Week 10 of the 2025 college football season is here and we are getting into the meat of the schedule. Week 9 saw some statement wins and a big loss that left another Power 4 head coach out of a job.

No. 2 Indiana pounded UCLA 56-6 while No. 3 Texas A&M pulled away from LSU winning 49-25 and sending Brian Kelly to the unemployment line. The Tigers brass decided to part ways with Kelly after LSU’s third loss of the season, with all three coming in the last four games.

Two other top ten teams – No. 8 Ole Miss and No. 10 Vanderbilt – won their games against ranked opponents (No. 13 Oklahoma and No. 15 Missouri, respectively). The only upset of the week came when unranked Houston (7-1) beat No. 24 Arizona State 24-16. The Sun Devils had a number of injuries, but the Cougars did play well and held a 24-0 lead in the fourth quarter.

This week, we get three more matchups of ranked opponents. They are the top three games of the week:

• No. 9 Vanderbilt @ No. 20 Texas
• No. 18 Oklahoma @ No. 14 Tennessee
• No. 17 Cincinnati @ No. 24 Utah

There is still plenty of college football remaining to be played. The College Football Playoff race is starting to really heat up at this point in the season. Make sure you stay on top of the CFP by checking out the College Football Championship odds and our experts’ predictions for this year’s CFP championship.

The new week should help start to clear up the path to the College Football Playoff. Remember, 12 teams are selected by the CFP committee. The five highest-ranked conference champions receive automatic bids. The four highest-ranked teams, regardless of their conference championship status, will receive a first-round bye in the playoff.

College Football Week 10 Schedule 

College Football Week 10 Odds 

Keep an eye on the latest College Football odds from the top online betting sites and monitor how the lines change throughout the week.

For the first time since 2013, Penn State is an underdog of more than 20 points. The Nittany Lions head to Columbus as 20.5-point dogs this Saturday. Prior to the season, this was viewed as one of the top matchups of the season. That changed quickly after PSU lost four straight games.

That game is not the largest point spread on the board though. That honor belongs to Oklahoma State-Kansas where the Jayhawks are 24.5-point home favorites. The Cowboys have lost seven straight games since beating FCS UT-Martin in the season opener. Oklahoma State got the ball rolling on head coach firings when Mike Gundy was let go after a loss to Tulsa. Penn State, of course, fired James Franklin after the team’s third straight loss against Northwestern.

One of the largest totals on the board is in the Navy-North Texas game, which could be a preview of the American Athletic Conference championship game. Navy ranks 16th in the FBS in scoring, averaging 37.3 points per game. Their opponent, the Mean Green, lead the nation in scoring, averaging 46.1 points per game.

The biggest total on the board, however, is 67.5 in the Mississippi State-Arkansas game. Both teams struggle on defense and both run pass-happy offenses that can light up the scoreboard. On the other end, the Central Michigan-Western Michigan game in the MAC features the lowest total – 40.5.

I’ll walk you through each game and hand out my favorite week 10 college football picks, but I encourage you to also look to the top sports betting handicappers for a little extra help.

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College Football Week 10 Predictions

Let’s take a look at the featured College Football week 10 games and make our NCAAF Picks for each game. 

Vanderbilt Commodores vs. Texas Longhorns Odds 

First up we get a battle within the SEC, as the Vanderbilt Commodores travel down south to take on the Texas Longhorns. These two sides have only met 13 times previously, with Vandy owning an 8-4-1- series advantage.

Now ranked No. 9 in the country, the Vanderbilt Commodores continue to defy the odds. No one really thought they’d beat LSU. Those same people likely thought there is no way they can come back and beat Missouri, right?

The Commodores continue to silence the critics and they’ll have the opportunity to do it again on Saturday. This time, Vanderbilt is on the road at Texas (6-2) as a 1.5-point underdog. The two schools have only played each other 13 times.

It’s almost hard to believe, but it is true. Vanderbilt leads the all-time series with Texas, 8-4-1. All eight of those wins came between 1899 and 1928. The two teams played for the first time since 1928 last season in Nashville. Texas pulled out a 27-24 victory.

Vanderbilt Commodores vs. Texas Longhorns Predictions

The big news heading into this one is the status of Texas QB Arch Manning. He was in concussion protocol early in the week and his status is questionable. Even if he does play, this Vanderbilt team is for real.

The defense is outstanding. The Commodores held Missouri to 10 points. They rank in the top 20 against the run and they only allow 18.7 points per game. That ranks No. 24 in the country. The Longhorns offense has been nothing special and without Manning it’s tough to see how they would keep up with Vandy.

Last year, the Longhorns were 17-point favorites on the road. Now, they are 1.5-point favorites at home. That’s very telling. Vandy controls the football, they are excellent on third down and they score when in the red zone. Vandy is the better team here and has proven it can win on the road in the SEC.

Bet: Vanderbilt +100, Vanderbilt +1.5 (-112), Over 45.5 (-105)

Penn State Nittany Lions @ Ohio State Buckeyes Odds

As mentioned, at the beginning of the season all eyes were on this meeting which was projected to be a No. 1 versus No. 2 matchup. Fast forward to Week 10 and this is just another game. Penn State has lost four straight and James Franklin is no longer the head coach.

One of the reasons why Franklin is gone is because he couldn’t beat top 10 teams like Ohio State. The Buckeyes have played Penn State every year since 1993 when the Nittany Lions joined the Big Ten. PSU has won just eight times.

Since 2012, Penn State has exactly one win over the Buckeyes. It came in 2016 at Beaver Stadium where Penn State entered the game as a 19.5-point underdog. The game featured the “Block Six” where PSU blocked an Ohio State field goal attempt with just over four minutes left in the game. The field goal was returned for a touchdown and Penn State won 24-21.

Ohio State leads the all-time series 25-14.

Penn State Nittany Lions @ Ohio State Buckeyes Predictions

The Nittany Lions have lost four straight. They lost starting QB Drew Allar for the season and backup Ethan Grunkmeyer threw for just 92 yards in his first start against Iowa. The offense will rely on RBs Kaytron Allen and Nick Singleton.

The problem for Penn State is that Ohio State has the best defense in the country. They are No. 1 in the nation in yards per play (3.81) and No. 1 in scoring defense, allowing opponents just 5.9 points per game. They rank in the top 10 versus the run and the pass and Penn State’s offense isn’t particularly dynamic.

Ohio State has won the last eight in a row against Penn State. The Buckeyes won those games by an average margin of about eight points. Penn State may be able to hang around early, but not for a full game against the best team in the nation.

The Buckeyes will do the majority of the scoring here. Getting Over the total isn’t likely, especially after totals closer to 50 the last two seasons.

Bet: ML pass, Ohio State -20.5 (-115), Under 43.5 (-105)

Miami Hurricanes @ SMU Mustangs Odds

These two teams have only ever played each other once. That was back in 1965. The Mustangs won 7-3.

With the two teams now both playing in the ACC, expect the Hurricanes and Mustangs to meet more frequently. Both teams were looking at a possible ACC championship game berth, but SMU lost for the third time this season last week. Miami’s loss to Louisville could damage its hopes for an ACC championship.

Miami Hurricanes @ SMU Mustangs Predictions

The hopes were high in Dallas this offseason as the Mustangs played for an ACC championship last year, its first in the conference. Head coach Rhett Lashlee brought back a ton of talent and replaced what was lost via the transfer portal.

SMU also made the College Football Playoff last year and the early losses to Baylor and TCU, as well as last week’s loss, have killed any hopes of another trip this season. The Mustangs are at home where they are 17-2 SU in their last 19.

The Hurricanes still have all of their goals in place. They can still get to the ACC title game, though they will need some help. With just one loss, they are still in line for a CFP berth as well.

The Canes have one of the best defenses in the country. They rank eighth in scoring (14.1 ppg) and 10th against the run (87.3 ypg). SMU really struggled against Wake Forest last week. The Mustangs only ran for 75 yards and only totaled 246.

Shutting down Carson Beck and the ‘Canes offense will prove difficult too. Miami averages 34 points per game and the Hurricanes are hungry after the loss to Louisville. They rebounded last week with 42 points against Stanford.

It’s a must-win for SMU, but Miami just has too much talent. The Hurricanes covered last week as a 28.5-point favorite. They can cover the 10.5 on the road here.

Bet: ML pass, Miami -10.5 (-115), Over 50.5 (-115)

Arizona State Sun Devils @ Iowa State Cyclones Odds

These two programs don’t have a lot of history. In fact, they don’t have much recent history as they last met in 2004. Arizona State won that game 44-7 in Tempe.

The two teams have only played three times. The home team won the two regular season meetings. Arizona State scored a 17-7 victory over the Cyclones in the 1997 Sun Bowl in El Paso, Texas.

Arizona State Sun Devils @ Iowa State Cyclones Predictions

The Sun Devils quest for back-to-back Big 12 titles hit a snag last week. ASU has been banged up and it looks like QB Sam Leavitt will not play again this week. Leavitt started last week but did not finish the game. He is currently listed as out for Saturday.

If he can’t play, then it’s up to Jeff Sims who led a late scoring drive in last week’s loss to Houston. At 5-3 and 3-2 in the conference, Arizona State’s conference title and playoff hopes are just about gone. Another loss definitely takes both off the table.

Iowa State was rolling along at 5-0. Then the last three games happened. The Cyclones lost at Cincinnati, then dropped one to Colorado before losing at home last week to BYU. Iowa State led that game 24-10 late in the second quarter but was outscored 31-3 the rest of the way.

The Cyclones still have Rocco Becht at quarterback and Carson Hansen and Abu Sama provide a solid one-two punch in the running game. It’s hard to win at Jack Trice Stadium. ASU is just 1-2 SU in its three true road games this season. It’s also hard seeing Iowa State lose for a fourth straight time and two straight at home.

Bet: Iowa State -218, Iowa State -5.5 (-112), Over 50.5 (-110)

Notre Dame Fighting Irish @ Boston College Eagles Odds

It’s the classic Catholics versus Jesuits matchup with Notre Dame traveling to Chestnut Hill, Mass., to take on Boston College on Saturday. The two teams have played each other 26 times overall. Notre Dame holds a 17-9 advantage in the series.

The Fighting Irish have won the last nine straight meetings. Notre Dame has won the last four by double digits, including the last meeting in 2022 in South Bend. The Irish won that one 44-0.

Notre Dame Fighting Irish @ Boston College Eagles Predictions

This one is simply a matter of whether or not the Irish cover. Notre Dame had a bye week last week to prepare for this trip and they will be facing one of the worst defenses in all of college football.

Boston College ranks 126th in the nation in points allowed, giving up 34.4 points per game. You can’t win many games giving up that many points. That’s why the Eagles are 1-7 this season. BC ranks 112th against the pass and 99th against the run.

Notre Dame averages 39.1 points per game, 10th-best in the country. The duo of Jeremiyah Love and Jadarian Price in the backfield is one of the best – if not the best – in the nation. Love has nine rushing touchdowns. Price has eight.

QB C.J. Carr has done enough in his first season as a starter. He completes 65.8 percent of his throws for 1,758 yards and 14 touchdowns. He’s one of the reasons why Notre Dame has ripped off five straight wins since losing their first two games of the season. The Irish will be too much for BC.

Bet: ML pass, Notre Dame -28.5 (-108), Over 56.5 (-110)

Georgia Bulldogs @ Florida Gators Odds

The largest outdoor cocktail party takes place in Jacksonville on Saturday. It’s Georgia and Florida, two programs headed in opposite directions. Kirby Smart is firmly entrenched as the Bulldogs head coach. Florida just fired Billy Napier after three-and-a-half seasons of mediocrity.

The rivalry began in 1904 and Georgia now leads the series 57-44-2. For the last four seasons, it’s been all Georgia. The Bulldogs have won four straight with all of the wins by at least 14 points.

Georgia Bulldogs @ Florida Gators Predictions

In each of the last four games in this series, Georgia has been a double-digit favorite. This year, the Bulldogs are not. They are a 7.5-point chalk. That says something right there.

The Bulldogs are still in the running for the SEC title and College Football Playoff. Their only loss, of course, the 24-21 defeat at the hands of Alabama. They had a big win over Ole Miss in their last game on Oct. 18. The Bulldogs come into this game well rested.

Florida is just 2-4 SU and 1-5 ATS in its last six games. They also had last week off. Teams that fire their head coach typically see their team come out and play harder in that next game. Whether that helps the Gators in or not remains to be seen.

It’s hard to see Florida having enough success against Georgia, but it is a rivalry game. Teams rise up in situations like these and the Gators really have nothing to lose. With the spread just over the key number of seven, we’ll back the Gators for the cover in a game that should see plenty of points.

Bet: ML pass, Florida +7.5 (-115), Over 50.5 (-110)

Oklahoma Sooners @ Tennessee Volunteers Odds

Tennessee welcomed the Sooners to the SEC last year with a shocking upset in Norman. Can Oklahoma return the favor? The two teams have only ever played each other five times. They played in the 1939 and 1968 Orange Bowl games then played a home-and-home series in 2014 and 2015.

Oklahoma won both of those games and holds a 3-2 advantage in the series. Last year, Tennessee went on the road to pull off a huge upset, beating the Sooners 25-15.

Oklahoma Sooners @ Tennessee Volunteers Predictions

Oklahoma comes off a tough loss to Ole Miss at home last week. One of the nation’s best defenses gave up 34 points to the Rebels last week. The Sooners gave up 315 yards passing and allowed Ole Miss to do just about anything it wanted.

The Sooners offense is not all that dynamic. They did score 26 points last week, but they have issues running the ball (130.1 ypg, 100th in the nation). QB John Mateer is an outstanding dynamic dual-threat quarterback, but he is not 100 percent. That will slow down the Sooners offense.

Tennessee is one of the best offenses in the country. The Veer-n-Shoot of head coach Josh Heupel puts up points by the bunches. Tennessee ranks No. 2 in the nation in scoring, averaging 45.6 points per game.

Joey Aguilar and the Vols passing game ranks No. 3 in the nation averaging over 321 yards per game. The Vols also run for 189 yards a game. They are explosive and hard to stop. On the other end, the defense has some issues. Tennessee allows 30.9 points per game. That’s 114th in the nation.

The Over has cashed in 10 of Tennessee’s last 12 games.

Bet: ML pass, Tennessee -3.5 (+102), Over 56.5 (-110)

Cincinnati Bearcats @ Utah Utes Odds

These two Big 12 teams have never played before. That makes sense since Cincinnati has been in East Coast or midwest conferences while Utah spent most of its time out west.

This will be the first meeting between the schools and should be a good one since both teams are ranked in the AP Top 25.

Cincinnati Bearcats @ Utah Utes Predictions

The Bearcats are outstanding on offense led by QB Brendan Sorsby. Cincy averages 38.2 points per game, which ranks 13th in the nation. That offense goes up against one of the best defenses in college football. Utah allows an average of 14.2 points per game. That ranks ninth-best in the nation.

On the other side, Utah is just as prolific on offense, scoring 38.8 points per game, 11th-best in the FBS. Cincy’s defense ranks in the top 20 in scoring allowing just 19 points per game (28th).

Utah just came off a win over Colorado. They used backup quarterback Byrd Ficklin and the offense didn’t miss a beat. Devin Dampier is listed as questionable and whether or not he plays, the Utes are tough to beat at home. Still, laying 8.5 points seems like a big number against a team that has won seven straight.

Bet: ML pass, Cincinnati -8.5 (-110), Under 55.5 (-105)

Best College Football Week 10 Bets

There are a plenty of worthwhile week 10 college football picks to wager on, but the following are my best bets for the week:

• Vanderbilt (+1.5) @ Texas (-112)
• Oklahoma @ Tennessee -3.5 (+102)
• Notre Dame @ Boston College Over 57.5 (-110)

Vanderbilt just continues to win. Clark Lea has done an outstanding job of getting the Commodores to play like an elite SEC program. It shows. They were huge underdogs at home to Texas last year. Now, they are catching 1.5 points. Texas may not have starting QB Arch Manning.

Oklahoma is reeling after a home loss to Ole Miss. Tennessee is tough to beat at home. The Sooners had trouble with the Ole Miss offense last week. They’ll have even more problems with Joey Aguilar and Tennessee.

Notre Dame’s offense scores nearly 40 points per game. Boston College can actually put up some points and their defense is awful. They give up 34.4 points per game and the Over has cashed in 11 of their last 15 games. The Over has also hit in six of the last nine for Notre Dame.

If you want to place all three of these Week 10 picks into an NCAAF parlay, then you would win a staggering $630 on a $100 wager. That’s a 6x on your investment. If you want more parlay action, check out our best College Football parlays of the week. For the NFL bettors, we also have an NFL parlay of the week.