Week 13 of the 2025-26 NFL season is one of these most beloved weeks of the year. Unofficially dubbed “Thanksgiving Week,” NFL bettors and fans will have four days of football action to carefully choose which games to bet on.

The week opens with three Thanksgiving Day games. And, this year, all three games are exciting to watch: Packers vs. Lions, Chiefs vs. Cowboys, and Bengals vs. Ravens.

The Cincinnati vs. Baltimore game will replace the weekly Thursday Night Football game even though it doesn’t officially fall under that banner.

On Friday, the NFL will hold their third annual Black Friday game. And, we have another intriguing matchup as the Super Bowl champs Philadelphia Eagles host the NFC North leading Chicago Bears.

Sunday’s slate of games is about as exciting as a fourth day of Thanksgiving leftovers. However, there are few matchups that will definitely appeal to fans: Bills vs. Steelers, Texans vs. Colts, and the Sam Darnold bowl of Vikings vs. Seahawks.

Because this is a holiday week, all 32 NFL teams will be playing. However, Week 14 will see teams go back on bye.  

Without any further delay, let’s take a look at the NFL Week 13 odds and make our early Week 13 picks. There’s no shame in getting your Week 13 NFL bets in early as there is some value on the boards.

NFL Week 13 Schedule

NFL Week 13 Odds

As we dive into the early Week 13 NFL odds, there are several notable betting lines that jump off the page at the best sports betting sites.

Detroit is again laying fewer than a field goal at home in the Thanksgiving opener, while Kansas City is a short road favorite against a dangerous Dallas offense. The biggest favorites of the week are the Rams over Carolina and the Seahawks at home against Minnesota, both laying double digits.

Totals are more modest than some earlier slates, but Bears–Eagles and Bills–Steelers both sit in the mid-to-high 40s, while 49ers–Browns sports one of the lowest numbers of the week.

As always, make sure to monitor injuries, weather, and line movement as we move closer to kickoff, and don’t forget to check out our top player prop bets of the week for more ways to attack this card.

With that in mind, if you still need further assistance for Week 13, or any other week of NFL season, then check out the industry’s best handicapping membership for elite NFL picks. You can also enjoy a free trial by signing up today.

NFL Week 13 Predictions

Let’s take a look at the full slate of NFL Week 13 matchups and make our NFL picks for each game.

Green Bay Packers vs. Detroit Lions Odds

The Detroit Lions enter Thanksgiving with real offensive momentum after their 34–27 win over the New York Giants, powered by a dominant ground performance from Jahmyr Gibbs, who erupted for 219 rushing yards on just 15 carries with two touchdowns.

Detroit didn’t need Jared Goff to carry the load, but he still delivered an efficient 28/42 for 279 yards and two scores. Amon-Ra St. Brown commanded volume again with 9 catches for 149 yards and a touchdown, highlighting how easily Detroit can toggle between explosive runs and high-efficiency passing depending on defensive alignment. Despite surrendering 27 points, the Lions controlled the tempo, piled up 237 rushing yards, and showed that their offense remains one of the most versatile and matchup-proof units in the NFC.

Green Bay, meanwhile, is riding a quietly impressive stretch defensively, most recently holding the Minnesota Vikings to just 6 total points in a 23–6 win. The Packers didn’t produce gaudy passing numbers — Jordan Love went 14/21 for 139 yards — but they ran the ball effectively behind Emanuel Wilson, who logged 28 carries for 107 yards and 2 TDs.

That ball-control approach complemented a defensive effort that suffocated J.J. McCarthy, holding him to 87 yards passing while sacking him five times. The Packers also held Minnesota to 93 total rushing yards, showing improved gap discipline and consistent front-seven play. If Green Bay can replicate that defensive performance, they can force Detroit into longer drives instead of explosive chunk plays.

However, the matchup dynamics lean heavily toward Detroit. Minnesota’s run game is functional but not remotely comparable to Detroit’s Gibbs/Montgomery tandem, and Green Bay’s defense has been less consistent against teams with strong outside-zone looks.

Detroit’s offensive line generated huge lane-wide rushing opportunities for Gibbs against the Giants, and even though the Giants defended the run inconsistently, the burst and spacing created by Detroit’s blocking should translate against a Packers front that has struggled at times to contain speed backs. Additionally, St. Brown’s ability to win as a chain-mover and YAC threat creates leverage problems for Green Bay’s corners, who have been solid but haven’t faced a receiver of his caliber in several weeks.

The biggest challenge for the Packers will be matching Detroit’s scoring pace. Green Bay managed the Vikings largely through field position and defensive dominance, but Love averaged only 6.6 yards per attempt, and the team generated no passing touchdowns.

Against Detroit’s offense — which regularly requires opponents to push past 24–27 points to stay competitive — Green Bay will need far more from its vertical passing game. Unless Love and his receivers (Watson, Wicks, Doubs) can consistently produce chunk plays on early downs, the Packers may find themselves forced away from the run-heavy script that has carried their recent success. Detroit’s defensive front is also better than the Giants group that just surrendered 395 yards to New York’s passing attack; Green Bay will not have the same margin for error.

Green Bay Packers vs. Detroit Lions Predictions

• Spread: Lions -2.5 (–112)
Detroit’s explosive run game and offensive versatility create a difficult matchup for a Green Bay team that must stay ahead of the chains to be effective. The Lions’ balance and home-field advantage tilt this toward the favorite.

• Total: Over 48.5 (–115)
With Detroit capable of scoring quickly and Green Bay likely needing to open up the playbook, both teams should push this into the 50-point range.

• Moneyline: Lions (–142)
Detroit’s offensive ceiling, improved rushing efficiency, and superior weaponry give them a clear path to controlling the game script.

Bet: Lions ML (–142), Lions -2.5 (–112), Over 48.5 (–115)

Kansas City Chiefs vs. Dallas Cowboys Odds

Kansas City rolls into this matchup after a tight 23 to 20 win over Indianapolis where Patrick Mahomes had to carry a bigger scoring load than usual. He finished with 352 passing yards on 46 attempts and spread the ball around well, with Rashee Rice putting up 141 yards and Xavier Worthy adding 59. The Chiefs ran the ball a lot with Kareem Hunt getting 30 carries, but he averaged only 3.5 yards per rush, so yardage did not come easy.

Dallas pulled off a tougher win against Philadelphia and Dak Prescott put together one of his cleaner outings of the season. He threw for 354 yards with two touchdowns and hit big plays downfield to George Pickens and CeeDee Lamb. The Cowboys also ran for 125 yards and leaned heavily on Javonte Williams, who handled 20 carries and gave the offense steady gains.

Both teams showed firepower in their last games but they won in different ways. Kansas City needed Mahomes to push the ball vertically and take on pressure, and he was sacked four times while still finding chunk plays. Dallas created explosive plays off play action and used their run game to keep Philadelphia honest, which helped the receivers win one-on-one matchups.

This matchup sets up like a quarterback duel with both defenses giving up yardage through the air in their last outings. Mahomes has a tougher task because Dallas forced Jalen Hurts into a slow start and limited the Eagles to 21 points while generating steady pressure. Prescott should find openings again since Kansas City gave up 181 yards to Daniel Jones and struggled to win early downs.

Kansas City Chiefs vs. Dallas Cowboys Predictions

Spread: Chiefs -3.5
Kansas City has the stronger passing edge and can create more explosive plays if this becomes a high-tempo game.

Total: Over 52.5
Both teams showed they can score in bunches and neither defense looked airtight last week.

Moneyline: Chiefs
Mahomes gives Kansas City a small edge in tight games and the Cowboys are coming off an emotional win.

Bet: Chiefs -3.5 (-105), Over 52.5 (-110), Chiefs ML (-180)

Cincinnati Bengals vs. Baltimore Ravens Odds

The Bengals come into this game off a 26 to 20 loss to New England and the offense struggled to create any rhythm with Joe Flacco under center. He threw for only 183 yards on 37 attempts and took constant pressure that killed drives. The run game never found much space either, outside of Chase Brown’s 107 yards on 19 carries, and even that came mostly on early downs before the Patriots tightened up.

Cincinnati gets a major boost with Joe Burrow returning after missing months with turf toe, which immediately changes how defenses play them. Burrow’s timing and rhythm throws should help Tee Higgins and Andrei Iosivas get cleaner windows than they had with Flacco. The Bengals will still need their protection to hold up because they gave up a sack on a key third down last week and stalled in the red zone multiple times.

Baltimore’s last win came in a 23 to 10 game against the Jets where the defense controlled the pace from the start. They held New York to 78 rushing yards and forced Tyrod Taylor into a modest outing outside of a few chunk plays to Breece Hall and John Metchie. The Ravens also got steady production from Derrick Henry, who ran for 64 yards and two touchdowns, even though Baltimore only had 98 rushing yards as a team.

The Ravens did not throw much in that game and Lamar Jackson finished with only 153 yards on 23 attempts, which shows they leaned heavily on their ground approach and defense. Cincinnati should expect more of the same because the Ravens were able to grind out long drives and avoid mistakes. Burrow’s return gives the Bengals enough firepower to test Baltimore’s coverage, but the Ravens’ run game and defensive pressure still set the tempo.

Cincinnati Bengals vs. Baltimore Ravens Predictions

Spread: Bengals +7
With Burrow back, Cincinnati has a real chance to keep this inside one score and match Baltimore’s drives.

Total: Under 51.5
Baltimore leans on the run and long possessions and that can keep the number lower.

Moneyline: Ravens
Burrow gives the Bengals life, but Baltimore’s physical style at home is still the safer side.

Bet: Bengals +7 (-110) Under 51.5 (-110), Ravens ML (-360)

Chicago Bears vs. Philadelphia Eagles Odds

The Bears enter this matchup after a 31 to 28 win over Pittsburgh that showed how fast their offense can score when Caleb Williams gets rolling. He threw for 239 yards with three touchdowns and did most of his damage by spreading the ball around to DJ Moore, Rome Odunze, and Colston Loveland. Chicago also ran for 99 yards and kept the Steelers off balance with steady early-down gains from Kyle Monangai and Williams.

Philadelphia comes in off a tight 24 to 21 loss to Dallas where the offense moved the ball but stalled at key moments. Jalen Hurts threw for 289 yards and rushed for two touchdowns, and he kept drives alive with accurate throws to A.J. Brown and DeVonta Smith. The Eagles only ran for 63 yards though, and their line had trouble opening lanes for Saquon Barkley.

Both defenses showed cracks last week, and each gave up long drives that flipped momentum. Chicago surrendered 186 rushing yards to Pittsburgh and got caught out of position on edge runs. Philadelphia allowed multiple explosive plays to Dallas and gave up 354 passing yards as Prescott picked apart their coverage.

The big question for this game is whether the Bears can keep Williams clean long enough to attack Philadelphia’s secondary. The Eagles can heat up the pocket quickly, but Chicago’s quick passing game and athletic receivers can win if they avoid long-yardage downs. Philadelphia’s offense should move the ball, but they might need long drives again if Barkley can’t get past the line of scrimmage.

Chicago Bears vs. Philadelphia Eagles Predictions

Spread: Bears +7
Chicago has enough passing punch to stay inside the number if Williams avoids mistakes.

Total: Under 44.5
Both teams used long possessions last week and neither rushing attack is firing right now.

Moneyline: Eagles
Philadelphia’s offense is steadier drive to drive and should finish more red zone chances.

Bet: Bears +7 (-115), Under 44.5 (-110), Eagles ML (-325)

Houston Texans vs. Indianapolis Colts Odds

Houston comes into this matchup off a tight 23 to 19 win over Buffalo where the defense held steady even with long drives by the Bills. Houston leaned on a balanced approach and avoided mistakes as Davis Mills threw only 30 passes and the Texans ran it 26 times. Nico Collins and Christian Kirk combined for 109 yards and two touchdowns on just eight total catches. The Texans didn’t generate many explosive rushing plays outside of a 19 yard run from Woody Marks, but they did enough to stay ahead in the second half. The bigger question this week is how the offense opens up if CJ Stroud returns after missing three games with a concussion.

Indianapolis is coming off a 23 to 20 overtime loss in Kansas City where they stayed competitive but struggled to finish drives. Daniel Jones threw for 181 yards with two touchdowns on 31 attempts, but the Colts stalled multiple times inside the 30. Jonathan Taylor never found consistent running room and finished with just 58 yards on 16 carries. The Colts’ pass protection held up well overall, allowing no sacks, but their inability to generate intermediate chunk plays limited their scoring ceiling. Indianapolis had only one play longer than 26 yards all afternoon.

Houston’s defense should again play a major role. They held Josh Allen to 253 yards on 7.4 yards per attempt but sacked him eight times, which stalled drives and created long down-and-distance situations. The Texans also forced a crucial fumble by Khalil Shakir. If Stroud returns, the Texans should see more consistent spacing in the passing game, which would help Collins, Kirk, and Jayden Higgins get cleaner breaks. Indianapolis allowed 352 yards to Patrick Mahomes last week and gave up 47 and 31 yard completions. That secondary will be under pressure if Houston pushes the ball downfield.

The Colts will need to control tempo with their run game to limit Houston’s pace. Taylor and the short passing game are their best path against a Houston defense that allowed only 108 rushing yards on 26 carries last week. Indianapolis didn’t create many splash plays against Kansas City outside of a 48-yard catch by Ashton Dulin. They will lean on Michael Pittman Jr. and Josh Downs underneath, but their margin tightens if the Texans force long third downs. Houston has been strong in the red zone as well, and that could be a deciding factor since the Colts were held under 24 points for the second straight outing.

Houston Texans vs. Indianapolis Colts Predictions

Spread: Texans +4.5
Stroud’s return gives Houston a lift, and their defense has been the steadier unit. This feels like a one-score game, and the Texans’ passing edge keeps them inside the number.

Total: Under 45.5
Houston prefers controlled possessions and Indianapolis has struggled to finish drives. Both teams can run clock, and the defenses match up well against what the offenses do best.

Moneyline: Colts
If Stroud returns this becomes tighter, but Indianapolis is at home and still has the more stable run game. The Colts have an easier path to late-game scoring.

Bet: Texans +4.5 (-110), Under 45.5 (-112), Colts ML (-230)

Jacksonville Jaguars vs. Tennessee Titans Odds

Jacksonville comes into this matchup after a 27 to 24 overtime win in Arizona where Trevor Lawrence threw three touchdowns and pushed the ball downfield with confidence. The Jaguars ran for 134 yards and consistently found early-down success with Travis Etienne and Bhayshul Tuten. Their offense created explosive plays through the air and spread out the Cardinals’ coverage with a mix of tight end usage and vertical routes.

Tennessee lost 30 to 24 to Seattle and once again struggled to close out a game where the defense allowed chunk gains in the passing game. The Titans surrendered 167 receiving yards to Jaxon Smith-Njigba and also gave up two passing touchdowns to Sam Darnold, which put pressure on their own offense to keep pace. Tennessee ran for only 64 yards and had trouble generating consistent push at the line of scrimmage.

The Titans did throw for 256 yards behind Cam Ward, who mixed his targets well and got efficient production from Gunnar Helm and Chig Okonkwo. Tennessee’s receivers found some room in the short and intermediate game, but the offense still hit long-yardage downs too often to sustain drives. Their inability to slow Seattle’s passing attack also forced Ward into high-pressure spots late in the game.

Jacksonville’s defense gave up 315 passing yards to Arizona but tightened in key moments and came up with timely stops to give the offense extra possessions. The Jaguars allowed 86 rushing yards to the Cardinals and will likely prefer forcing Tennessee into another pass-heavy approach. Jacksonville’s offense appears better equipped to capitalize on Tennessee’s secondary issues, especially given how well Lawrence spread the ball in Week 11.

Jacksonville Jaguars vs. Tennessee Titans Predictions

Spread: Jaguars -6.5
Jacksonville’s offense has more consistency and should create enough separation to cover this number.

Total: Over 41.5
Both teams showed passing efficiency last week and can generate enough explosive plays to push this over.

Moneyline: Jaguars
Tennessee’s defense has not shown the ability to hold up in coverage for four quarters.

Bet: Jaguars -6.5 (-108), Over 42.5 (-105), Jaguars ML (-298)

New Orleans Saints vs. Miami Dolphins Odds

The New Orleans Saints travel to face the Miami Dolphins in what looks like another grind for an offense that has struggled to finish drives. New Orleans put up only 10 points at home in a loss to Atlanta, even though Tyler Shough threw for 243 yards on 43 attempts. The Saints ran the ball 28 times for just 79 yards and never found a consistent rhythm with Alvin Kamara or the rest of the backfield.

Miami is coming off a bye after its 16 to 13 overtime win against Washington in Madrid two weeks ago. The Dolphins leaned on their ground game in that matchup, with De’Von Achane rushing 21 times for 120 yards and a touchdown while Ollie Gordon added 45 yards and another score. Tua Tagovailoa only had to throw 20 passes, finishing with 171 yards as Miami kept things controlled.

The Saints’ passing game again flowed mostly through Chris Olave, who caught nine passes for 70 yards, but the lack of explosive plays showed up on the scoreboard. They moved the ball between the 20s yet stalled in the red zone and turned it over once through the air. Against a Miami defense that just held Washington to 13 points, New Orleans will need cleaner execution on third down and more from its rushing attack.

Miami’s offense should benefit from the extra rest, especially for Achane after a heavy workload in Madrid. If the Dolphins’ offensive line gives Tagovailoa time, he has enough options with Jaylen Waddle and Achane in the passing game to stress New Orleans at multiple levels. The Saints will likely try to slow the pace and win with time of possession, but if Miami jumps out early, New Orleans may be forced into another pass-heavy script.

New Orleans Saints vs. Miami Dolphins Predictions

Spread: Dolphins -6 (–108)
Miami’s running game and fresh legs out of the bye give them a strong chance to win by more than one score.

Total: Over 41.5 (–112)
Even if the Saints stay conservative, Miami has enough firepower to push this past the low 40s.

Moneyline: Dolphins (–265)
With extra rest and a more efficient offense, Miami should control the game at home.

Bet: Dolphins ML (–265), Dolphins -6 (–108), Over 41.5 (–112)

San Francisco 49ers vs. Cleveland Browns Odds

The San Francisco 49ers enter Week 13 firmly in the NFC playoff mix after grinding out a 20 to 9 win over the Carolina Panthers, a game where their defense carried the load despite some uneven moments from Brock Purdy. San Francisco held Carolina to just 69 rushing yards and 161 passing yards, consistently forcing Bryce Young off his spots while leaning on Christian McCaffrey’s volume to control the pace. Offensively, the 49ers had to fight through inefficient drives, but their balance and physicality allowed them to stay ahead of the sticks and eventually put the game away.

Cleveland comes into this matchup after a much-needed 24 to 10 road win over Las Vegas, a game defined by their defense and a surprisingly productive outing from Shedeur Sanders. Cleveland ran for only 64 yards as a team, but Quinshon Judkins’ two touchdowns provided the necessary spark in the red zone. Sanders completed an efficient 11 of 20 passes for 209 yards, hitting several chunk plays, including a 66-yard strike to Dylan Sampson. Still, the Browns’ offensive profile remains volatile — they produced just 27 total rush attempts at 2.4 yards per carry and continue to struggle with consistency outside of isolated explosive plays.

The biggest matchup challenge for Cleveland is San Francisco’s front. Carolina wasn’t explosive last week, but the 49ers’ defensive line still generated pressure and held the Panthers to just 9 points. Cleveland’s offensive line has battled issues all season, and the Raiders managed 10 quarterback hits on Geno Smith the week prior — pressure the Browns will have to deal with again here. If San Francisco tightens coverage and forces Sanders into longer down-and-distance scenarios, Cleveland’s offense could revert back to the inconsistent version we saw earlier in the year.

Offensively, the 49ers should again be able to lean on McCaffrey, who handled 24 carries for 89 yards and a score against Carolina while adding 53 receiving yards. With George Kittle providing Purdy a steady safety valve and Jauan Jennings working underneath, San Francisco has enough weapons to sustain drives even if Purdy isn’t overly efficient. Purdy did throw three interceptions last week, but Carolina’s pressure forced him into uncomfortable spots — something Cleveland may not be able to match. If the 49ers manage the turnover battle and continue feeding McCaffrey, they should be positioned to dictate pace.

San Francisco 49ers vs. Cleveland Browns Predictions

Spread: 49ers -6.5 (–108)
San Francisco holds clear advantages in overall talent, defensive reliability, and offensive structure. If they avoid the turnover issues that cropped up last week, their run-first approach should put them in control of the matchup.

Total: Under 37.5 (–115)
Both teams trend toward run-heavy, slower-paced scripts, and Cleveland’s best chance is to shorten the game and avoid mistakes. Red-zone drives could easily end in field goals for both sides.

Moneyline: 49ers (–268)
San Francisco’s defensive consistency and ball-control approach make them the more stable moneyline side.

Bet: 49ers ML (–268), 49ers –6.5 (–108), Under 37.5 (–115)

Los Angeles Rams vs. Carolina Panthers Odds

The Los Angeles Rams return home after a strong performance against Tampa Bay where Matthew Stafford threw for 273 yards and three touchdowns. The offense kept pressure on the Buccaneers by staying balanced and finding early success with Puka Nacua and Davante Adams. The Rams also ran the ball well enough with Kyren Williams to avoid predictable situations, which helped Stafford settle in and attack intermediate windows.

Carolina comes into this matchup off a frustrating loss to San Francisco where the offense struggled to move the ball and never found a consistent rhythm. Bryce Young threw two interceptions and finished with 169 yards on 39 attempts, and the Panthers ran for only 69 yards as a team. Their offensive line had trouble handling the 49ers’ front and created little room for Chuba Hubbard or Jaleel McLaughlin to work.

The Panthers’ defense played hard but spent too much time on the field. They allowed 89 rushing yards to Christian McCaffrey and gave up multiple long drives that drained the clock. Carolina managed only nine points and failed to build any sustained pressure despite a few strong moments early in the game. The lack of offensive support put the defense in difficult spots throughout the second half.

The Rams should be able to dictate the pace again if their passing game looks anything like it did in Week 12. Stafford has been sharp, and the supporting cast is creating separation at every level. Carolina will try to slow the game down, but the Panthers have not shown the consistency needed to trade scores with a team like Los Angeles. The mismatch in offensive firepower is clear, and the Rams defense has been more reliable in key moments.

Los Angeles Rams vs. Carolina Panthers Predictions

Spread: Rams -10.5
Los Angeles has the passing edge and enough defensive push to build a lead and maintain it.

Total: Over 44.5
The Rams can score in bunches, and this total is low enough that they can carry most of the load.

Moneyline: Rams
Los Angeles has far more ways to win and should control the flow from the start.

Bet: Rams ML (-675), Rams -10.5 (-108), Over 44.5 (-115)

Atlanta Falcons vs. New York Jets Odds

The Atlanta Falcons head north to face the New York Jets in a matchup between two offenses still trying to find steady traction. Atlanta is coming off a strong 24–10 win over the New Orleans Saints, where Kirk Cousins delivered an efficient outing and the Falcons found explosive plays through Darnell Mooney, Kyle Pitts, and Bijan Robinson. Robinson added 70 rushing yards on 14 carries, and Atlanta’s offense looked noticeably more balanced with Cousins fully back in rhythm following Michael Penix Jr.’s season-ending ACL injury.

The Jets return home after a 23–10 loss in Baltimore, showing a bit more offensive functionality behind Tyrod Taylor. Taylor threw for 222 yards and a touchdown, connected well with Breece Hall and John Metchie III, and kept the Jets competitive early. However, New York once again struggled to run the ball consistently and stalled on multiple drives inside Baltimore territory. The lack of finishing ability continues to cap their scoring ceiling.

Defensively, New York played competitively for stretches but eventually surrendered field position and time of possession. Their secondary allowed several chunk throws, and the run defense never fully controlled Baltimore’s committee approach. Atlanta will try to replicate that formula — steady run game with Robinson, layered play-action looks, and selective downfield shots to stress New York’s coverage.

The Jets’ best chance is to turn this into a slowed-down, possession-controlled game built around Hall’s versatility and Taylor’s mobility. But if the Falcons protect Cousins and avoid negative plays, their overall offensive structure gives them more reliable paths to sustained drives and scoring opportunities.

Atlanta Falcons vs. New York Jets Predictions

Spread: Falcons -2.5

Atlanta’s offense is simply more stable right now, and their personnel gives them the advantage in a low-scoring environment. Cousins should be able to do enough to push Atlanta ahead.

Total: Under 39.5

Atlanta has more ways to win and the more complete offense. If they avoid turnovers, they should be able to close out a tight, grind-heavy game.

Bet: Falcons ML (–142), Falcons –2.5 (–110), Under 39.5 (–105)

Arizona Cardinals vs. Tampa Bay Buccaneers Odds

Tampa Bay returns home after a rough performance in Los Angeles, where Matthew Stafford carved up the Buccaneers’ secondary for 273 passing yards and three touchdowns. Offensively, Tampa Bay never found rhythm — Teddy Bridgewater completed just 8 of 15 passes, and the Bucs managed only 70 total passing yards behind a struggling offensive line. Rachaad White was one of the few bright spots, picking up 38 yards on the ground at 5.4 yards per carry, but the run game could not generate consistent early-down wins.

With Baker Mayfield likely sidelined again, Bridgewater appears on track to start. Tampa Bay will need a cleaner passing script to avoid the negative game flow they faced last week. A healthier receiving group featuring Chris Godwin Jr., Emeka Egbuka, and Cade Otton should allow the Bucs to push the ball more aggressively than they did in Week 12.

Arizona enters this matchup off an overtime loss to Jacksonville where Jacoby Brissett threw for 317 yards but the Cardinals still ran for just 55 yards on 20 carries. The offensive line struggled to create push in short-yardage situations, and their inability to run the ball allowed Jacksonville’s pass rush to tee off. Still, the Cardinals generated explosive plays through Michael Wilson, Greg Dortch, and Trey McBride, giving Brissett some dynamic downfield options.

Defensively, the Cardinals surrendered 256 passing yards and three touchdowns to Trevor Lawrence but were more competitive on third downs and in the red zone. They also forced a critical fumble that kept them alive late. Arizona’s primary weakness remains run defense — they allowed 134 rushing yards to Jacksonville and have struggled to contain outside-zone looks all season.

Tampa Bay has the edge up front, but their offense has been inconsistent even when fully healthy. The Cardinals have enough explosive receiving options to challenge Tampa Bay’s coverage rules, particularly if Bridgewater is forced into clear passing situations. Arizona’s defensive vulnerability against the run could open the door for Rachaad White to carry more volume than usual, but Tampa Bay may still need Bridgewater to make tough throws on third down.

Tampa Bay Buccaneers vs. Arizona Cardinals Predictions

Spread: Buccaneers –3 (–112)
Tampa Bay has the sturdier defense and should benefit from facing a Cardinals team that has struggled to stop the run and has shown volatility in pass protection.

Total: Under 44.5 (–105)
Both offenses have been inconsistent, and Arizona’s run-game issues combined with Tampa Bay’s quarterback situation point toward a slower, lower-scoring game.

Moneyline: Buccaneers –155
Even with Bridgewater starting, Tampa Bay has the more reliable roster and path to controlling the game script.

Bet: Buccaneers ML (–155), Buccaneers –3 (–112), Under 44.5 (–105)

Minnesota Vikings vs. Seattle Seahawks Odds

The Seattle Seahawks return home after a strong performance in Tennessee, where Sam Darnold threw for 244 yards and two touchdowns while adding efficient complementary production on the ground from Kenneth Walker III and Zach Charbonnet. Seattle’s defense forced a key turnover, limited explosive plays, and kept the Titans out of rhythm for most of the afternoon. With Darnold protecting the football and Jaxon Smith-Njigba continuing his ascent, the Seahawks enter Week 13 with renewed momentum.

Minnesota comes into this matchup after a 23–6 loss at Green Bay in which their offense struggled to move the ball. J.J. McCarthy exited due to injury, and all indications point to rookie Max Brosmer drawing the start on Sunday. The Vikings produced just 93 rushing yards as a team, and their offensive line had trouble handling Green Bay’s front. Without McCarthy, Minnesota leaned on Justin Jefferson and T.J. Hockenson in short-area concepts, but drive sustainability was a major issue.

Defensively, Minnesota’s front held up reasonably well, but the unit was eventually worn down by the Packers’ run-heavy approach. Emanuel Wilson and Chris Brooks broke off multiple successful early-down carries, which allowed Jordan Love to consistently work from manageable situations. The Vikings’ pressure rate dipped in the second half, and with Seattle’s offense now finding its stride, this matchup presents another challenge for a fatigued Minnesota defense.

Seattle should again be in position to dictate offensive tempo if Darnold continues to play efficiently. This will be Darnold’s first game against Minnesota since leaving the Vikings last offseason, and he’s now operating behind a much more stable structure. His connection with Smith-Njigba looks stronger each week, and Seattle’s supporting cast is creating separation at every level. With Brosmer likely starting on the road, the offensive mismatch is clear.

Minnesota Vikings vs. Seattle Seahawks Predictions

Spread: Seahawks –10.5
Seattle’s defensive versatility and improved offensive rhythm give them multiple paths to covering this number. If the Seahawks jump out early, the Vikings’ offense—behind a rookie backup—may struggle to keep pace.

Total: Under 41.5
Minnesota is unlikely to consistently sustain long drives, and Seattle may lean more heavily on Walker and Charbonnet to protect a lead. That creates a slower game script and fewer possessions overall.

Moneyline: Seahawks
Seattle has far more ways to win, particularly at home, and their improving defensive play gives them a comfortable floor.

Bet: Seahawks ML (–600), Seahawks –10.5 (–110), Under 41.5 (–115)

Las Vegas Raiders vs. Los Angeles Chargers Odds

The Las Vegas Raiders enter Week 13 after a 24–10 loss to the Cleveland Browns, a game in which their offense struggled to sustain drives. Geno Smith threw for 285 yards but was under constant pressure, taking seven sacks and finishing with a steady but inconsistent showing. The Raiders ran for only 60 yards on 21 attempts, and while Ashton Jeanty found some efficiency on the ground, Vegas’ inability to stay ahead of the sticks led to stalled possessions throughout the afternoon.

The Los Angeles Chargers, meanwhile, return from their bye week. Two weeks ago, they were blown out by Jacksonville, falling 35–6 in a performance defined by offensive breakdowns and protection issues. Justin Herbert completed just 10 of 18 passes for 81 yards before the offense faded in the second half. The run game provided little support, totaling only 42 yards on 16 attempts. Defensively, L.A. allowed four Jaguars rushing scores and struggled to contain Jacksonville’s interior run game.

The matchup hinges on whether the Chargers can regroup after the bye and stabilize their offense. The Raiders’ passing defense showed vulnerability against Cleveland, giving up chunk gains to multiple receivers, and if the Chargers can reclaim rhythm in their short and intermediate passing game, they should be able to move the ball more effectively. The Raiders will likely try to slow the game down through Jeanty and short-area passing, but their lack of offensive consistency makes extended drives difficult.

Los Angeles’ defensive front has the clear edge in this matchup. Vegas allowed seven sacks last week, and if the Chargers create similar pressure, Geno Smith may again be forced into hurried decisions. With an extra week to prepare and a much higher offensive ceiling when functioning properly, the Chargers should be positioned to dictate the terms of this game.

Las Vegas Raiders vs. Los Angeles Chargers Predictions

Spread: Chargers –10 (–108)
Los Angeles has the superior roster, extra rest off the bye, and a major advantage in offensive firepower. If protection improves even modestly, the Chargers should build and maintain a multi-score lead.

Total: Under 41.5 (–112)
Both offenses have struggled recently, and the Raiders’ pace of play trends toward slower, lower-variance games. Coupled with L.A.’s defensive advantage, this game profiles as a lower-scoring matchup.

Moneyline: Chargers (–625)
The Chargers have far more paths to victory and should control the matchup from start to finish.

Bet: Chargers ML (–625), Chargers –10 (–108), Under 41.5 (–112)

Buffalo Bills vs. Pittsburgh Steelers Odds

Buffalo enters Week 13 after a tight road loss to Houston, a game where the Bills struggled to finish drives despite moving the ball efficiently at times. Josh Allen threw for 253 yards but also tossed two interceptions, and the Bills’ offense failed to convert several key third-down situations. The run game showed flashes behind James Cook, but Buffalo once again found itself relying on late-down heroics rather than sustained consistency. Defensively, the Bills allowed several explosives through the air and had trouble getting off the field, which ultimately swung the matchup in Houston’s favor.

Pittsburgh, meanwhile, is awaiting updates on Aaron Rodgers, who missed last week’s game with a fractured left wrist. Mason Rudolph played respectably in relief, throwing for 171 yards with one touchdown and one interception, but the offense lacked its usual downfield threat and timing. The Steelers ran the ball well behind Kenneth Gainwell, who posted 92 yards at 9.2 per carry, but Pittsburgh’s defense gave up too many big passing plays to Chicago. Still, the Steelers have shown resilience at home, and their defensive front remains capable of disrupting rhythm-based offenses.

This matchup could hinge on whether Rodgers is cleared. With him, Pittsburgh’s ceiling rises meaningfully—particularly against a Bills secondary that has looked vulnerable in recent weeks. Without him, the Steelers may need to lean on their run game and rely on field position to keep things close. For Buffalo, protecting the ball and avoiding short fields will be crucial given Pittsburgh’s opportunistic defense. The Bills have the more stable offensive structure, but recent inconsistency has prevented them from pulling away in games they’ve controlled statistically.

Buffalo Bills vs. Pittsburgh Steelers Predictions

Spread: Steelers +3.5
This number reflects the uncertainty around Rodgers, but Pittsburgh has been competitive at home and should be able to keep this within one score regardless of QB. Their run game matches up reasonably well with Buffalo’s front.

Total: Under 47.5
Both teams have trended toward lower-scoring outcomes, and much depends on Pittsburgh’s quarterback situation. Even with Rodgers, Buffalo’s defense typically tightens in the red zone, and Pittsburgh prefers controlled, methodical possessions.

Moneyline: Bills
Buffalo still offers the higher overall offensive ceiling and has fewer structural issues on both sides of the ball. If they protect the football, they should be able to edge out a close one.

Bet: Bills ML (–198), Steelers +3.5 (–105), Under 47.5 (–108)

Denver Broncos vs. Washington Commanders Odds

The Denver Broncos return from their bye in good shape after a gritty 22–19 home win over the Kansas City Chiefs. Denver’s defense bent but didn’t break in that matchup, holding Kansas City to just one offensive touchdown while forcing multiple long-field situations and keeping the Chiefs’ run game in check. Offensively, Bo Nix threw for 295 yards, leaned on Troy Franklin and Courtland Sutton on the perimeter, and got enough balance from RJ Harvey and Jaleel McLaughlin on the ground to keep the chains moving.

Washington is also coming off a bye but has more questions to sort out. The Commanders fell 16–13 in overtime to the Miami Dolphins in Madrid, with Marcus Mariota playing efficiently but taking three sacks and finishing with one touchdown and one interception. Washington ran the ball 33 times in that game and still couldn’t get much going downfield, relying heavily on Deebo Samuel and Zach Ertz while struggling to generate explosives against Miami’s defense.

This matchup sets up as a difficult spot for the Commanders’ offense. Denver’s front just spent four quarters dealing with Kansas City and now gets a Washington line that allowed steady pressure from Miami and hasn’t consistently protected Mariota. If the Broncos can keep the Commanders behind the sticks and force obvious passing downs, their secondary should be able to sit on underneath routes to Samuel, Ertz, and Chris Moore.

On the other side, Denver’s offense has a clear advantage in weapons and continuity. Nix is coming off a near-300-yard outing with efficient distribution to Franklin, Sutton, Evan Engram, and a deep rotation of backs. Washington’s defense just allowed 169 rushing yards and 6.8 yards per pass attempt to the Dolphins, and now has to tackle in altitude against a Broncos team that’s comfortable leaning on the run and taking timely shots. Coming off the bye with home-field advantage, Denver has multiple paths to building and protecting a lead.

Denver Broncos vs. Washington Commanders Predictions

Spread: Broncos -6.5 (–115) — With extra rest, the more complete roster, and a passing game that just carved up the Chiefs, Denver is positioned to control the script.

Total: Under 43.5 (–110) — Both teams lean run-heavy when they can, and Washington is likely to play conservatively on the road after scoring only 13 points against Miami.

Moneyline: Broncos -310 — With the quarterback edge, stronger supporting cast, and home-field advantage off a bye, Denver is the safer side to anchor moneyline parlays.

Bet: Broncos ML (-310), Broncos -6.5 (–115), Under 43.5 (–110)

New York Giants vs. New England Patriots Odds

New England enters Week 13 after a narrow road win in Cincinnati, where the Patriots’ offense showed enough balance behind Drake Maye’s 294 passing yards to escape with a six-point victory. The run game wasn’t overly efficient, but New England hit several timely explosives in the passing game, and the defense created just enough disruption to limit Cincinnati late. Still, the Patriots continue to struggle with consistency, often alternating strong drives with multi-series stalls.

The Giants, meanwhile, are awaiting updates on Jaxson Dart, who missed last week’s game and remains questionable. Jameis Winston performed admirably in relief, throwing for 366 yards, two touchdowns, and an interception, and nearly led New York to an upset win in Detroit before falling in overtime. Offensively, the Giants unlocked far more explosive plays than usual — Wan’Dale Robinson (156 yards) and Tyrone Tracy (68 yards) both created chunk gains — but protection issues and late-down inefficiency continue to limit ceiling outcomes. Defensively, New York gave up 237 rushing yards to the Lions, an issue that could resurface here.

This matchup could hinge on the Giants’ quarterback situation. If Dart returns, New York gets a more controlled, mobility-based presence against a New England defense that’s been quietly improving. If Winston starts again, the Giants retain higher volatility on both ends — capable of hitting explosives but just as capable of turnovers. For New England, protecting Maye and avoiding short-field giveaways will be essential against a Giants defense that has played more aggressively in recent weeks.

Ultimately, New England boasts the more stable overall profile, but New York’s improved offense last week — combined with the possibility of Dart returning — makes a double-digit separation less certain than the odds imply.

New England Patriots vs. New York Giants Predictions

Spread: Giants +7.5
This number reflects the quarterback uncertainty for the Giants while still offering value. New York moved the ball surprisingly well in Detroit, created big gains in the passing game, and should be able to keep this within one score at home.

Total: Under 46.5
Both teams have trended toward lower-scoring outcomes, and New England continues to play methodical, controlled football. The Patriots’ defense typically tightens in the red zone, and New York could slow down if Dart is limited or ruled out.

Moneyline: Patriots
New England has the more consistent structural baseline and fewer defensive liabilities. If they protect the football, they should be able to edge out a close one.

Bet: Giants +7.5 (–115), Under 46.5 (–110), Patriots ML (–425)

NFL Week 13 Best Bets

CHere are our favorite NFL bets for Week 13:

• Seattle Seahawks -10.5 vs. Minnesota Vikings (–110)
• Los Angeles Chargers -10 vs. Las Vegas Raiders (–108)
• Denver Broncos -6.5 vs. Washington Commanders (–115)

Seattle gets a Vikings team likely starting rookie Max Brosmer, and the Seahawks’ defensive front should be able to compress the pocket the way Green Bay did last week. With Darnold stabilizing the Seahawks’ offense and JSN emerging as a true breakout threat, Seattle is well-positioned to control the game and cover a big number at home.

The Chargers come off a bye and should look sharper offensively after being shut down in Jacksonville before the break. With the Raiders struggling to keep pace on the road and still dealing with inconsistency from Geno Smith, Los Angeles is the more stable side and carries enough offensive firepower to extend margin.

Denver, meanwhile, has the defensive structure to frustrate a Washington team that relies almost entirely on its run game and short passing. If the Broncos continue to get efficient play from Bo Nix and avoid turnovers, their defense should create separation and push Denver toward another home cover after a strong start to the season.

If you roll these three favorites into an NFL parlay in the approximate range of –110, –108, and –115, the combined odds fall in the +500 to +550 area. A $100 wager would return roughly $600–$650 total. As always, shop for the best numbers across your sportsbook accounts and consider pairing these sides with your favorite college football parlays for added