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NFL Predictions Today and Picks Against the Spread · Sunday 18 October

Chargers vs Chiefs Best Pick, Prediction and Odds

Chargers 0-4 and Chiefs 4-0. Here is where this game stands.

The game

The Chargers visit the Chiefs on Sunday 18 October at 4:25 PM ET.

Last season finished with the Chiefs at 6-11 and the Chargers at 11-6. They last met in Week 15 of last season, when the Chargers won 16-13 in Kansas City.

This season so far

In Week 1 the Chargers lost to the Cardinals 14-26. In Week 2 the Chargers lost to the Raiders 14-26. In Week 3 the Chargers lost to the Bills 16-24 on the road. In Week 4 the Chargers lost to the Seahawks 23-30 on the road. In Week 1 the Chiefs beat the Broncos 31-10. In Week 2 the Chiefs beat the Colts 33-30. In Week 3 the Chiefs beat the Dolphins 24-10 on the road. In Week 4 the Chiefs beat the Raiders 30-27 on the road.

The early line

The early line has the Chiefs at -2.5, the median of 3 books. The total is 46.5 across 3 books.

These are look-ahead prices, read 13 Sep 17:10 UTC, and only 3 books were quoting the spread. With the bookmaker margin removed, the moneyline makes the Chiefs 57.0% to win. Expect them to move once the weeks in between are played.


Los Angeles Chargers at Kansas City Chiefs, Sunday 18 October at 4:25 PM ET. Prices: US sportsbooks via Nucleus, read 13 Sep 17:10 UTC. 2025 results: Nucleus, checked game by game against ESPN. Every Week 6 game: NFL Week 6 odds and predictions.