lagway is no longer part of that discussion. He hasn’t been as sharp this season – 65% completion rate, 1,679 yards, 10 touchdowns, and nine interceptions. He also hasn’t run the ball effectively (45 carries, 36 yards).

The Gators’ saving grace has been its defense. Florida ranks in the top-35 against the run and in scoring defense (20.5 ppg). That defense helped the Gators beat Texas and Mississippi State and keep last week’s 24-20 loss to Georgia close.

Kentucky’s win last week was much-needed after losing four straight SEC games. The Wildcats are built much like the Gators. The offense ranks 103rd (22.4 ppg) in scoring (Florida ranks 108th). The Wildcats defense is solid enough to keep Kentucky in games. They just can’t put up enough points on offense.

The Gators have been underdogs to Kentucky in each of the last two seasons. That includes 2023 when Florida was a 1-point underdog in Lexington. Now, you see the Gators favored by three against a team coming off a big win and playing at home where it has beaten Florida in two straight. That is pretty telling.

Bet: Gators -166, Gators -3 (-115), Under 45.5 (-110)

LSU Tigers @ Alabama Crimson Tide Odds

Alabama rules this Deep South rivalry that has been dubbed the “First Saturday in November” as well as the “Saban Bowl” since both teams had Nick Saban as a head coach. The Crimson Tide is 57-27-5 lifetime versus LSU and Alabama has won each of the last two in the series, both by double-digit margins.

The Tide has won 12 of the last 14 games against the Tigers. LSU last won in 2022, winning 32-31 in overtime. That game was in Baton Rouge. LSU’s last win in Tuscaloosa came during the 2019 season when the Tigers went unbeaten, won the SEC title, and went on to win the CFP national championship.

LSU Tigers @ Alabama Crimson Tide Predictions

These two teams have been headed in very different directions since the beginning of the season. LSU opened up with a huge win over Clemson and won its first four games of the season.

Alabama suffered an ugly 31-17 loss to Florida State in its opener. The Tide faithful quietly wondered if Kalen DeBoer was in over his head. They are worried no more.

The Crimson Tide have won seven straight since that loss and they have picked up big wins over rivals Georgia and Tennessee as well as wins over ranked Missouri and Vanderbilt. It’s been an impressive display for DeBoer and Alabama and the Tide’s offense.

Alabama ranks No. 15 in passing offense and the Tide averages over 30 points per game. The defense has been outstanding. Alabama ranks 20th in scoring, allowing just 18.2 points per game. They are 12th against the pass (163.6 ypg) and they will face an LSU offense that has been a major disappointment this year.

That offense is one of the reasons why LSU is 5-3 and ultimately fired head coach Brian Kelly. The Tigers had a bye last week, but that won’t give them much of an advantage. Alabama also had a bye.

The last two games in the series have had a closing line of Alabama -3. The Crimson Tide won both games 42-13 last year and 42-28 in 2023. The look ahead lines earlier this season were closer to Alabama -6.5 and now we’re at 10.5.

Bet: ML pass, Alabama -10.5 (-112), Under 50.5 (-115)

Navy Midshipmen @ Notre Dame Fighting Irish Odds

It’s one of college football’s great rivalries. Notre Dame has been playing the service academies since the beginnings of the sport. It’s no surprise that Notre Dame holds an 81-13-1 advantage in the series. The Fighting Irish have won the last seven games in the series. The last Navy win was in 2016, a 28-27 Midshipmen win.

The Navy triple option and now hybrid Wing-T will give the Irish some fits, but Notre Dame is just that much better. The Irish won last year 51-14. Navy returns a ton of talent on offense, including QB Blake Horvath and all three running backs.

Navy Midshipmen @ Notre Dame Fighting Irish Predictions

Don’t forget, the Irish played for a national championship last year. They very well could again this season. Since losing the first two games of the season, the Irish have run roughshod over their competition, winning six straight.

C.J. Carr has excelled at quarterback and the offense has been outstanding. The passing game ranks 26th (274.6 ypg) and the rushing offense is 31st averaging over 187 yards per game. The backfield tandem of Jeremiyah Love and Jadarian Price is the best one-two punch in the country.

The Irish average 37.4 points per game and are a tough bunch to stop. The issue Notre Dame may have is defending Navy’s offense. The Irish struggle against the pass (120th nationally), but have a very stingy run defense (12th, 89 ypg). Notre Dame has not faced an option-heavy team like Navy and could struggle with what is the No. 1 rushing offense in the nation.

In the end, the Irish just have too much talent on both sides of the ball and they are playing extremely well. They need to continue to make statements in their victories to earn the backing of the playoff committee come selection time.

Last year as 13.5-point road favorites, Notre Dame won by 37. Two years ago at home, ND was a 20.5-point favorite and won by 29.

Bet: ML pass, Notre Dame -25.5 (-108), Under 56.5 (-115)

Best College Football Week 11 Bets

Here are our favorite College Football bets for Week 11:

• Tulane @ Memphis -6 (-112)
• BYU +10.5 (-115) @ Texas Tech
• LSU @ Alabama Under 50.5 (-115)

Memphis is ranked 22nd in the nation at 8-1 so far this season. The only blemish on the record was an upset loss at UAB. Last year, Tulane was on a tear with QB Darian Mensah. The Green Wave were favored in that game by 13.5 points at home. Now, they are on the road and find themselves as 6-point underdogs after the line opened at Memphis -4.5. That’s telling us something.

BYU has some injury concerns in its secondary, but the Cougars defense has answered the call time and again. BYU only allows 17 points per game. As a result, the Cougars are 6-2 ATS this season, including 3-1 ATS in road games. They just covered consecutive games in which they were the underdog, actually winning both outright. We don’t know if they’ll win this one, but they can keep it within 10.

Over the years, this LSU-Alabama game has featured tons of offense. The game has also seen its share of totals in the high 50s and 60s. The last time this game had a closing total less than 56.5 was in 2018. The closing total was 51.5. The game went Under (Alabama 29, LSU 0).

If you want to place all three of these Week 11 picks into an NCAAF parlay, then you would win a staggering $562 on a $100 wager. That’s nearly a 6x on your investment. If you want more parlay action, check out our best College Football parlays of the week. For the NFL bettors, we also have an NFL parlay of the week.